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Newly appointed NIH director includes global health on priority list

Francis Collins, the newly appointed director of the NIH on Monday outlined his top five priorities for the U.S. research agency during a town hall meeting with NIH staff, Science's blog "Science Insider" reports. Collins emphasized the agency's commitment to "high-throughput technologies," "translational research," "health care reform," "global health" and "empower[ing] the biomedical research community," the blog writes (Kaiser, 8/17).

19 Aug 2009

New software programs improve the cancer biomarker identification process

caCORRECT and omniBioMarker programs earn silver-level compatibility certification from NIH/National Cancer Institute's cancer Bioinformatics Grid

19 Aug 2009

Labcyte awarded 2nd Japanese patent for acoustic-based cell sorting system

Labcyte, the company that developed and commercialized the acoustic transfer of liquids today announced that the Japanese patent office has granted patent 4309131 that covers the design of an acoustic-based system that can sort cells based upon acoustic or other properties and then eject them specifically from a mixed population.

18 Aug 2009

Discovery of compounds that selectively kills cancer stem cells

The cancer stem cells that drive tumor growth and resist chemotherapies and radiation treatments that kill other cancer cells aren't invincible after all. Researchers reporting online on August 13th in the journal Cell, a Cell Press publication, have discovered the first compound that targets those cancer stem cells directly.

13 Aug 2009

Researchers tackle aggressive cancer cells head on

A multi-institutional team of Boston-area researchers has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors.

13 Aug 2009

Potential new antibiotics tested in pinhead-sized worms

In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics. Their study appeared in ACS Chemical Biology, a monthly journal.

6 Aug 2009

Innovative diabetes drug discovery partnership

The Juvenile Diabetes Research Foundation said today that it has entered into a novel collaborative research agreement with the Genomics Institute of the Novartis Research Foundation (GNF) to create a diabetes drug discovery and development platform.

5 Aug 2009

Scientists develop microfabricated device to measure cellular forces during tissue development

A University of Pennsylvania-led collaboration of bioengineers studying the physical forces generated by individual cells has created a tiny micron-sized device that allows researchers to measure and manipulate cellular forces as assemblies of living cells reorganize themselves into tissues.

23 Jun 2009

Search for prostate cancer biomarkers continues

Collaboration in prostate cancer translational research in Europe is not only vital to sustain the progress achieved in recent years but also to streamline current efforts between researchers and clinicians and avoid duplication or overlaps. This was amongst the goals of the two-day Prostate Cancer Translational Research in Europe (PCTRE) Meeting which opened today in Amsterdam, The Netherlands.

23 Jun 2009

Genome-wide map shows precisely where microRNAs do their work

MicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with such wide-ranging applications as onions that can't make you cry and therapeutic potential for new treatments for viral infections, cancer and degenerative diseases. But the question remains: How do they work?

17 Jun 2009

Plant microbe shares features with drug-resistant pathogen - implications for biotech

An international team of scientists has discovered extensive similarities between a strain of bacteria commonly associated with plants and one increasingly linked to opportunistic infections in hospital patients. The findings suggest caution in the use of the plant-associated strain for a range of biotech applications. The genetic analysis was conducted in part at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, and will be published in the July 2009 issue of Nature Reviews Microbiology, now available online.

16 Jun 2009

Scientists launch Gene Expression Atlas

Today, researchers at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) launch a new database, the Gene Expression Atlas, which allows scientists to search and compare gene expression data at unprecedented detail and scope. Observing how gene expression varies in different cell types, tissues and under disease conditions can help researchers understand gene function and to develop new drugs and therapies.

15 Jun 2009

Discovery of new arenavirus associated with hemorrhagic fever – first identified in nearly four decades

Scientists at Columbia University's Mailman School of Public Health, the South African National Institute for Communicable Diseases of National Health Laboratory Service (NICD-NHLS), the U.S. Centers for Disease Control and Prevention, and Roche's 454 Life Sciences Corporation have discovered the new virus responsible for a highly fatal hemorrhagic fever outbreak in Zambia and South Africa in late 2008.

2 Jun 2009

NIH to develop therapeutics for rare and neglected diseases

The National Institutes of Health is launching the first integrated, drug development pipeline to produce new treatments for rare and neglected diseases. The $24 million program jumpstarts a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases program, or TRND.

20 May 2009

University of Liverpool awarded £2.2 million for genomics hub

The University of Liverpool has been awarded £2.2 million to establish a high-throughput genomic analysis hub for the North of England.

13 May 2009

NCI plan to speed cancer research

At the American Association for Cancer Research 100th Annual Meeting 2009 in Denver, National Cancer Institute (NCI) Director John E. Niederhuber, M.D., announced major details, such as funding more grants, development of a platform for personalized cancer care, and an accelerated cancer genetics program, that will move cancer research forward in this new economic environment.

20 Apr 2009

First compound for receptors in schizophrenia and Alzheimer's holds promise

For almost 20 years, pharmacological companies have known that certain compounds that activate two specific CNS receptors, causing them to release the neurotransmitter acetylcholine, are effective in treating the cognitive and motor problems related to both schizophrenia and Alzheimer's disease (AD).

20 Apr 2009

Fluorescent anesthetic compound brings new avenues for drug discovery

A collaboration of University of Pennsylvania and University of Wisconsin chemists and anesthesiologists have identified a fluorescent anesthetic compound that will assist researchers in obtaining more precise information about how anesthetics work in the body and will provide a means to more rapidly test new anesthetic compounds in the search for safer and more effective drugs.

6 Apr 2009

New cancer genomics web-based tools provide researchers a powerful new to visualize and analyze data

A Cancer Genomics Browser developed by researchers at the University of California, Santa Cruz, provides a new way to visualize and analyze data from studies aimed at improving cancer treatment by unraveling the complex genetic roots of the disease.

30 Mar 2009

New high-throughput screening technique makes probing puzzling proteins possible

Understanding the tens of thousands of proteins that compose the human proteome has emerged as a key challenge of this century, and research efforts to date have already enabled major advances in drug discovery and understanding basic biology.

29 Mar 2009