Immunoglobulin News and Research

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Two genes play vital roles in malignant brain cancer

Two genes play important roles for the formation of malignant cancer in the brain. One gene prevents the formation of the tumor, while another gene promotes the tumor. This is shown in a new dissertation at Umeå University, Sweden.

24 May 2018

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Alexo Therapeutics, a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, today announced it has initiated ALX148 combination dosing with targeted antibody therapies in its Phase 1 clinical program in patients with advanced solid tumors and lymphoma.

17 May 2018

Prenatal test to determine child's rhesus factor found to be reliable, but benefit is unclear

If the blood of a pregnant woman is rhesus-negative and the blood of the fetus is rhesus-positive, the woman may develop antibodies, which can cause severe harm to subsequent children in particular.

16 May 2018

New test developed for accurate and safe diagnosis of peanut allergies

Researchers from the School of Immunology & Microbial Sciences and the Medical Research Council have developed a new test to diagnose peanut allergy.

14 May 2018

New research illustrates how beneficial bacteria establish robust gut colonization

The mammalian gut is warm, moist, and incredibly nutrient-rich--an environment that is perfect for bacterial growth. The communities of "good bacteria" in the gut, commonly referred to as the microbiome, are vital partners for the body, helping to digest fiber, extract nutrients, and prevent various diseases.

4 May 2018

Mother's milk found to have SWAT team of immune cells

Immune cells that are ready to take action against invaders like bacteria have been found in women's breast milk, researchers say.

3 May 2018

New award will help research into immune system differences that trigger food allergies

Adora A. Lin, M.D., Ph.D., an attending physician in Children's department of Allergy and Immunology, was awarded $240,000 to improve understanding of how children's immune systems tolerate or react to certain food allergens--sometimes triggering a cascade of side effects that can be fatal.

13 Apr 2018

Nanotechnology-based treatment approach shown to be effective in mouse models of lung cancer

The most common type of lung cancer, non-small cell lung cancer (NSCLC), continues to be difficult to treat, with five year survival rates of about 36 percent for stage 3A tumors.

11 Apr 2018

New test detects Zika antibodies with high specificity

A test that detects antibodies against Zika virus in samples of blood serum with high specificity - and hence a low risk of cross-reaction with related microorganisms such as dengue virus - is set to come on to the Brazilian market before 2018 is out.

28 Mar 2018

Blood donor scraps help researchers to discover new insight into human immune system

Iowa State University researchers have discovered new insight into the human immune system from an unlikely source, the leftover material from blood donation banks.

16 Mar 2018

Protein pathways linked to heart disease, diabetic complications identified in patients with diabetes

Protein pathways that are closely linked to changes in both triglyceride and hemoglobin A1c levels in diabetic patients have been identified in new research by the Intermountain Medical Center Heart Institute in Salt Lake City.

12 Mar 2018

Early and targeted treatment of dnDSA preserves allograft function

Development of de novo donor-specific antibodies (dnDSA) is known to cause graft failure. Therefore, a protocol aimed at prospective monitoring and treating dnDSA--before it can cause graft damage--was developed for kidney transplant recipients at Children National Health System.

5 Feb 2018

Study finds new mechanism regulating giant protein essential for muscle and heart function

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III and Columbia University in New York have discovered an important mechanism in the regulation of a protein that plays an essential role in the function of skeletal muscle and the heart.

12 Jan 2018

St. Jude gene therapy offers hope for infants with 'bubble boy' disease

Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder.

11 Dec 2017

Study suggests novel approach to predict respiratory allergy in children

A new study in EBioMedicine by researchers at Karolinska Institutet in Sweden and the Medical University of Vienna, Austria suggests that immune response in early childhood to a handful of allergen molecules can predict the onset of allergic rhinitis and asthma in adolescence.

4 Dec 2017

Scientists use computer analysis to complete antibody blueprint

Antibodies defend our bodies against intruders. These molecules consist of proteins with attached sugars. However, the blueprint directing the processing of these sugars on the protein was not well understood until now.

30 Nov 2017

Scientists suggest possibility of naturally acquired immunity against Zika infection

Birth defects in babies born infected with Zika virus remain a major health concern. Now, scientists suggest the possibility that some women in high-risk Zika regions may already be protected and not know it.

16 Nov 2017

MGH researchers identify first effective treatment option for autoimmune small-fiber polyneuropathy

An analysis of the medical records of patients treated at Massachusetts General Hospital (MGH) for an often-mysterious condition involving damage to small nerve fibers supports the hypothesis that some cases are caused by autoimmune disease and also identifies the first effective treatment option.

9 Nov 2017

MRI and ultrasound can detect fetal brain damage caused by Zika in utero

Clinicians managing Zika-affected pregnancies should use magnetic resonance imaging (MRI) in addition to standard ultrasound (US) because the more detailed MRI images can reveal more extensive areas of damage to the developing fetal brain, according to research presented during IDWeek 2017.

4 Oct 2017

Researchers propose new treatment strategy for colon cancer patients

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. In a new study, researchers demonstrate for the first time that a previously uncharacterized protein is increased in colon cancer. The protein is immunoglobulin containing proline rich receptor-1 (IGPR-1) which was recently identified in the same laboratory as a cell adhesion molecule.

20 Sep 2017