Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Researchers provide new insights into the vexing process that makes HIV stealthy

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.

14 Nov 2022

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Researchers investigated the early T cell responses during SARS-CoV-2 infections to understand the mechanisms of rapid clonal expansion that characterize the T cell responses to acute infections and vaccinations.

14 Nov 2022

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.

14 Nov 2022

How lessons from the HIV epidemic can help combat COVID-19

Researchers revisit lessons learned from the HIV pandemic in response to COVID-19.

13 Nov 2022

People living with HIV found to have a significantly delayed internal body clock

People living with HIV have a significantly delayed internal body clock, consistent with the symptoms of jet lag, according to new findings reported by researchers from universities in South Africa and the UK.

10 Nov 2022

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Researchers used a deep antibody-antigen interaction (DeepAAI) algorithm to understand the antibody representations of unseen antibodies to accelerate the discovery of novel antibodies with potential therapeutic applications.

9 Nov 2022

Mortality rate and risk among hospitalized COVID-19 patients during different surges of the pandemic

Researchers assessed the mortality rates associated with SARS-CoV-2 Alpha (B.1.1.7) and Delta (B.1.617.2) variant infections.

9 Nov 2022

Modeling predicts a declining trend in monkeypox cases globally and on a country-specific scale

In a recent study posted to the medRxiv* server, researchers at Georgia State University, USA, generated short-term forecasts of new monkeypox cases using an ensemble and subepidemic model.

7 Nov 2022

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Researchers identified a genetic association signal, via genome-wide association studies, between severe COVID-19 with systemic lupus erythematosus, an autoimmune disease.

7 Nov 2022

Persistent COVID-19 symptoms among South Africans infected during SARS-CoV-2 Beta, Delta and Omicron variant waves

Researchers longitudinally followed up hospitalized (H) and non-hospitalized (NH) COVID-19 patients for six months after laboratory-confirmed SARS-CoV-2 infections to identify factors that increase the risk of post-COVID-19 condition development in the South African population.

4 Nov 2022

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

A new study aimed to analyze the molecular interactions between the hCypA protein and the SARS-CoV-2 variants to determine the impact of variants on the blocking and binding potential of the hCypA–S protein complex with the ACE2 receptor.

2 Nov 2022

The maternal RSV vaccine from Pfizer protects newborns against severe illness

Pfizer announced its maternal vaccine against RSV to be almost 82% effective in protecting infants for the first 90 days of life against severe illness.

1 Nov 2022

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

Researchers demonstrated how interferon-stimulated gene 15 (ISG15) is involved in the Vaccinia virus (VACV) dissemination.

1 Nov 2022

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

In a new study, researchers assessed the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV envelope (E) proteins on human immunodeficiency virus type 1 (HIV-1) infectivity.

31 Oct 2022

Lower risk of colorectal cancer associated with dietary flavanone and anthocyanidin intake, according to new research

In a new study, researchers assessed the risk of colorectal cancer (CRC) with the intake of flavonoids.

31 Oct 2022

New report on the impact of monkeypox on people with HIV

Researchers describe the presentation of patients severely infected with the monkeypox virus.

30 Oct 2022

SARS-CoV-2 infection can affect menstruation

Researchers assess the association between SARS-CoV-2 infection and menstrual irregularities.

30 Oct 2022

Study reports on a novel property of antibodies, light chain coherence

Researchers investigate whether pairs of unrelated B-cells that have similar heavy chains also have the same light chains.

30 Oct 2022

Low-density granulocytes are phenotypically altered in people with long-COVID

In a recent study posted to the bioRxiv* preprint server, researchers characterized low-density granulocyte (LDG) neutrophil (NP) proportion among individuals up to 14 months post-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection.

28 Oct 2022

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, an international team of researchers leveraged the human light chain apoferritin protomer-derived MULTI-specific, multi-Affinity antibody (Multabody, MB) platform for the generation of broad and potent SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)-neutralizing antibodies (Abs).

27 Oct 2022

Immunodeficiency News and Research

Further Reading

Researchers provide new insights into the vexing process that makes HIV stealthy

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

How lessons from the HIV epidemic can help combat COVID-19

People living with HIV found to have a significantly delayed internal body clock

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Mortality rate and risk among hospitalized COVID-19 patients during different surges of the pandemic

Modeling predicts a declining trend in monkeypox cases globally and on a country-specific scale

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Persistent COVID-19 symptoms among South Africans infected during SARS-CoV-2 Beta, Delta and Omicron variant waves

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

The maternal RSV vaccine from Pfizer protects newborns against severe illness

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

Lower risk of colorectal cancer associated with dietary flavanone and anthocyanidin intake, according to new research

New report on the impact of monkeypox on people with HIV

SARS-CoV-2 infection can affect menstruation

Study reports on a novel property of antibodies, light chain coherence

Low-density granulocytes are phenotypically altered in people with long-COVID

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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