Inflammation News and Research

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Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

Cancer Research Technology Limited has announced that AstraZeneca has licensed exclusive worldwide rights to a patent family relating to a nuclear receptor/co-activator binding motif.

1 Dec 2004

African Americans more likely to carry genetic variants known to stimulate inflammatory response

Specific variants in genes that encode proteins regulating inflammation may hold a key to explaining a host of disease processes known to cause increased risk of illness and death among African Americans, according to a study from the University of Pittsburgh's Graduate School of Public Health (GSPH).

1 Dec 2004

Health risks of goat milk and derived products with regards to BSE/TSE

The Scientific Expert Working Group on BSE/TSE of the European Food Safety Authority’s (EFSA) Scientific Panel on Biological Hazards have published a statement on the safety of goat milk and milk products with regards to possible BSE/TSE risks.

29 Nov 2004

Study finds that stomach cancer originates from bone marrow derived stem cells, rather than from stomach stem cells

A common assumption among cancer specialists is that most cancers originate from tissue stem cells – for example, the gastric stem cells contained in the lining of the stomach.

29 Nov 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

FDA approval of Tysabri, for the treatment of multiple sclerosis

Biogen and Elan Corporation have announced that the U.S. Food and Drug Administration (FDA) has approved Tysabri (natalizumab), as treatment for relapsing forms of multiple sclerosis (MS) to reduce the frequency of clinical relapses.

24 Nov 2004

Experimental compound prevents cholesterol gallstone disease

A promising experimental compound prevents cholesterol gallstone disease in mice by stimulating the biochemical pathway that controls bile acid secretion by the liver, according to new studies by Howard Hughes Medical Institute researchers.

23 Nov 2004

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCÈ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity.

19 Nov 2004

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

19 Nov 2004

Vaccinex and Biocon to co-develop at least four therapeutic antibody products

The collaboration combines Vaccinex's unique capabilities to discover fully human monoclonal antibodies using its proprietary antibody discovery technology and Biocon's proven expertise in clinical research and biologics manufacturing.

19 Nov 2004

Nearly two-thirds of smokers are not concerned about developing Chronic Obstructive Pulmonary Disease

Nearly two-thirds (64 percent) of smokers are not concerned about developing Chronic Obstructive Pulmonary Disease (COPD), America’s fourth ranking cause of death even though more than half of them (55 percent) experience at least one of the symptoms of COPD a minimum of once a week.

18 Nov 2004

Not all congestion-producing chronic rhinosinusitis infections are the same

Rather, this problem that afflicts some 30 million Americans annually has four severity classifications that could help guide treatment today and help find better treatments in the future, says the lead author on the study published in the November issue of The Laryngoscope.

18 Nov 2004

Early infection in low-birth-weight infants linked with poor neurodevelopmental

Extremely low-birth-weight (ELBW) infants who have an infection during their hospitalization following birth are more likely to have adverse neurodevelopmental outcomes than those infants who do not have an infection, according to a study in the November 17 issue of JAMA.

17 Nov 2004

Gene protects against environmental pollutants and pulmonary emphysema

Researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions have identified a “master gene” in mice that controls the action of 50 other genes whose products protect the lungs against environmental pollutants.

17 Nov 2004

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Remember when Grandma used to say, "don’t go out in the cold; you’ll get sick”? It turns out that she was right for a small number of people who have a condition called familial cold autoinflammatory syndrome (FCAS)

16 Nov 2004

Concord grapes increase good cholesterol

Drinking Concord grape juice significantly increased HDL--the good cholesterol--and significantly lowered two markers of inflammation in people with stable coronary artery disease, according to results of a study presented in the November issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology.

16 Nov 2004

Keeping fit lowers C-Reactive protein in people with metabolic syndrome

In people with signs of metabolic syndrome, including high blood pressure, high triglycerides, high cholesterol, elevated blood glucose and obesity, physical activity appears to reduce a marker for inflammation which has been linked to heart disease

16 Nov 2004

Fluorescent protein tool may speed identification of molecular changes that reveal cells' inner workings

Scientists at Johns Hopkins and the University of Texas Medical Branch have created a new tool that easily reveals when and where a key cellular signal is active.

16 Nov 2004

Brain inflammation is a sign of autism

A new study by scientists at Johns Hopkins shows that brain inflammation is a sign of autism. The findings are reported in the online edition of Annals of Neurology, the scientific journal of the American Neurological Association.

15 Nov 2004

Sirolimus drug-coated stent causes less inflammation than bare metal stents

In the treatment of coronary artery disease, a sirolimus drug-coated stent causes less inflammation than bare metal stents, according to preliminary research presented at the American Heart Association annual meeting by Loyola University Health System, Maywood, Ill.

11 Nov 2004

Inflammation News and Research

Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

African Americans more likely to carry genetic variants known to stimulate inflammatory response

Health risks of goat milk and derived products with regards to BSE/TSE

Study finds that stomach cancer originates from bone marrow derived stem cells, rather than from stomach stem cells

New research may lead to treatments for atherosclerosis

FDA approval of Tysabri, for the treatment of multiple sclerosis

Experimental compound prevents cholesterol gallstone disease

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Vaccinex and Biocon to co-develop at least four therapeutic antibody products

Nearly two-thirds of smokers are not concerned about developing Chronic Obstructive Pulmonary Disease

Not all congestion-producing chronic rhinosinusitis infections are the same

Early infection in low-birth-weight infants linked with poor neurodevelopmental

Gene protects against environmental pollutants and pulmonary emphysema

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Concord grapes increase good cholesterol

Keeping fit lowers C-Reactive protein in people with metabolic syndrome

Fluorescent protein tool may speed identification of molecular changes that reveal cells' inner workings

Brain inflammation is a sign of autism

Sirolimus drug-coated stent causes less inflammation than bare metal stents

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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