Heparin News and Research

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Heparin, a highly-sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines. Pharmaceutical grade heparin is derived from mucosal tissues of slaughtered meat animals such as porcine (pig) intestine or bovine (cow) lung.

Canyon Pharmaceuticals announces the availability of Iprivask inhibitor for prevention of DVT

Canyon PharmaceuticalsTM (www.canyonpharma.com) today announced the availability of Iprivask (desirudin for injection), the first direct thrombin inhibitor (DTI) approved in the United States by the Food and Drug Administration for the prevention of deep vein thrombosis (DVT), which may lead to pulmonary embolism in patients undergoing elective hip replacement surgery.

2 Mar 2010

sanofi-aventis reports 2009 fourth-quarter and full-year net earnings

Commenting on the Group's 2009 performance, sanofi-aventis Chief Executive Officer Christopher A. Viehbacher said, "2009 was the first year of implementation of our new strategy. Major steps have already been achieved in strengthening our growth platforms and reinforcing our R&D pipeline while delivering a double-digit EPS(1) growth".

10 Feb 2010

People living with IBD are at high risk of blood clots

People living with Inflammatory Bowel Disease (IBD) are known to be at high risk of blood clots when admitted to hospital during a flare-up of their disease but now new research by scientists at The University of Nottingham has shown that those who are not admitted to hospital during flare-ups are also at risk.

10 Feb 2010

PolyMedix provides overview of its 2010 clinical milestones

PolyMedix, Inc. (www.polymedix.com), an emerging biotechnology company focused on developing new therapeutic drugs to treat infectious diseases and acute cardiovascular disorders, provided an overview of its 2010 clinical milestones in a presentation by President & C.E.O., Nicholas Landekic at the 2010 BIO CEO & Investor Conference.

10 Feb 2010

Excelsior Medical receives Canadian marketing license for new, pre-filled catheter lock syringe

Excelsior Medical Corporation, one of the leading manufacturers of pre-filled catheter flush syringes, today announced that it has received a Medical Device License from Health Canada for its new, pre-filled catheter lock syringe to be sold in the Canadian marketplace.

10 Feb 2010

Preliminary study results of ExThera Medical's Seraph extracorporeal affinity therapy published

ExThera Medical announced today that the results of a preliminary study (“Cytokines in blood from septic patients interact with surface immobilized heparin”) of its proprietary medical device, Seraph™ extracorporeal affinity therapy, have been published in the current issue of the Journal of the American Society for Artificial Organs (Jan.-Feb. 2010).

9 Feb 2010

Daiichi Sankyo initiates Phase III trial of edoxaban in reducing recurrent VTE complications

Daiichi Sankyo Company, Limited, announced today that it has initiated a new large-scale pivotal Phase III trial for edoxaban, its investigational oral Factor Xa inhibitor. This new study, called HOKUSAI (pronounced hoe·koo·sigh) VTE, is evaluating the safety and efficacy of edoxaban in reducing recurrent venous thromboembolic (VTE) complications in patients with deep vein thrombosis (DVT) and/or pulmonary embolism (PE).

3 Feb 2010

FMCNA ships dialysis machines and supplies for Haiti relief efforts

Fresenius Medical Care North America (FMCNA), the world's largest integrated provider of products and services for individuals undergoing dialysis because of chronic kidney failure, is donating and delivering dialysis supplies to Haitians, at a time when relief supplies continue to be slow to reach those in need following a devastating earthquake and aftershock.

30 Jan 2010

Excelsior Medical donates medical supplies to support Haiti earthquake relief effort

Excelsior Medical Corporation, one of the leading manufacturers of pre-filled catheter flush syringes, today announced that it is donating medical supplies to support the Haiti earthquake relief effort.

28 Jan 2010

New report illustrates why cardiovascular disease is under-recognized and under-treated in women

Today, the Society for Cardiovascular Angiography and Interventions (SCAI) launched "WINHeart -- Score a WIN for Women," an initiative that raises awareness surrounding gender-based disparities in the diagnosis, treatment and survival of women with cardiovascular disease (CVD).

28 Jan 2010

GIVI scientists discover anti-HIV molecule that enhances infection, reduces transmission

Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have discovered a new agent that might inhibit the infectivity of HIV. The agent, surfen, impairs the action of a factor in semen that greatly enhances the viral infection.

5 Jan 2010

Gore introduces PROPATEN Vascular Grafts with Integrated Rings

W. L. Gore & Associates (Gore) today announced it will expand its line of GORE PROPATEN® Vascular Grafts to include configurations with a unique, all ePTFE radial support that is concealed within the ultra-smooth graft wall and resists kinking and compression. The GORE PROPATEN Vascular Graft with Integrated Rings was introduced at the 2009 AIMsymposiumTM / VEITHsymposiumTM in November in New York City.

