Inflammation News and Research

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Subset of TH17 cells linked to inflammation in Crohn’s disease patients, find TSRI scientists

Two-thirds to three-quarters of the estimated 700,000 Americans living with Crohn’s disease, an autoimmune condition that can disrupt the entire gastrointestinal tract, will require surgery at some point during their life. Patients and physicians often turn to this surgical intervention after a patient develops resistance to current treatments, such as steroids.

9 Jan 2014

TSRI scientists identify small subset of immune cells that play major role in development of Crohn's disease

Two-thirds to three-quarters of the estimated 700,000 Americans living with Crohn's disease, an autoimmune condition that can disrupt the entire gastrointestinal tract, will require surgery at some point during their life.

9 Jan 2014

Norwegian researchers map genetic variations associated with increased risk of MS and MG

The Norwegian researchers have taken part in an international cooperative effort to map 110 genetic variations that increase the risk of MS and MG. Most of these genetic variations have been mapped in recent years.

9 Jan 2014

NYSCF and ISMMS scientists successfully generate stem cell model of familial Alzheimer's disease

Scientists at The New York Stem Cell Foundation Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai successfully generated a stem cell model of familial Alzheimer's disease.

8 Jan 2014

Apitope-led consortium awarded FP7 Health Innovation funding to develop Graves' disease vaccine

Apitope, the drug discovery and development company focused on treating the underlying cause of autoimmune diseases, today announces that the consortium, led by Apitope, which includes GSK Vaccines, Quintiles and KWS Biotest Limited, has been awarded prestigious Framework Programme 7 Health Innovation funding by the European Commission to develop its Graves' disease therapeutic vaccine, including a Phase I first-in-man study in Graves' disease patients.

8 Jan 2014

AP-1 proteins modulate fat accumulation in liver, say researchers

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease.

8 Jan 2014

Synthetic cannabinoid molecule created for osteoarthritis

Chemical compounds synthesised in the laboratory, similar to those found in cannabis, could be developed as potential drugs to reduce the pain of osteoarthritis.

7 Jan 2014

Kindergarten teacher diagnosed with rare neurological syndrome

The journal Neurology is reporting an unusual and heart-rending case of a reading teacher who suddenly lost her ability to read.

6 Jan 2014

Adherence to nutrition recommendations is weak among people with metabolic syndrome

Adherence to dietary recommendations is weak among people suffering from metabolic syndrome or having increased risk for metabolic syndrome, according to the Nordic SYSDIET study led by the University of Eastern Finland.

6 Jan 2014

AstraZeneca to take over Probiodrug's CDK9 inhibitor program

Probiodrug AG announced today the transfer of its experimental cyclin-dependent kinase 9 inhibitor program to AstraZeneca. The transaction includes the sale to AstraZeneca of a lead molecule and back-up compounds with the associated intellectual property. CDK9, which has been implicated in the transcriptional regulation of genes involved in proliferation and inflammation, is a promising target for the treatment of both cancer and inflammatory diseases.

3 Jan 2014

Novel technique helps people with word blindness to read again

In the journal Neurology, researchers report a novel technique that enables a patient with "word blindness" to read again.

3 Jan 2014

Study indicates that smoking disrupts circadian clock function in both lungs and brain

As if cancer, heart disease and other diseases were not enough motivation to make quitting smoking your New Year's resolution, here's another wake-up call: New research published in the January 2014 issue of The FASEB Journal suggests that smoking disrupts the circadian clock function in both the lungs and the brain.

3 Jan 2014

Macrophages invade diabetic pancreatic tissue during early stages of type 2 diabetes

As people's waistlines increase, so does the incidence of type 2 diabetes. Now scientists have a better understanding of exactly what happens in the body that leads up to type 2 diabetes, and what likely causes some of the complications related to the disease. Specifically, scientists from Denmark have found that in mice, macrophages, a specific type of immune cell, invade the diabetic pancreatic tissue during the early stages of the disease.

2 Jan 2014

FDA, USDA approve SALMONELEX as GRAS food processing aid against Salmonella

FDA & USDA announced today they have approved SALMONELEX as a "GRAS" (Generally Recognized as Safe) food processing aid against Salmonella. The new product consists of natural phages against Salmonella and is produced by Micreos of The Netherlands. The company confirms that industrial scale projects with US poultry processors will start in January 2014.

31 Dec 2013

Penn researchers receive PCORI awards to develop, expand health data network for patients, researchers

Two teams led by researchers in the Perelman School of Medicine at the University of Pennsylvania have been approved for funding awards by the Patient-Centered Outcomes Research Institute (PCORI).

31 Dec 2013

MitoQ antioxidant reverses MS-like disease in animal

Researchers at Oregon Health & Science University have discovered that an antioxidant designed more than a dozen years ago to fight damage within human cells significantly helps symptoms in mice that have a multiple sclerosis-like disease.

27 Dec 2013

A valuable guide for diabetic patients

McCord Research, Inc., founded by Darlene McCord, Ph.D., FAPWCA, has produced a valuable guide to help people with diabetes take care of their feet for a lifetime. Dr. McCord has over 30 years of experience in the skin and wound care industry. Ten years ago she also created the most successful skin and wound care product line in North America.

27 Dec 2013

THRIL could be novel biomarker for immune activation, potential target for inflammatory diseases

Sanford-Burnham Medical Research Institute scientists have discovered a new molecule that forms when certain white blood cells-macrophages-are stimulated in response to pathogens.

27 Dec 2013

Transient receptor potential channel A1 causes calcitonin gene-related peptide release in neurons

Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents, which may contribute to generation of neurogenic inflammation and hyperalgesia.

26 Dec 2013

Genetics of rheumatoid arthritis contributes to biology and drug discovery

The results of the largest international study to date into the genetic basis of rheumatoid arthritis shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis.

26 Dec 2013

Inflammation News and Research

Subset of TH17 cells linked to inflammation in Crohn’s disease patients, find TSRI scientists

TSRI scientists identify small subset of immune cells that play major role in development of Crohn's disease

Norwegian researchers map genetic variations associated with increased risk of MS and MG

NYSCF and ISMMS scientists successfully generate stem cell model of familial Alzheimer's disease

Apitope-led consortium awarded FP7 Health Innovation funding to develop Graves' disease vaccine

AP-1 proteins modulate fat accumulation in liver, say researchers

Synthetic cannabinoid molecule created for osteoarthritis

Kindergarten teacher diagnosed with rare neurological syndrome

Adherence to nutrition recommendations is weak among people with metabolic syndrome

AstraZeneca to take over Probiodrug's CDK9 inhibitor program

Novel technique helps people with word blindness to read again

Study indicates that smoking disrupts circadian clock function in both lungs and brain

Macrophages invade diabetic pancreatic tissue during early stages of type 2 diabetes

FDA, USDA approve SALMONELEX as GRAS food processing aid against Salmonella

Penn researchers receive PCORI awards to develop, expand health data network for patients, researchers

MitoQ antioxidant reverses MS-like disease in animal

A valuable guide for diabetic patients

THRIL could be novel biomarker for immune activation, potential target for inflammatory diseases

Transient receptor potential channel A1 causes calcitonin gene-related peptide release in neurons

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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