High Throughput Sequencing News and Research

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High-throughput sequencing can detect early signs of leukemia relapse

A study led by researchers at Fred Hutchinson Cancer Research Center has found that a next-generation, high-speed DNA-decoding technology called high-throughput sequencing can detect the earliest signs of potential relapse in nearly twice the number of leukemia patients as compared to flow cytometry, the current gold standard for detecting minimal residual disease.

17 May 2012

Eating pistachios may help alter levels of beneficial bacteria in the gut

A preliminary 16-person study suggests that eating pistachios may help alter levels of potentially beneficial bacteria in the gut, a finding that holds promise for supporting digestive health. The research, presented as an abstract this week at the Experimental Biology conference, is the first study of pistachios and almonds and their modulating role on the gut microbiota composition.

25 Apr 2012

New DNA-reading technology could lead to correct genetic diagnosis for muscle-wasting diseases

Scientists at The University of Nottingham have used a revolutionary new DNA-reading technology for a research project that could lead to correct genetic diagnosis for muscle-wasting diseases.

6 Mar 2012

Study describes how multiple RNA binding proteins cooperatively control genetic splicing code

Understanding how RNA binding proteins control the genetic splicing code is fundamental to human biology and disease - much like editing film can change a movie scene. Abnormal variations in splicing are often implicated in cancer and genetic neurodegenerative disorders.

17 Feb 2012

EU-funded 4DCellFate project to kick off today

Today European scientists are meeting to kick off the 4DCellFate project, funded by the European Commission under the FP7 program.

13 Feb 2012

Damon Runyon Cancer Research Foundation names 18 new Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 18 new Damon Runyon Fellows at its fall Fellowship Award Committee review.

11 Jan 2012

Cancer researchers create catalog of possible targets for new treatments

As cancer researchers continue to identify genetic mutations driving different cancer subtypes, they are also creating a catalog of possible targets for new treatments.

1 Dec 2011

Roche NimbleGen, BGI develop Major Histocompatibility Complex region capture technology

Roche NimbleGen, Inc. and BGI, the world's largest genomic organization, announced that they have developed a Major Histocompatibility Complex (MHC) region capture technology based on NimbleGen SeqCap EZ Choice Library, a revolutionary process for the enrichment of the MHC region.

28 Nov 2011

U of U researchers receive NIH grant to uncover viral cause of MS

A team of investigators from the University of Utah has received a two-year, $275,000 grant from the National Institutes of Health (NIH) to fund novel research that may help to uncover a viral cause for the most acute and severe form of multiple sclerosis.

13 Oct 2011

Close link between SF3B1 mutation and specific feature of myelodysplastic syndromes

Geneticists have discovered that a gene involved in the modification of ribonucleic acid (RNA) is mutated in a significant proportion of people with a collection of blood cancers called myelodysplastic syndromes.

27 Sep 2011

Study may help explain plague's rapid evolution and aid in development of therapeutics

In the evolutionary blink of an eye, a bacterium that causes mild stomach irritation evolved into a deadly assassin responsible for the most devastating pandemics in human history. How did the mild-mannered Yersinia pseudotuberculosis become Yersinia pestis, more commonly known as the Plague?

30 Aug 2011

Gut microflora may influence obesity treatments

Obesity in the United States is reaching ever more alarming proportions, posing a severe menace to public health and exacerbating a crisis in health care costs both domestically and worldwide.

27 Jul 2011

454 Life Sciences launches new GS FLX+ System for high-throughput sequencing

454 Life Sciences, a Roche Company, announced today the launch and immediate availability of the new GS FLX+ System, an instrument capable of generating extra-long sequencing reads up to 1,000 by in length.

28 Jun 2011

CLC bio, AROS partner to provide 'Total Genomic Solutions'

Today, CLC bio announced its collaboration with one of the premier European service providers, GLP and GCP certified AROS Applied Biotechnology who specialize in Total Genomic Solutions, covering all steps from extraction, sample banking, and analysis, to advanced bioinformatics using CLC bio's enterprise platform.

8 Jun 2011

NuGEN, Roche develop unique genomic sample preparation solutions

454 Life Sciences, a Roche Company, and NuGEN Technologies, announced today the development of a unique sample preparation method and high-throughput sequencing solution for small and degraded RNA samples.

6 Apr 2011

CCCB selects CLC bio's enterprise platform for next generation sequence analysis

After a thorough head-to-head evaluation against various competing solutions, the Center for Cancer Computational Biology at the Dana-Farber Cancer Institute has selected CLC bio's enterprise platform for next generation sequence analysis.

8 Mar 2011

Scientists sequence Clostridium botulinum genome that produces neurotoxin

Scientists on the Norwich Research Park have sequenced the genome of a novel strain of Clostridium botulinum, one of the most dangerous pathogens known to man. The strain produces an unusual botulinum neurotoxin, known as type A5 neurotoxin, which was isolated by the Health Protection Agency, following a case of wound botulism.

8 Mar 2011

Covaris, Caliper enter co-marketing agreement to leverage next generation sequencing

Caliper Life Sciences, Inc. and Covaris Inc., Woburn, Mass., today announced a co-marketing agreement which will leverage Covaris' acoustic DNA shearing platforms and Caliper's automation and microfluidics technologies to develop automated workflows for next generation sequencing experiments.

24 Feb 2011

CLC bio, Omixon release SOLiD Alignment plug-in for high-throughput sequencing data analysis

Today, CLC bio and Omixon announced the release of the Omixon Gapped SOLiD Alignment plug-in for full integration into CLC Genomics Workbench.

8 Feb 2011

CLC bio releases Version 4.5 of CLC Genomics Workbench

Today, CLC bio announced the release of CLC bio's premier desktop software package for working with genomics, transcriptomics, and epigenomics: Version 4.5 of CLC Genomics Workbench - an update which gives molecular biologists access to analyze high-througput sequencing datasets with powerful bioinformatics algorithms through a user-friendly graphical user-interface.

4 Feb 2011