21 Dec 2009

PolyMedix completes first two segments of its PMX-30063 antibiotic drug candidate Phase 1B study

PolyMedix, Inc., an emerging biotechnology company developing acute care products for infectious diseases and acute cardiovascular disorders, has successfully completed the first two segments of a Phase 1B clinical safety study with its novel antibiotic drug candidate PMX-30063.

18 Dec 2009

New guidelines on the management of antithrombotic agents for endoscopic procedures published

According to a new guideline from the American Society for Gastrointestinal Endoscopy (ASGE) regarding the management of antithrombotic agents for endoscopy, aspirin and/or NSAIDs may be continued for all elective endoscopic procedures.

9 Dec 2009

Generic erosion of premium-priced branded agents to offset sales of new agents

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that generic erosion of premium-priced branded agents will offset sales of new agents and will cause the acute coronary syndrome market for drugs in the hospital setting to decrease from $800 million in 2008 to $729 million in 2018 in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan.

8 Dec 2009

PolyMedix to present data on its heptagonist compounds

PolyMedix, Inc. (http://polymedix.com), an emerging biotechnology company developing acute care therapeutic drug products for infectious diseases and cardiovascular disorders, announced that data will be presented on its heptagonist compounds at the annual meeting of the American Society of Hematology in New Orleans, Louisiana.

8 Dec 2009

Dabigatran etexilate prevents recurrent VTE with less bleeding than warfarin

Boehringer Ingelheim today announced very positive results from their landmark RE-COVER™ study – the most advanced trial programme assessing a novel oral anticoagulant in development for acute venous thromboemolism (VTE) treatment – presented at the American Society of Hematology Annual Meeting1 and published in the New England Journal of Medicine online.

7 Dec 2009

Anticoagulants used to prevent clots in placental blood vessels ineffective, reveals research

Blood clotting, or coagulation, is an important process that prevents excessive bleeding when a blood vessel is injured. Sometimes, however, clots form on the inside of vessels without an obvious injury or do not dissolve naturally, a potentially life-threatening situation requiring treatment.

7 Dec 2009

New discoveries to treat life-threatening blood disorder presented at ASH annual meeting

A genetic variation that may indicate a patient's risk of developing a potentially life-threatening blood disorder if exposed to certain pharmaceutical therapies or chemicals is one of several medical discoveries scientists at cancer diagnostics leader Quest Diagnostics will present during the 51st American Society of Hematology (ASH) Annual Meeting and Exposition, December 5-8, 2009, in New Orleans, LA.

4 Dec 2009

ISIS-FXIRx and ISIS-SMNRx included in Isis Pharmaceuticals' development pipeline

Isis Pharmaceuticals, Inc. announced today that it has added two new drugs to its development pipeline, ISIS-FXIRx and ISIS-SMNRx.

4 Dec 2009

Heparin News and Research

Further Reading

Canyon Pharmaceuticals announces the availability of Iprivask inhibitor for prevention of DVT

sanofi-aventis reports 2009 fourth-quarter and full-year net earnings

People living with IBD are at high risk of blood clots

PolyMedix provides overview of its 2010 clinical milestones

Excelsior Medical receives Canadian marketing license for new, pre-filled catheter lock syringe

Preliminary study results of ExThera Medical's Seraph extracorporeal affinity therapy published

Daiichi Sankyo initiates Phase III trial of edoxaban in reducing recurrent VTE complications

FMCNA ships dialysis machines and supplies for Haiti relief efforts

Excelsior Medical donates medical supplies to support Haiti earthquake relief effort

New report illustrates why cardiovascular disease is under-recognized and under-treated in women

GIVI scientists discover anti-HIV molecule that enhances infection, reduces transmission

Gore introduces PROPATEN Vascular Grafts with Integrated Rings

PolyMedix completes first two segments of its PMX-30063 antibiotic drug candidate Phase 1B study

New guidelines on the management of antithrombotic agents for endoscopic procedures published

Generic erosion of premium-priced branded agents to offset sales of new agents

PolyMedix to present data on its heptagonist compounds

Dabigatran etexilate prevents recurrent VTE with less bleeding than warfarin

Anticoagulants used to prevent clots in placental blood vessels ineffective, reveals research

New discoveries to treat life-threatening blood disorder presented at ASH annual meeting

ISIS-FXIRx and ISIS-SMNRx included in Isis Pharmaceuticals' development pipeline

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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