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Innate Immunotherapeutics announces clinical trial fully enrolled and receives strong interest from potential Pharma partners

Innate Immunotherapeutics Limited has closed enrolment into the Company's Phase 2B placebo controlled efficacy trial of MIS416 in patients with secondary progressive multiple sclerosis (SPMS). The study has exceeded the original recruitment target of 90 subjects with the successful enrolment this week of the 93rd patient.

14 Apr 2016

Novel biochemical method can extend lifetime of implantable medical devices

Blood-contacting implantable medical devices, such as stents, heart valves, ventricular assist devices, and extracorporeal support systems, as well as vascular grafts and access catheters, are used worldwide to improve patients' lives. However, these devices are prone to failure due to the body's responses at the blood-material interface; clots can form and inflammatory reactions can prevent the device from performing as indicated. Currently, when this occurs, the only solution is to replace the device.

13 Apr 2016

Study finds link between low pollution levels and stronger lungs in California kids

A USC study that tracked Southern California children over a 20-year period has found they now have significantly fewer respiratory symptoms as a result of improved air quality.

13 Apr 2016

Scientists reveal mechanism involved in regulation of lymphangiogenesis

After an injury to tissues, such as in organ transplantation, the body grows new lymphatic vessels in a process known as lymphangiogenesis. A new study in Nature Communications reveals a mechanism involved in the regulation of this process, specifically in corneal transplants and infectious eye disease.

13 Apr 2016

Inserm study reveals potential of secondary system to improve heart function

Heart failure affects over one million people in France. Although the blood system is the first to have been explored for the purpose of improving heart function, a study by Inserm has revealed the potential of a secondary system that had previously received scant attention.

13 Apr 2016

Cell-signaling protein holds key to understanding autoantibody formation in lupus patients

A signaling molecule called interferon gamma could hold the key to understanding how harmful autoantibodies form in lupus patients. The finding could lead to new treatments for the chronic autoimmune disease, said researchers at Penn State College of Medicine.

12 Apr 2016

E-cigarette smoking has more deleterious short-term effects on pulmonary function in asthmatic smokers

E-cigarette smoking is increasingly promoted as a safer alternative to cigarette smoking, but a growing body of evidence points to its potential dangers. Adding to the evidence, researchers will report at CHEST World Congress this month on a study of e-cigarettes and the immediate effects on pulmonary function in healthy and mild asthmatic young smokers.

12 Apr 2016

Pooled analysis from seven clinical studies demonstrates consistent efficacy for ceftazidime-avibactam in the treatment of multi-drug resistant gram-negative bacteria

AstraZeneca has presented positive data demonstrating the efficacy of the investigational antibiotic, ceftazidime-avibactam (CAZ-AVI), in treating patients with ceftazidime-resistant Gram-negative infections, which are increasingly resistant to most available antibiotics, often precipitating the need for clinicians to reach for agents previously reserved for last-line use.

12 Apr 2016

Researchers identify vital inflammatory mechanisms in type 1 diabetes, obesity-related kidney dysfunction

In a new study, published in the online edition of the journal EBioMedicine, a multi-disciplinary team led by researchers at University of California, San Diego School of Medicine has identified key inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction.

11 Apr 2016

Researchers find evidence that protein involved in regulating inflammation has anti-septic effects

Sepsis represents a serious complication of infection and is one of the leading causes of death and critical illness worldwide due in part to the lack of effective therapies. A report in the American Journal of Pathology provides evidence from both mouse and human studies that SHARPIN, a protein involved in regulating inflammation, has anti-septic effects. These findings may spur development of novel sepsis treatments.

11 Apr 2016

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

New study backs up observations in Chronic Obstructive Pulmonary Disease (COPD) patients showing reduced effectiveness of symptom-reliever medication (β2-adrenoceptor agonists) in flare-ups linked to cigarette smoking and infection with viruses such as influenza.

11 Apr 2016

Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Cardiovascular disease from atherosclerosis is one of the most common causes of death worldwide. Inflammation plays a crucial role in atherosclerosis and cholesterol crystals are considered to be early triggers in the development of the disease.

