Inflammation News and Research

RSS

SignaBlok's novel peptide inhibitor of TREM-1 suppresses cancer progression

SignaBlok, Inc., a Massachusetts-based biopharmaceutical company, today announced the successful in vivo proof of concept data that demonstrate that the company's novel mechanism-based, first-in-class peptide inhibitor of TREM-1 effectively suppresses cancer progression in mouse models of lung cancer and dramatically improves survival in septic mice.

18 Sep 2013

RedHill Biopharma to initiate phase III trial of RHB 104 in Crohn's disease patients

UCF College of Medicine professor Dr. Saleh Naser soon will participate in a clinical trial to test whether a new antibiotic therapy acquired by RedHill Biopharma can be used to treat Crohn's disease patients.

18 Sep 2013

VBP15 drug shows early promise for treatment of Duchenne muscular dystrophy

A preclinical study led by researchers at Children's National Medical Center has found that a new oral drug shows early promise for the treatment of Duchenne muscular dystrophy.

18 Sep 2013

Researchers discover how Yersinia immobilizes immune system to spread within organs

Researchers at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have identified how one type of bacteria, Yersinia, immobilizes the immune system in order to grow in the organs of mice. To do so, the researchers extended the use of a technique and suggest that it could be used to study other bacteria that use the same or similar means of infection.

17 Sep 2013

NIEHS grant renewal opens next chapter in 18-year research effort into brain injury biomarker

The National Institute of Environmental Health Sciences (NIEHS) has awarded a five-year, $1.5 million grant extension to Columbia University's Mailman School of Public Health to fund research into the function of a biomarker for brain injury called Translocator Protein 18 kDa, better known as TSPO, in order to better understand its function in brain injury and inflammation and discover targets for therapy.

17 Sep 2013

Researchers develop new variety of corked microbottle for drugs

Sustained-release formulations that release drugs over longer periods of time are not the final step in the evolution of “intelligent” drug delivery systems. Modern pharmaceuticals are being designed to be released only in a specific, diseased organ; on cues from our circadian rhythm; or under specific physiological conditions.

17 Sep 2013

Understanding essential role of gut microbes in immune system

A new understanding of the essential role of gut microbes in the immune system may hold the key to dealing with some of the more significant health problems facing people in the world today, Oregon State University researchers say in a new analysis.

17 Sep 2013

Researchers identify gene mutation linked to age-related macular degeneration

An international team of researchers, led by scientists at The Genome Institute at Washington University School of Medicine in St. Louis and the University of Michigan School of Public Health in Ann Arbor, has identified a gene mutation linked to age-related macular degeneration (AMD), the leading cause of blindness in Americans over age 50.

17 Sep 2013

Gene variations predict breast cancer sleep disturbance

Researchers have identified cytokine gene variations in women with breast cancer that may help to identify those at increased risk for sleep disturbance following surgery.

16 Sep 2013

Flights are major risk factors for bouts of inflammation in IBD patients

Patients with a chronic intestinal inflammation often experience bouts of inflammation after a journey. The main cause of this is not the stress of travelling, but the lack of oxygen experienced in an aircraft or during high altitude stays in the mountains.

16 Sep 2013

LifeSensors receives U.S. patent for development of novel DUB substrates

LifeSensors, Inc., a biotech company developing cutting-edge technologies for studying the ubiquitin pathway, has been awarded a U.S. patent for the development of novel, fluorescent di- and poly-ubiquitin deubiquitinase substrates (US 8,518,660).

16 Sep 2013

Study evaluates effectiveness of new meningitis serogroup A vaccine in sub-Saharan Africa

Evaluation of the effectiveness of a mass vaccination campaign with a new meningitis serogroup A vaccine, PsA-TT, in sub-Saharan Africa found that it had a dramatic impact on cases of serogroup meningitis and on carriage of the disease-causing bacteria in the throat, according to new research published in The Lancet.

13 Sep 2013

Scottsdale Healthcare, TGen initiate Thunder God vine clinical trial in pancreatic cancer patients

Taking a page from Chinese herbal medicine, Scottsdale Healthcare and the Translational Genomics Research Institute today initiated the first-in-human clinical trial for pancreatic cancer patients using a compound derived from a plant known as "Thunder God vine."

