Immunohistochemistry News and Research

RSS

Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

ISO 13485:2003 certification for Advanced Cell Diagnostics

Advanced Cell Diagnostics, Inc. (ACD), a global technology and market leader in in situ nucleic acid detection for life science research and clinical diagnostics, has been granted ISO 13485:2003 certification, an international quality standard for medical devices, paving a path for ACD to launch its CE marked diagnostic tests in Europe.

From Advanced Cell Diagnostics 11 Aug 2014

Study provides platform for detailed study of nerve injury and repair during Wallerian degeneration

Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription factor activation, immune response, myelin cell differentiation and dedifferentiation.

31 Jul 2014

ROS1 fusion genes found in young East Asian patients with lung adenocarcinoma

ROS1 fusion genes were successfully detected independent of gender or smoking history in young East Asian patients with lung adenocarcinoma, a histological subgroup in non-small cell lung cancer (NSCLC), using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) diagnostic tests.

22 Jul 2014

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

NANOG gene linked to tumours derived from stratified epithelia

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia-those that form part of the epidermis of the skin or cover the oesophagus or the vagina-in adult organisms.

10 Jul 2014

Biomarkers help resolve differential diagnosis between MPM and non-cancerous pleural tissue

Scientists have identified four biomarkers that may help resolve the difficult differential diagnosis between malignant pleural mesothelioma (MPM) and non-cancerous pleural tissue with reactive mesothelial proliferations (RMPs).

6 Jun 2014

New investigational immunotherapy benefits people with advanced urothelial bladder cancer

A new investigational immunotherapy MPDL3280A has been shown to shrink tumours in 43% of people (13/30) who had previously been treated for advanced urothelial bladder cancer (UBC) with a specific type of tumour (PD-L1 positive).

3 Jun 2014

New data highlights molecular profiling in guiding treatment of patients with gynecologic malignancies

Caris Life Sciences®, a leading biosciences company focused on fulfilling the promise of precision medicine, announced today the presentation of clinical data from studies demonstrating the potential utility of comprehensive molecular profiling in guiding treatment of patients with gynecologic malignancies, including breast cancers and ovarian cancer.

31 May 2014

CTR1 may be required for successful platinum-based therapy in NSCLC

Tumours with undetectable levels of the copper transporter CTR1 have a significantly reduced response to platinum-based chemotherapy for non-small-cell lung cancer, study findings indicate.

19 May 2014

NSHOA and Caris Life Sciences collaborate to establish personalized cancer care program

North Shore Hematology Oncology Associates and Caris Life Sciences today announced a collaboration to establish a personalized cancer care program for patients in the greater Long Island area.

12 May 2014

Leica and Affymetrix launch fully automated RNA in situ hybridization assays

Affymetrix, Inc. (NASDAQ:AFFX) and Leica Biosystems announce the launch of Affymetrix' fully automated RNA in situ hybridization assays ViewRNATM eZ Assays on the Leica BOND RX staining platform.

8 May 2014

Protein expression predicts postop NSCLC recurrence, survival

US-based researchers have identified a panel of 12 proteins that may help predict overall survival and the risk of recurrence in patients treated with surgery for non-small-cell lung cancer.

15 Apr 2014

NSCLC gene fusion testing, targeted crizotinib – not yet cost effective

Genomic fusion testing for echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase genes plus targeted first-line crizotinib is not a cost effective treatment strategy for patients with advanced non-squamous non-small-cell lung cancer, shows a Canadian analysis.

20 Mar 2014

Genetic testing may help select women with ER+ breast cancer for extended hormone therapy

Genetic analyses of results from 1125 postmenopausal women being treated for oestrogen responsive breast cancer have shown that some of them are more likely than others to have a late recurrence of their cancer and might benefit from ten years of hormone therapy rather than five.

19 Mar 2014

Proteomics identifies possible RCC biomarkers

Proteomic analysis has identified significant differences between the proteins expressed in renal cell carcinoma samples and in healthy renal tissue, UK researchers report.

17 Mar 2014

3-D imaging of two different mouse models helps understand Apert Syndrome development

Three dimensional imaging of two different mouse models of Apert Syndrome shows that cranial deformation begins before birth and continues, worsening with time, according to a team of researchers who studied mice to better understand and treat the disorder in humans.

4 Mar 2014

Immunohistochemistry News and Research

Further Reading

ISO 13485:2003 certification for Advanced Cell Diagnostics

Study provides platform for detailed study of nerve injury and repair during Wallerian degeneration

ROS1 fusion genes found in young East Asian patients with lung adenocarcinoma

TAZ represents a novel therapeutic target in NSCLC

NANOG gene linked to tumours derived from stratified epithelia

Biomarkers help resolve differential diagnosis between MPM and non-cancerous pleural tissue

New investigational immunotherapy benefits people with advanced urothelial bladder cancer

New data highlights molecular profiling in guiding treatment of patients with gynecologic malignancies

CTR1 may be required for successful platinum-based therapy in NSCLC

NSHOA and Caris Life Sciences collaborate to establish personalized cancer care program

Leica and Affymetrix launch fully automated RNA in situ hybridization assays

Protein expression predicts postop NSCLC recurrence, survival

NSCLC gene fusion testing, targeted crizotinib – not yet cost effective

Genetic testing may help select women with ER+ breast cancer for extended hormone therapy

Proteomics identifies possible RCC biomarkers

3-D imaging of two different mouse models helps understand Apert Syndrome development

PerkinElmer launches Lamina slide scanner for clearer visualization of protein biomarker in tissue

New corneal layer important for intraocular pressure maintenance

Study: Routine testing with FISH and IHC may enhance detection of ALK-positive NSCLC

Researchers develop novel technique for detecting ALK rearrangements in non-small cell lung cancers

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Latest Life Science News