11 Apr 2016

Antimicrobial silicon nitride holds promise as therapeutic aid for treating periodontitis

Severe gum disease known as periodontitis can lead to tooth loss, and treating it remains a challenge. But new approaches involving silicon nitride, a ceramic material used in spinal implants, could be on the way. The surface of silicon nitride has a lethal effect on the bacteria that commonly cause periodontitis. Now scientists, reporting in ACS' journal Langmuir, are examining why this happens. Their findings could help inform future efforts to treat the disease.

7 Apr 2016

New extended-release pills could reduce dosage frequency of some drugs

Researchers from MIT and Brigham and Women's Hospital have designed a new type of pill that, once swallowed, can attach to the lining of the gastrointestinal tract and slowly release its contents. The tablet is engineered so that one side adheres to tissue, while the other repels food and liquids that would otherwise pull it away from the attachment site.

7 Apr 2016

Salk scientists identify specific cellular switches that clear dying, dead neurons

By adolescence, your brain already contains most of the neurons that you'll have for the rest of your life. But a few regions continue to grow new nerve cells--and require the services of cellular sentinels, specialized immune cells that keep the brain safe by getting rid of dead or dysfunctional cells.

7 Apr 2016

Person's age, mobility could be powerful predictors of survival than certain biomarkers

Advances in technology allow scientists to measure intricate details about the human body that greatly enhance understanding of health, disease and aging.

7 Apr 2016

Carbohydrate-binding protein controls inflammation in osteoarthritis patients

More and more people, particularly older people, are suffering from osteoarthritis due to wear and tear on their joints. This primarily affects the knee and hip joints but also the spine. In earlier studies, scientists at MedUni Vienna Department of Orthopaedics showed that raised levels of certain proteins, so-called galectins, and their docking sites are found in patients with osteoarthritis.

7 Apr 2016

Wake Forest Baptist researchers looking for ways to keep older adults on their feet

There's no getting around it: Simply getting around is a major issue for older adults. "People are in nursing homes for two reasons, either they can't think or they can't walk," said Stephen Kritchevsky, Ph.D., director of the Sticht Center on Aging at Wake Forest Baptist Medical Center. North Carolina. "We're working very hard on the thinking part, and the walking part is equally important.

6 Apr 2016

Researchers identify possible genetic basis for coronary artery disease

For many people, coronary artery disease, or CAD—the buildup of plaque in the heart's arteries—is an unfortunate part of aging. By studying the genetic makeup of those who manage to maintain clear arteries into old age, researchers have identified a possible genetic basis for the disease, as well as potential new opportunities to prevent it.

6 Apr 2016

Komodo Technologies releases AIO Smart Sleeve and AIO M.D. for monitoring heart conditions

Komodo Technologies, Inc. today announces the first compression sleeves available to consumers that allow for activity tracking and heart monitoring.

6 Apr 2016

Inflammation News and Research

Innate Immunotherapeutics announces clinical trial fully enrolled and receives strong interest from potential Pharma partners

Novel biochemical method can extend lifetime of implantable medical devices

Study finds link between low pollution levels and stronger lungs in California kids

Scientists reveal mechanism involved in regulation of lymphangiogenesis

Inserm study reveals potential of secondary system to improve heart function

Cell-signaling protein holds key to understanding autoantibody formation in lupus patients

E-cigarette smoking has more deleterious short-term effects on pulmonary function in asthmatic smokers

Pooled analysis from seven clinical studies demonstrates consistent efficacy for ceftazidime-avibactam in the treatment of multi-drug resistant gram-negative bacteria

Researchers identify vital inflammatory mechanisms in type 1 diabetes, obesity-related kidney dysfunction

Researchers find evidence that protein involved in regulating inflammation has anti-septic effects

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Antimicrobial silicon nitride holds promise as therapeutic aid for treating periodontitis

New extended-release pills could reduce dosage frequency of some drugs

Salk scientists identify specific cellular switches that clear dying, dead neurons

Person's age, mobility could be powerful predictors of survival than certain biomarkers

Carbohydrate-binding protein controls inflammation in osteoarthritis patients

Wake Forest Baptist researchers looking for ways to keep older adults on their feet

Researchers identify possible genetic basis for coronary artery disease

Komodo Technologies releases AIO Smart Sleeve and AIO M.D. for monitoring heart conditions

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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