Inflammation News and Research

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Combination of two compounds found in red grapes, oranges could treat diseases

A combination of two compounds found in red grapes and oranges could be used to improve the health of people with diabetes, and reduce cases of obesity and heart disease.

12 May 2016

Human gut model HuMiX represents actual conditions, processes that occur within intestines

One of the most complex human organs is the digestive tract: Here, the body comes into contact with all manner of diet-derived compounds and with countless bacteria.

11 May 2016

University of Glasgow-led study could lead to improved treatments for lymphoma, other cancers

A study by scientists at the University of Glasgow, which reveals the critical role a common cancer-associated gene plays in lymphoma development, could lead to improved treatments for a range of cancers.

11 May 2016

EvOx Therapeutics raises £10m to target new therapeutic system for untreatable diseases

Oxford spinout EvOx Therapeutics will harness the body’s own precision communications system to deliver drugs to specific parts of the body, with the aim of treating conditions which are currently untreatable including those affecting the brain, as well as autoimmune diseases and cancers.

11 May 2016

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin system (RAS) that both prevents and reverses some characteristics of diabetic retinopathy in a mouse model.

10 May 2016

Caltech researchers discover new potential cause for Crohn's disease

The community of beneficial bacteria that live in our intestines, known as the gut microbiome, are important for the development and function of the immune system. There has been growing evidence that certain probiotics--therapies that introduce beneficial bacteria into the gut--may help alleviate some of the symptoms of intestinal disorders such as Crohn's disease.

10 May 2016

Research shows spleen MZ B cells produce signaling proteins involved in inflammatory responses

The inability to adequately respond to infection can cause a whole-body state of inflammation known as sepsis. This can eventually lead to systemic inflammatory response syndrome (SIRS), and even death.

9 May 2016

Researchers investigate effects of new steroid treatment on children with ARDS

Acute Respiratory Distress Syndrome (ARDS) affects hundreds of thousands of people each year, many of them children. Those with this life threatening condition have severely injured and wet lungs, and are treated with mechanical ventilation.

9 May 2016

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

A major type of inflammatory bowel disease (IBD) may be caused in part by genetic variants that prevent beneficial bacteria in the gut from doing their job, according to a new study published today in the journal Science.

6 May 2016

Cancerous lung tumors can alter metabolism by hijacking circadian mechanisms

University of California, Irvine scientists who study how circadian rhythms - our own body clocks - control liver function have discovered that cancerous lung tumors can hijack this process and profoundly alter metabolism.

6 May 2016

Studies show mango consumption may contribute to protective health effects

Four new studies surrounding the effects of mango consumption suggest this superfruit has the potential to help combat adverse effects associated with high fat diets and obesity (animal study), as well inhibit growth of fat cells (anti-lipogenic properties in an in-vivo study), slow advancement of breast cancer tumors (animal study), as well as improve regularity and decrease inflammation associated with constipation (human subject study).

6 May 2016

Development of atherosclerosis can increase osteoporosis risk

Patients with atherosclerosis—the buildup of cholesterol and fat in arteries—are at a higher risk of osteoporosis. A new study published in the American Journal of Physiology—Endocrinology and Metabolism shows how the development of atherosclerosis encourages the loss of bone density.

6 May 2016

Older adults become more sensitive to pain, study shows

When older relatives complain about their pains, show a little empathy, because new research suggests that as we age, we may all become more sensitive to pain. A small, preliminary University of Florida Health study has suggested for the first time that inflammation may occur more quickly and at a higher magnitude -- and stays around longer -- when older adults experience pain versus when younger adults experience pain.

5 May 2016

Study shows short-term statin treatment does not benefit heart surgery patients

Giving daily doses of statins for a few days before and after heart surgery does not prevent heart muscle damage or the development of atrial fibrillation (AF), according to an international clinical trial led by the University of Oxford and funded by the British Heart Foundation.

5 May 2016

Blueberry component PS may protect against dry eye disease

Pterostilbene (PS), a component of blueberries, have been found to protect against dry eye disease according to a new study.

5 May 2016

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. Results of the Phase II clinical trial will appear in the May 5 issue of the New England Journal of Medicine.

5 May 2016

Human milk hormones may play vital role in shaping healthy infant microbiome

A new University of Colorado Anschutz Medical Campus study finds that hormones in breast milk may impact the development of healthy bacteria in infants' guts, potentially protecting them from intestinal inflammation, obesity and other diseases later in life.

5 May 2016

Promising specialty medical home approach to patient-centered, cost-effective care for IBD patients

A specialty medical home--providing expert medical care coordinated with attention to social support and mental health--is a promising new approach to patient-centered, cost-effective care for patients with Crohn's disease and ulcerative colitis, according to a special "Future Directions" paper in the May issue of Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America. The journal is published by Wolters Kluwer.

5 May 2016

Study evaluates effects of corticosteroids along with anti-tuberculosis drugs in tuberculous meningitis

The Cochrane Infectious Diseases Group have carried out a review update to evaluate the effects of corticosteroids being used alongside anti-tuberculosis medication to treat people suffering from tuberculous meningitis.

4 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

Inflammation News and Research

Combination of two compounds found in red grapes, oranges could treat diseases

Human gut model HuMiX represents actual conditions, processes that occur within intestines

University of Glasgow-led study could lead to improved treatments for lymphoma, other cancers

EvOx Therapeutics raises £10m to target new therapeutic system for untreatable diseases

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Caltech researchers discover new potential cause for Crohn's disease

Research shows spleen MZ B cells produce signaling proteins involved in inflammatory responses

Researchers investigate effects of new steroid treatment on children with ARDS

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

Cancerous lung tumors can alter metabolism by hijacking circadian mechanisms

Studies show mango consumption may contribute to protective health effects

Development of atherosclerosis can increase osteoporosis risk

Older adults become more sensitive to pain, study shows

Study shows short-term statin treatment does not benefit heart surgery patients

Blueberry component PS may protect against dry eye disease

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Human milk hormones may play vital role in shaping healthy infant microbiome

Promising specialty medical home approach to patient-centered, cost-effective care for IBD patients

Study evaluates effects of corticosteroids along with anti-tuberculosis drugs in tuberculous meningitis

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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