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Normalizing tumor vessels to improve chemotherapy drug delivery

Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal-"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at Children's Hospital Boston.

25 Aug 2008

Study reveals how blood flow force protects against atherosclerosis

Machines on cell surfaces, mechanical and lifeless as bed springs, protect blood vessels by responding to blood flow force, according to research published today in the Journal of Cell Biology. By sensing and reacting to force, such machines interfere with inflammatory pathways central to atherosclerosis, the cause of clogged arteries that lead to heart attack and stroke, the authors said. The next set of studies, already underway, seeks to "tweak" the process with the goal of designing a new class of therapies.

25 Aug 2008

Scientists uncover molecule that keeps pathogens like salmonella in check

Scientists at UT Southwestern Medical Center have found a potential new way to stop the bacteria that cause gastroenteritis, tularemia and severe diarrhea from making people sick.

21 Aug 2008

Eli Lilly acquires SGX Pharmaceuticals

Eli Lilly and Company has announced that it has completed the acquisition of SGX Pharmaceuticals, Inc. (Public, NASDAQ:SGXP), a San Diego-based biotechnology company focused on drug discovery and development in the area of oncology.

20 Aug 2008

Australian researchers reveal how cancers become more aggressive

A team of Australian scientists have discovered how some cancers are able to mutate into more aggressive and potentially fatal cancers in the human body.

11 Aug 2008

Scientists identify microRNA that controls blood vessel development - therapeutic target for a number of diseases

Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.

11 Aug 2008

Cancer survival secrets discovered by Australian researchers

A team of Monash University researchers has uncovered the role of a family of enzymes in the mutation of benign or less aggressive tumours into more aggressive, potentially fatal, cancers in the human body.

11 Aug 2008

Discovery of vital key to cancer

University of Manchester scientists have uncovered the 3D structure of Mps1 - a protein that regulates the number of chromosomes during cell division and thus has an essential role in the prevention of cancer - which will lead to the design of safer and more effective therapies.

From The University of Manchester 6 Aug 2008

Researchers discover novel kind of learning gene

Scientists at the Freie Universität Berlin have come one step closer to unraveling the molecular basis of learning. A team led by neurobiologist Bjorn Brembs has discovered the first gene for operant conditioning in the fruit fly Drosophila.

3 Aug 2008

Could new molecules - polyoxometalates - help treat cancer?

A fruitful collaboration between chemists and biologists has made it possible to identify the effects of a new class of molecules, polyoxometalates, primarily composed of metals and oxygen.

27 Jul 2008

Researcher develops method for early detection of leukemia relapse

Researchers at the Fred Hutchinson Cancer Research Center have developed a method that allows for the early detection of a common mechanism of resistance on drug treatment for chronic myeloid leukemia.

10 Jul 2008

Circulating tumor cells can reveal genetic signature of dangerous lung cancers

Using a miniature laboratory-on-a-chip device, a team of investigators at the Massachusetts General Hospital, led by Daniel Haber, M.D., Ph.D., and Mehmet Toner, Ph.D., both members of the MIT-Harvard Center for Cancer Nanotechnology Excellence (CCNE), has developed a method that detects and analyzes the genetic signature of rare tumor cells in the bloodstream.

9 Jul 2008

Eli Lilly to buy SGX Pharmaceuticals

Eli Lilly and Company and SGX Pharmaceuticals, Inc. today announced that the companies have signed a definitive merger agreement providing for the acquisition of SGX in an all-cash transaction. SGX, based in San Diego, California, is a biotechnology company focused on drug discovery and development in the area of oncology.

8 Jul 2008

Natural substance Argyrin shows promise for new cancer therapies

The effective treatment of many forms of cancer continues to pose a major problem for medicine. Many tumours fail to respond to standard forms of chemotherapy or become resistant to the medication.

8 Jul 2008

Funding boost in fight against leukaemia

University of Manchester researchers have been awarded £1.6 million to study a group of genes identified as playing a key role in leukaemia.

From The University of Manchester 3 Jul 2008

Carbohydrate and caffeine following exhaustive exercise helps muscles refuel

Recipe to recover more quickly from exercise: Finish workout, eat pasta, and wash down with five or six cups of strong coffee.

1 Jul 2008

Dividing cells find their middle by following a protein contour map

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It's also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individual proteins locate the center of their cell without direction from a 'master organizer,' is key to ensuring accurate division during mitosis.

30 Jun 2008

New discovery could lead to new treatments for Alzheimer's

Rutgers researcher Karl Herrup and colleagues at Case Western Reserve University have discovered that a protein that suppresses cell division in brain cells effectively "puts the brakes" on the dementia that comes with Alzheimer's disease (AD). When the brakes fail, dementia results.

24 Jun 2008

MicroRNA play a significant role in some human cancers

A new study demonstrates that microRNAs can modulate the expression of well known tumor-specific oncogenic translocation proteins and may play a significant role in some human cancers. The research, published by Cell Press in the June issue of the journal Cancer Cell, is likely to lead to new strategies for treating some specific lymphomas and leukemias.

9 Jun 2008

Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature

Researchers have demonstrated the possibility of preventing the human malaria parasite, Plasmodium falciparum, which is responsible for more than a million malaria deaths a year, from becoming sexually mature.

5 Jun 2008