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Fibrin key to protection during gram-negative sepsis

New research from the Trudeau Institute may help to explain why anticoagulant therapies have largely failed to extend the lives of patients with sepsis. The study was led by Deyan Luo, a postdoctoral fellow in Stephen Smiley's laboratory. It shows that fibrin, a key product of the blood clotting process, is critical for host defense against Yersinia enterocolitica, a gram-negative bacterium that causes sepsis in humans and experimental mice.

11 Jul 2011

New corticosteroid with cream-like base

Upsher-Smith Laboratories, Inc. announced the launch of Trianex 0.05% (Triamcinolone Acetonide Ointment), a prescription topical corticosteroid offering the feel of a cream with the strength of an ointment.

11 Jul 2011

Study describes how obesity could protect against mortality in patients with RI/ARDS

Researchers have discovered that obese adults undergoing surgery are less frequently developing respiratory insufficiency (RI) and adult respiratory distress syndrome (ARDS), and that when they do, they are less likely to have fatal outcomes.

11 Jul 2011

MicroOCT technology can reveal cellular features of coronary artery disease

Researchers at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) have developed a one-micrometer-resolution version of the intravascular imaging technology optical coherence tomography (OCT) that can reveal cellular and subcellular features of coronary artery disease.

11 Jul 2011

New genetic clues about ankylosing spondylitis

A study involving over 5,000 people living with the joint disorder ankylosing spondylitis has identified a series of genetic variants associated with increased susceptibility to the condition as well as providing new clues to how the condition may be treated in the future.

11 Jul 2011

InVivo files biopolymer scaffold IDE with FDA to initiate spinal cord injury clinical trial

InVivo Therapeutics today announced that the Company has submitted an Investigational Device Exemption (IDE) to the U.S. Food and Drug Administration (FDA) for a proprietary biopolymer scaffolding device to protect and support spinal tissue and prevent secondary injury, including inflammation and glial scarring, following traumatic spinal cord injury.

8 Jul 2011

Gum disease linked to infertility

According to experts gum disease may reduce the chances of getting pregnant. Poor oral health is as bad for fertility as obesity - delaying conception by about two months says latest research.

7 Jul 2011

Solution for treating obesity-related diseases may reside in fat tissue

Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have shown that the quality – not just the quantity – of adipose, or fat, tissue is a significant contributing factor in the development of inflammation and vascular disease in obese individuals. The study, which is a special feature on the iPAD version of the Journal of the American College of Cardiology, provides compelling evidence that the answer to treating cardiovascular disease and other obesity-related disorders, such as type 2 diabetes and cancer, might be found in the adipose tissue itself.

7 Jul 2011

Levels of urinary eosinophil protein-X may predict future atopy in asymptomatic children

The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X (u-EPX), a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years.

7 Jul 2011

Specialist RM clinic helps women achieve subsequent live birth

The researchers studied the records of 987 women with a minimum of three consecutive miscarriages, who had been referred to a specialist RM clinic between 1986 and 2008.

6 Jul 2011

Periodontal disease can affect woman's chance of conceiving

Professor Roger Hart told the annual meeting of the European Society of Human Reproduction and Embryology that the negative effect of gum disease on conception was of the same order of magnitude as the effect of obesity.

5 Jul 2011

Prolonged exposure to air pollution can have visible, negative effects on brain

Long-term exposure to air pollution can lead to physical changes in the brain, as well as learning and memory problems and even depression, new research in mice suggests.

5 Jul 2011

Adipose tissue might serve as target for treating obesity-related disorders

Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have shown that the quality - not just the quantity - of adipose, or fat, tissue is a significant contributing factor in the development of inflammation and vascular disease in obese individuals.

5 Jul 2011

Anti-inflammatory drugs may increase risk of atrial fibrillation

Commonly used painkillers to treat inflammation are linked to an increased risk of irregular heart rhythm, concludes a study published on bmj.com today.

5 Jul 2011

'Genotype positive' individuals susceptible to increased periodontal tissue destruction after dental implants

The health of the surrounding tissue affects the success of a dental implant. Identifying and reducing risk factors is therefore a key step in the implant process. Now a combination of genes has been identified as a possible indicator of greater tissue destruction leading to negative outcomes for implants.

1 Jul 2011

Six new scientists to receive SWCRF grants for cancer research

This year, the Samuel Waxman Cancer Research Foundation awarded individual grants to six new researchers in addition to funding 18 collaborative grants and three ongoing individual grants. The Foundation expanded its scientific grants program to a total of more than $3.1 million.

1 Jul 2011

Surgical complications much more likely in obese patients

Obese patients are nearly 12 times more likely to suffer a complication following elective plastic surgery than their normal-weight counterparts, according to new research by Johns Hopkins scientists.

30 Jun 2011

Serum-free media with growth factors can improve MSCs' cell fate regulation

Mensenchymal stem cells (MSCs), multipotent cells identified in bone marrow and other tissues, have been shown to be therapeutically effective in the immunosuppression of T-cells, the regeneration of blood vessels, assisting in skin wound healing, and suppressing chronic airway inflammation in some asthma cases.

30 Jun 2011

Early life adversity and prior depressive episodes make people become depressed more easily

We all know people who are able to roll with life's punches, while for others, every misfortune is a jab straight to the gut. Research examining this issue has found that although most people require significant adversity to become depressed - the death of a loved one, say, or getting fired - roughly 30 percent of people with first-time depression and 60 percent of people with a history of depression develop the disorder following relatively minor misfortunes.

30 Jun 2011