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Effects of hybrid immunity on humoral immune response following COVID mRNA vaccination in a cohort of essential and frontline workers

Researchers longitudinally evaluated humoral immune responses to the second and third doses of COVID-19 mRNA vaccines among individuals with and without prior history of SARS-CoV-2 infections.

3 Jan 2023

New insights on the circadian clock of Drosophila melanogaster

The higher the temperatures, the faster physiological processes are. But there is an exception: the so-called circadian clock, which regulates the sleep-wake cycle in organisms.

30 Dec 2022

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Researchers described a messenger ribonucleic acid (mRNA)-lipid nanoparticle monkeypox vaccine encoding four conserved monkeypox virus surface proteins which induced monkeypox virus-specific immunity and elicited heterologous protection when challenged with lethal vaccinia virus.

23 Dec 2022

High efficacy of SARS-CoV-2 vaccines in preventing COVID-19 deaths in children and adolescents

A new study evaluated the effectiveness of coronavirus disease 2019 (COVID-19) vaccines in Argentinian children when severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron were predominant.

23 Dec 2022

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

Researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against SARS-CoV-2.

20 Dec 2022

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

Researchers demonstrated that a trivalent vaccine against SARS-CoV-2 improved the breadth of humoral immune responses in mice.

19 Dec 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

Fragment crystallizable receptor-effector functions as a key correlate for pan-sarbecovirus vaccine development

Researchers elucidated pan-sarbecovirus immune protection mechanisms by utilizing a Venezuelan equine encephalitis virus-vectored vaccine panel that covered bat strains to human strains.

30 Nov 2022

Could mRNA vaccines triumph over other viral infections in humans and domestic animals?

Researchers review potential areas for mRNA vaccine development against pathogenic viruses other than SARS-CoV-2.

28 Nov 2022

Exploring synthetic engineering of bacteriophages

In a new study, researchers demonstrated biological bacteriophage containment and synthetic engineering.

24 Nov 2022

The safety and immunogenicity of a fourth dose of NVX-CoV2373

Researchers assessed the immunogenicity and safety of a fourth homologous boost dose of a recombinant SARS-CoV-2 spike protein vaccine called NVX-CoV2373.

23 Nov 2022

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

Researchers assessed the effectiveness of SARS-CoV and SARS-CoV-2 envelope proteins against HIV-1.

22 Nov 2022

Scientists explore bat sarbecovirus isolation in Japan

Researchers performed bat sarbecovirus isolation experiments using Rhinolophus cornutus bats from several regions in Japan that were phylogenetically situated in the same cluster of viruses related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 Nov 2022

Ketogenic diet may show more promising results than Mediterranean diets in short-term type 2 diabetes management

Researchers evaluated the short-term impact of the very-low-calorie ketogenic diet (VLCKD) and Mediterranean diet (MD) on the gut microbiota (GM) of obese patients with new-onset type II diabetes (T2DM).

15 Nov 2022

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Researchers investigated the early T cell responses during SARS-CoV-2 infections to understand the mechanisms of rapid clonal expansion that characterize the T cell responses to acute infections and vaccinations.

14 Nov 2022

The viral fitness and antigenic relationship among Omicron sublineages

Researchers used mouse models and human airway cell cultures to investigate the relative viral replication rates and cross-neutralization against SARS-CoV-2 Omicron sublineages.

14 Nov 2022

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

SOPHiA GENETICS, a cloud-native software company in the healthcare space, debuted new data at the European Society of Gynaecological Oncology (ESGO) Congress as part of a poster (#PA-065) presented by Prof. Alexandre Harlé of the Institut de Cancérologie de Lorraine, France.

3 Nov 2022

New method to estimate the contribution of each amino acid residue

You can't expect a pharmaceutical scientist to switch labs to the facilities available in a television studio and expect the same research output. Enzymes behave exactly the same. But now, in a study recently published in ACS Synthetic Biology, researchers from Osaka University have imparted an analogous level of adaptability to enzymes, a goal that has remained elusive for over 30 years.

3 Nov 2022

Researchers take a cue from viruses to make glioblastoma more vulnerable to treatment

In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment.

1 Nov 2022

The impact of seasonal coronavirus immunity on susceptibility to SARS-CoV-2 infection and COVID-19 vaccination

Researchers investigated whether immunity against seasonal human coronavirus spike proteins of HKU1, OC43, NL63, or 229E could protect against SARS-CoV-2 in vitro.

28 Oct 2022