Hypogonadism News and Research

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Testicular failure, also known as primary hypogonadism, is an uncommon condition that is characterized by the inability of the testicles to produce sperm and the male hormone testosterone. The are many factors that have been postulated as causes of the condition, which give rise to a wide array of signs and symptoms. These factors can sometimes make diagnosis as well as treatment of testicular failure a challenging problem.

Effects of declining sperm counts on fertility, mortality and disease patterns in geographical areas: Study

There is a lack of definitive data on the actual trends of decline in sperm counts according to researchers despite it being a known fact. Researchers in a new study looked at a large population to find the exact data regarding this scenario and its effects on the society. They looked at the effects of fertility and geographical distribution on the sperm concentration as well as total sperm counts.

25 Jul 2017

Testicular cancer survivors with low testosterone more likely to have chronic health problems

In a large study, 38% of 491 testicular cancer survivors had low testosterone levels, known as hypogonadism.

5 Jun 2017

Direct-to-consumer ‘low-T’ medication advertising increases prescriptions but may not improve health

Direct-to-consumer advertising for drugs to treat testosterone deficiency -- or "low T" -- increases prescriptions to men for hormone-replacement therapies but may not improve their health, UC Davis physician Richard Kravitz said in an editorial published in the March 21 issue of the Journal of the American Medical Association.

22 Mar 2017

Long-term use of testosterone therapy in hypogonadal men may reduce risk of death from CV disease

Despite the continued controversy surrounding the use of testosterone in men who have testosterone deficiency (hypogonadism), a new study has found that long-term use of testosterone therapy not only improves vigor and vitality, but may reduce the risk of death due to cardiovascular (CV) disease.

13 Feb 2017

Study establishes harmonized reference ranges for total testosterone in men

A large study of more than 9,000 men has established harmonized reference ranges for total testosterone in men that when applied to assays that have been appropriately calibrated will effectively enable clinicians to make a correct diagnosis of hypogonadism, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

11 Jan 2017

Geisinger physicians report opioid therapy to be ineffective in treating chronic pain

A new study by a pair of Geisinger Health System physicians reports that the use of opioid therapy to treat chronic pain is not only ineffective, it can actually increase the likelihood of more harmful consequences, including death.

8 Dec 2016

Endocrine Society issues new guidelines on hypopituitarism

The Endocrine Society today issued a Clinical Practice Guideline that recommends treating insufficient hormone levels in individuals with hypopituitarism by replacing hormones at levels as close to the body's natural patterns as possible.

13 Oct 2016

T-sol can be safe and effective treatment for men with hypogonadism

For men with hypogonadism, a condition in which the body does not produce enough testosterone, low sex drive and fatigue are common symptoms.

17 Aug 2016

Fertility problems put men at increased risk of metabolic diseases

Men with fertility problems are at risk of metabolic diseases as they age, according to work being presented at the European Association of Urology conference in Munich

14 Mar 2016

Testosterone treatment can benefit men with Type 2 diabetes

Men with Type 2 diabetes who have low testosterone levels can benefit significantly from testosterone treatment.

30 Nov 2015

Study shows restoring testosterone production in men does not impact their fertility

Restoring testosterone production in men may be as effective as replacing it, without compromising their fertility. Two phase III clinical trials show that a drug that restores the body’s natural production of testosterone has no negative effect on a man’s sperm count while a topical testosterone gel causes a significant drop.

28 Oct 2015

Men referred for borderline testosterone levels have much higher rates of depression than general population

Researchers at the George Washington University, led by Michael S. Irwig, M.D., found that men referred for tertiary care for borderline testosterone levels had much higher rates of depression and depressive symptoms than those of the general population.

2 Jul 2015

Men who use finasteride to treat benign prostate enlargement experience worsening ED

Men with benign prostate enlargement who used finasteride (also known as proscar and propecia) to treat their condition, experienced worsening erectile dysfunction (ED) that did not resolve with continued treatment. In addition, they experienced a reduction in their testosterone levels leading to hypogonadism (little to no production of sex hormones).

14 Jun 2015

New imaging technique may improve testicular sperm extraction, reduce trauma during surgery

In the middle of Europe nearly every sixth couple in the reproductive age is involuntarily childless, in 50% due to male infertility. In about 10% of all infertile men azoospermia is diagnosed, i.e. no spermatozoa are found in the ejaculate.

30 May 2015

Endo announces commercial availability of NATESTO nasal gel for men with hypogonadism

Endo Pharmaceuticals Inc., a subsidiary of Endo International plc (NASDAQ: ENDP) (TSX: ENL), announced today the commercial availability of NATESTO (testosterone nasal gel), the first and only nasal gel for testosterone replacement therapy in adult males diagnosed with hypogonadism.

16 Mar 2015

Men with borderline testosterone levels have higher rates of depression, new research finds

Men with borderline testosterone levels have higher rates of depression and depressive symptoms than the general population, new research finds.

9 Mar 2015

Letrozole helps restore fertility in obese, infertile men

A letrozole pill once a week restored fertility in obese, infertile men and led to their partners giving birth to two full-term, healthy babies, according to a new study from Canada. The results will be presented Thursday at the Endocrine Society's 97th annual meeting in San Diego.

9 Mar 2015

Phase 3 trial results show that new testosterone nasal gel is effective and practical

A new testosterone nasal gel raises men's low testosterone levels to normal, with few side effects, according to the results of a phase 3 clinical trial to be presented Saturday at the Endocrine Society's 97th annual meeting in San Diego.

9 Mar 2015

Endocrinologist examines benefits and harms of testosterone therapy

An article in the latest edition of Australian Prescriber looks at the prescribing of testosterone, often used for ‘male menopause’ symptoms such as reduced energy, poor concentration and increased body fat. Over the past decade there has been a steep rise in the amount of testosterone dispensed in Australia and globally.

4 Dec 2014

Exome sequencing refines 46,XY DSD diagnosis

Exome sequencing can identify a likely genetic cause of 46,XY disorders of sex development in about a third of cases, report researchers.

1 Dec 2014

Hypogonadism News and Research

Further Reading

Effects of declining sperm counts on fertility, mortality and disease patterns in geographical areas: Study

Testicular cancer survivors with low testosterone more likely to have chronic health problems

Direct-to-consumer ‘low-T’ medication advertising increases prescriptions but may not improve health

Long-term use of testosterone therapy in hypogonadal men may reduce risk of death from CV disease

Study establishes harmonized reference ranges for total testosterone in men

Geisinger physicians report opioid therapy to be ineffective in treating chronic pain

Endocrine Society issues new guidelines on hypopituitarism

T-sol can be safe and effective treatment for men with hypogonadism

Fertility problems put men at increased risk of metabolic diseases

Testosterone treatment can benefit men with Type 2 diabetes

Study shows restoring testosterone production in men does not impact their fertility

Men referred for borderline testosterone levels have much higher rates of depression than general population

Men who use finasteride to treat benign prostate enlargement experience worsening ED

New imaging technique may improve testicular sperm extraction, reduce trauma during surgery

Endo announces commercial availability of NATESTO nasal gel for men with hypogonadism

Men with borderline testosterone levels have higher rates of depression, new research finds

Letrozole helps restore fertility in obese, infertile men

Phase 3 trial results show that new testosterone nasal gel is effective and practical

Endocrinologist examines benefits and harms of testosterone therapy

Exome sequencing refines 46,XY DSD diagnosis

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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