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Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

18 May 2020

Are overactive immune cells causing COVID-19-related deaths?

While the COVID-19 pandemic is devastating many regions, the world over, a new paper published in the Journal of Experimental Medicine in April 2020 describes the possibility that the critical or very severe cases of COVID-19 are due to the production of neutrophil extracellular traps (NET) due to hyperactivated immune cells.

16 Apr 2020

Scientists uncover key molecular mechanism underlying different aspects of sepsis

Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment.

27 Mar 2020

Diet affects sperm and the health of offspring

A new study published in the journal Molecular Cell, in March 2020, reports that parental diet is a crucial factor in the future metabolic health of the offspring.

19 Mar 2020

Bacteria-trapping protein may contribute to breast cancer metastasis

The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

19 Mar 2020

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

A sperm enters an egg, an embryo develops and eventually a baby is born. But back up a second -- how does the mother's half-genome actually merge with the father's half-genome to form one new human genome?

13 Mar 2020

New mechanism for repair of chromosomal breaks

Chromosomal breaks are the most harmful damage for cells. If they are not repaired, they block the duplication and segregation of chromosomes, stop the growth cycle and cause cell death. These breaks appear frequently in tumor cells and are produced spontaneously during the replication of genetic material.

10 Feb 2020

BPA activates immune response in mice that persists for at least three generations

Some plastic food and beverage containers still contain bisphenol A, which can mimic the hormone estrogen. Although experts say that small amounts of BPA detected in foods are unlikely to cause problems, some people worry that constant low-level exposures could have health effects, especially for developing fetuses, infants and children.

16 Jan 2020

Study shows how immune cells quickly switch to attack mode

Macrophages have two faces: In healthy tissue, they perform important tasks and support their environment. However during an infection, they stop this work and hunt down the pathogens instead.

17 Dec 2019

Penn researchers track defective sperm epigenome linked to male infertility

One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm that fail to "evict" proteins called histones from DNA during development.

16 Dec 2019

Important discovery about male infertility could lead to new treatments

Using a new mouse model, Penn Medicine researchers have identified defects in the sperm epigenome that cause male infertility.

16 Dec 2019

Harvard scientists demonstrate possible strategy for achieving herpes virus control

The herpes simplex virus, commonly known as the cold sore virus, is a devious microbe.

12 Dec 2019

Epigenomic techniques used to fight disease

Humans differ from one another in many ways, including how they react to disease, because of their DNA blueprint, as well as the difference in the environments they face. These factors combine to make each person unique. Now a new study published in the journal Nature Protocols reports the development of a promising technology to uncover the process by which the body fights diseases in different ways.

4 Dec 2019

Researchers identify a promising drug pair to attack deadly childhood brain cancers

Researchers have devised a new plan of attack against a group of deadly childhood brain cancers collectively called diffuse midline gliomas, including diffuse intrinsic pontine glioma, thalamic glioma and spinal cord glioma.

20 Nov 2019

Study reveals key mechanism that helps cells to adapt to low-nutrient conditions

Scientists from the UNC School of Medicine and Stanford University have uncovered what may be a fundamental biological mechanism that helps organisms adapt to rapid changes to nutrients in their environments.

6 Nov 2019

Researchers discover new process of antitumor response of NK cells in myeloma

NK cells mean Natural Killer cells. They are part of the innate immune system. They are known primarily for their ability to recognize and kill tumor cells, cells infected by viruses and bacteria, or dying by apoptosis. Although evidence about their antitumoral capacity, how this activity occurred remained unknown.

5 Nov 2019

Histones News and Research

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

Are overactive immune cells causing COVID-19-related deaths?

Scientists uncover key molecular mechanism underlying different aspects of sepsis

Diet affects sperm and the health of offspring

Bacteria-trapping protein may contribute to breast cancer metastasis

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

New mechanism for repair of chromosomal breaks

BPA activates immune response in mice that persists for at least three generations

Study shows how immune cells quickly switch to attack mode

Penn researchers track defective sperm epigenome linked to male infertility

Important discovery about male infertility could lead to new treatments

Harvard scientists demonstrate possible strategy for achieving herpes virus control

Epigenomic techniques used to fight disease

Researchers identify a promising drug pair to attack deadly childhood brain cancers

Study reveals key mechanism that helps cells to adapt to low-nutrient conditions

Researchers discover new process of antitumor response of NK cells in myeloma

Mechanisms preserving cell identity are based on status of proteins housing DNA

Acetate derived from alcohol metabolism directly influences epigenetic regulation in the brain

UChicago researchers reveal the secret of cancer-related Warburg effect

Subtle changes in mitochondrial DNA can have profound consequences for patient's health

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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