Immunodeficiency News and Research

RSS

Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Combination therapy shows promise in targeting latent HIV reservoirs

Antiretroviral therapies (ART) stop HIV replication in its tracks, allowing people with HIV to live relatively normal lives.

15 Feb 2024

U of M research offers new avenue of hope in the fight against chronic HIV

Published in the Journal of Infectious Diseases Oxford Academic, research led by the University of Minnesota Medical School offers a new avenue of hope in the fight against chronic human immunodeficiency virus (HIV) infection.

14 Feb 2024

Vaccines safe for pregnant women with HIV but show reduced immune response

A meta-analysis in eClinicalMedicine finds vaccines are safe for pregnant women living with HIV, showing reduced immunogenicity compared to those without HIV but no increase in adverse events, highlighting the need for their inclusion in vaccine trials.

9 Feb 2024

Paxlovid enhances treatment options for COVID-19 patients

The design, synthesis, and mechanism of action of Paxlovid.

6 Feb 2024

Syphilis: A silent epidemic reawakens

Study reports a significant increase in syphilis cases in India, highlighting the need for effective prevention and treatment despite the availability of effective therapies.

31 Jan 2024

Immunocompromised patients show prolonged SARS-CoV-2 infection and unique mutations

study identifies risk factors for prolonged SARS-CoV-2 infection in immunocompromised patients, revealing that B-cell dysfunction, solid organ transplantation, and AIDS lead to longer infections and unique spike mutations.

31 Jan 2024

HIV virus found to possess hidden transport ability

Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year.

27 Jan 2024

Do yellow fever vaccines truly provide effective lifelong protection against the disease after a single dose?

The long-term protection offered by one dose of vaccine against yellow fever.

25 Jan 2024

Study addresses knowledge gap of clinical features and outcomes of Black patients with melanoma

Researchers identified patient- and tumor-level melanoma features in black individuals.

25 Jan 2024

New study reveals key tissues involved in HIV rebound after treatment

In findings that have implications for potential new HIV therapies, researchers from Texas Biomedical Research Institute (Texas Biomed) used genetic sequencing techniques on the nonhuman primate version of the virus to identify that lymph nodes in the abdomen are the leading source of rebound infection after the first week of stopping antiretroviral treatment.

24 Jan 2024

Nutrition's pivotal role in combating tuberculosis: addressing N-AIDS for better outcomes

Review highlights the critical role of nutritionally acquired immunodeficiency syndrome (N-AIDS) in tuberculosis (TB) management, emphasizing the need for integrated nutritional screening and care in TB programs.

18 Jan 2024

Global mortality trends reveal convergence clubs and diverging patterns

Study analyzes global mortality trends from 1990 to 2030, identifying five convergence clubs of countries with similar mortality characteristics, revealing patterns of convergence and divergence in mortality and longevity.

18 Jan 2024

Study finds that HIV populations in people with higher viral loads also have higher rates of viral recombination

Researchers investigated whether denser intrahost HIV populations had a higher incidence of coinfection and recombination.

15 Jan 2024

Paxlovid treatment in 20% of COVID-19 patients could avert 850,000 hospitalizations, save up to $170 billion

A study in the Emerging Infectious Diseases journal shows treating 20% of COVID-19 patients with Paxlovid could save up to 0.85 million lives and reduce the economic burden by US $170.17 billion in the US.

14 Jan 2024

Leveraging nutritional interventions for effective TB control

Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone.

13 Jan 2024

Extended liver preservation technique shows promise for daytime transplants

Phase II clinical trial evaluates the safety and feasibility of prolonged DHOPE for extending human donor liver preservation to 20 hours, showing potential for facilitating daytime liver transplantation.

11 Jan 2024

CRISPR cures on the horizon: Breakthrough center aims to heal rare, deadly genetic diseases

Children and adults with rare, deadly genetic diseases have fresh hope for curative therapies, thanks to a new collaboration between the Innovative Genomics Institute (IGI) and Danaher Corporation, a global life sciences and diagnostics innovator.

9 Jan 2024

Fruit fly research solves human disease and fuels new cancer immunotherapy approach

Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency.

5 Jan 2024

Stapled lipopeptides show promise as broad-spectrum antiviral agents

Compounds that obstruct the "landing gear" of a range of harmful viruses can successfully protect against infection by the virus that causes COVID-19, a study published today and led by Dana-Farber Cancer Institute scientists shows.