13 Sep 2013

Scientists uncover how bacterium responsible for periodontal disease worsens RA

Does gum disease indicate future joint problems? Although researchers and clinicians have long known about an association between two prevalent chronic inflammatory diseases - periodontal disease and rheumatoid arthritis - the microbiological mechanisms have remained unclear.

13 Sep 2013

Proper precautions may help people with allergies enjoy the beautiful fall weather

As summer comes to a close, kids head back to school and preparation for fall begins, don't' forget to consider fall allergies. An estimated 35 million Americans suffer from allergies, which in the fall begin in late August and peak in September. For those with fall allergies, three triggers typically occur - ragweed, indoor allergens and infections.

12 Sep 2013

Astragaloside IV contributes to sciatic nerve regeneration

Astragaloside IV, the main component of the traditional Chinese medicine astragalus membra-naceus, has been shown to inhibit inflammation, oxidation, and apoptosis, and exerts immu-noregulatory effects. Xiaohong Zhang and colleagues from School of Pharmacutical Sciences, Jilin University investigated whether astragaloside IV could promote the repair of injured sciatic nerve.

12 Sep 2013

Study: Atorvastatin reduces inflammation, thrombogenesis in patients with acute ischemic stroke

The population of northeastern China has a high incidence of ischemic stroke. Previous studies have shown that intracranial large-artery atherosclerosis is one of the main causes of ischemic stroke, and that the mechanisms are related to inflammation and thrombosis of the affected arteries.

12 Sep 2013

Study shows fat transplantation may treat inherited metabolic diseases

Transplanting fat may treat such inherited metabolic diseases as maple syrup urine disease (MSUD) by helping the body process the essential amino acids that these patients cannot, according to Penn State College of Medicine researchers.

12 Sep 2013

Astrazeneca Licenses Merck's Cancer Candidate MK-1775

...

11 Sep 2013

Improved lung function in patients with moderate asthma severity observed with investigational Tiotropium

Boehringer Ingelheim will present a pooled analysis of new data from the Phase 3 UniTinA-asthma® program at the European Respiratory Society (ERS) Annual Congress 2013 in Barcelona. The data from the individual MezzoTinA-asthma® Phase 3 studies (NCT01340209 and NCT00565266), from which the pooled data are derived, show the addition of tiotropium delivered via the Respimat® inhaler to medium-dose maintenance inhaled corticosteroid (ICS) therapy (defined as 400-800 µg budesonide/day or equivalent) improved lung function and provided sustained bronchodilation over 24 hours in patients with moderate asthma and airflow limitation. Tiotropium is being investigated to determine the medicine’s efficacy in treating asthma patients and is not currently approved for this indication.

11 Sep 2013

Inflammation News and Research

SignaBlok's novel peptide inhibitor of TREM-1 suppresses cancer progression

RedHill Biopharma to initiate phase III trial of RHB 104 in Crohn's disease patients

VBP15 drug shows early promise for treatment of Duchenne muscular dystrophy

Researchers discover how Yersinia immobilizes immune system to spread within organs

NIEHS grant renewal opens next chapter in 18-year research effort into brain injury biomarker

Researchers develop new variety of corked microbottle for drugs

Understanding essential role of gut microbes in immune system

Researchers identify gene mutation linked to age-related macular degeneration

Gene variations predict breast cancer sleep disturbance

Flights are major risk factors for bouts of inflammation in IBD patients

LifeSensors receives U.S. patent for development of novel DUB substrates

Study evaluates effectiveness of new meningitis serogroup A vaccine in sub-Saharan Africa

Scottsdale Healthcare, TGen initiate Thunder God vine clinical trial in pancreatic cancer patients

Scientists uncover how bacterium responsible for periodontal disease worsens RA

Proper precautions may help people with allergies enjoy the beautiful fall weather

Astragaloside IV contributes to sciatic nerve regeneration

Study: Atorvastatin reduces inflammation, thrombogenesis in patients with acute ischemic stroke

Study shows fat transplantation may treat inherited metabolic diseases

Astrazeneca Licenses Merck's Cancer Candidate MK-1775

Improved lung function in patients with moderate asthma severity observed with investigational Tiotropium

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News