Huntington’s Disease News and Research

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Researchers look at whether creatine slows progression of Parkinson's disease

Researchers at the University of Rochester Medical Center are leading one of the largest clinical trials ever for Parkinson's disease.

25 Mar 2007

Curry related compound shows promise against Kennedy's disease

Scientists who focus on the molecular signaling that underlies prostate cancer have discovered a compound that shows promise against a debilitating neurodegenerative condition known as Kennedy's disease, which is caused by a mutant gene.

21 Mar 2007

Scientists tackle huntingtin protein

McMaster scientists are very close to defining small molecule drugs that should be able to redirect the huntingtin protein from accumulating in the wrong place within brain cells, which could potentially translate to a therapy for Huntington's Disease (HD).

29 Jan 2007

Human embryonic stem cells show potential in treating rats with Parkinson's symptoms

Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson's-like symptoms dramatically, but the treatment caused a significant problem - the appearance of brain tumors - that scientists are now working to solve.

2 Dec 2006

Researchers discover protein interaction that may explain how Huntington's disease affects the brain

The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington's protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain.

2 Dec 2006

Effective test for screening Huntington's disease drugs

A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds - memantine and riluzole - are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report.

30 Oct 2006

Researchers identify peptide that spurs cargo transport in nerve cells

For the first time, researchers have identified a peptide that can spur cargo transport in nerve cells, a discovery that could help scientists better understand nerve cell function and test possible therapies for neurodegenerative diseases.

24 Oct 2006

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

Scientists at Dana-Farber Cancer Institute report they have found how the brain turns on a system designed to protect its nerve cells from toxic "free radicals," a waste product of cell metabolism that has been implicated in some degenerative brain diseases, heart attacks, strokes, cancer, and aging.

20 Oct 2006

PGC-1 alpha implicated in Huntington's disease neurodegeneration

A metabolic disorder underlies the brain effects found in those with Huntington's disease, researchers report in an advance article publishing online October 19, 2006. The article will appear in the November 2006 issue of the journal Cell Metabolism, published by Cell Press.

20 Oct 2006

Protection for nerve cells - eating up defective proteins

Nerve cells in the Central Nervous System can defend against and recover from damage by proteinlike clusters which are associated with neurodegenerative diseases such as Huntington's Chorea.

13 Sep 2006

Green tea slows down plaque formation in Huntington's disease

Green tea can apparently inhibit the formation of the lethal protein aggregates that are a characteristic feature of Huntington's disease (HD).

13 Sep 2006

Molecular chaperones protect cells

Falsely folded proteins and their aggregations in neurons are considered to be the cause of neurodegenerative diseases, among them Chorea Huntington.

13 Sep 2006

New avenue for the pursuit of therapies for Alzheimer's disease

The genes responsible for an inherited form of Alzheimer's disease play a direct role within cells that has largely been overlooked, according to a report in the September 8, 2006 issue of the journal Cell.

7 Sep 2006

$1M Myers Fellowship brings US research techniques to Melbourne

The Howard Florey Institute's inaugural Allan and Maria Myers Travel Fellowship has been awarded to world renowned neuroscientist, Prof Gerard Shaw, from the McKnight Brain Institute, University of Florida College of Medicine.

20 Aug 2006

Skin test may help detect early Alzheimer's

A simple skin test that would allow detection of Alzheimer's disease appears to be a realistic possibility in the future.

16 Aug 2006

Prospective Huntington At Risk Observational Study

Doctors have completed the first step of a unique medical research study, evaluating 1,001 individuals at risk of developing Huntington's disease who do not know - nor do they want to know - whether they carry the genetic defect that causes the condition.

8 Aug 2006

Promising therapy for Lou Gehrig's disease delivers antisense drug directly to nervous system

Researchers have designed and tested a molecular therapy in animals that they hope will be a major development in the fight to treat amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

27 Jul 2006

Scientists characterize structure of calbindin-D28K

Scientists at North Carolina State University have effectively lifted the veil from an important protein that is linked to the prevention of neurodegenerative diseases like Alzheimer's and Huntington's.

26 Jul 2006

Pig cell implants show potential for treatment of stroke, Huntington's disease

A review of accumulated evidence on the use of porcine brain choroid plexus (CP) cells published in the July issue of Xenotransplantation highlights that these cells have the potential to treat acute and chronic brain disease.

24 Jul 2006

Scientists use embryonic stem cells to awaken latent motor nerve repair

In a dramatic display of stem cells' potential for healing, a team of Johns Hopkins scientists reports that they've engineered new, completed, fully-working motor neuron circuits - neurons stretching from spinal cord to target muscles - in paralyzed adult animals.

26 Jun 2006