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Australian researchers determine structure of JAK2 kinase, huge implications for development of new cancer drugs

Researchers from Monash's Department of Biochemistry and Molecular Biology have determined the structure of the protein JAK2 kinase, a discovery with huge implications for the design and development of new cancer drugs.

25 Oct 2005

Scientists gain better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases

UCSD researchers stretched cells in a workout chamber the size of a credit card to gain a better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases.

24 Oct 2005

Study identifies molecular switch that integrates cell survival signals from multiple intracellular signaling pathways

The finding has substantial clinical significance, as mutations in these cell survival-signaling pathways are associated with many human cancers, and a better understanding of how these pathways converge to regulate the delicate balance between cell proliferation and cell death may lead to development of more effective cancer therapies.

17 Oct 2005

GRK5 protein plays important role in hypertension

Researchers at Jefferson Medical College have implicated a protein called GRK5 as having an important role behind essential hypertension, which affects more than 65 million Americans.

5 Oct 2005

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

The first close-up look at a pro-inflammatory signaling molecule involved in immune response in mammals suggests that researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model, scientists say.

4 Oct 2005

Gleevec's uses might expand even further

Gleevec (Imatinib) is a representative of the newest generation of cancer drugs. The substance conveys its potent anti-proliferative effect by selectively supressing the tyrosine kinase pathway. The Giessen lung researchers now issue a first report of this substance as a new target therapy for pulmonary hypertension

4 Oct 2005

Ubiquitin ligase Rnf6 may be involved in oncogenesis

In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.

3 Oct 2005

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

3 Oct 2005

Pulsing heart cell provides clues into how heart disease develops

A pulsing heart cell is giving Oregon Health & Science University researchers insight into how it sends and receives signals, and that's providing clues into how heart disease and other disorders develop.

27 Sep 2005

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

...a discovery that could pave the way for more effective cancer treatments.

27 Sep 2005

First step towards effective drug-addiction therapies

A novel chemical compound that blocks memory-related drug cravings has the potential to be the basis of new therapies to aid drug-addiction recovery efforts, UC Irvine neurobiologists have found.

26 Sep 2005

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Their findings, which may point to new approaches to developing improved treatment options for the disease, are published in the journal Nature.

26 Sep 2005

Nanogen issued patent relating to biological screening device

Nanogen announced today it was issued Patent No. 6,942,778, "Microstructure Apparatus and Method for Separating Differently Charged Molecules Using an Applied Electric Field" by the U.S. Patent and Trademark Office.

26 Sep 2005

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Scientists from J. Craig Venter Institute, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine identified three novel mutations in two receptor tyrosine kinases in glioblastoma tumors using high throughput sequencing.

26 Sep 2005

Raf Kinase Inhibitor Protein plays a role in controlling the active movement of cells

University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells. The finding may suggest new pharmaceutical therapies for treating a variety of diseases, including cancer.

26 Sep 2005

Study clarifies insulin's role in blocking release of energy in patients with type II diabetes

Chronically high levels of insulin, as is found in many people with obesity and Type II diabetes, may block specific hormones that trigger energy release into the body, according to researchers at the University of California, San Diego (UCSD) School of Medicine.

22 Sep 2005

Possible new target for treating obesity and diabetes

The new target, a molecule called hVps34, is activated by amino acids (nutrients) entering the cell. This molecule triggers the activation of an enzyme, S6 Kinase 1 (S6K1), whose function UC researchers linked last year to obesity and insulin resistance.

19 Sep 2005

Tarceva should be tested as front-line therapy for older lung cancer patients

The tyrosine kinase inhibitor erlotinib (Tarceva) showed encouraging activity with relatively tolerable side effects in elderly, previously untreated patients with advanced non-small cell lung cancer (NSCLC), reports a team led by investigators from Dana-Farber Cancer Institute in Boston.

19 Sep 2005

Scientists have discovered a new and potent anti-cancer compound in beans

Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound - inositol pentakisphosphate - found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth.

19 Sep 2005

First genetic evidence that protein synthesis is critical for the regulation of memory formation

A group of Montreal researchers has discovered that GCN2, a protein in cells that inhibits the conversion of new information into long-term memory, may be a master regulator of the switch from short-term to long-term memory.

29 Aug 2005

Kinase News and Research

Australian researchers determine structure of JAK2 kinase, huge implications for development of new cancer drugs

Scientists gain better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases

Study identifies molecular switch that integrates cell survival signals from multiple intracellular signaling pathways

GRK5 protein plays important role in hypertension

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

Gleevec's uses might expand even further

Ubiquitin ligase Rnf6 may be involved in oncogenesis

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

Pulsing heart cell provides clues into how heart disease develops

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

First step towards effective drug-addiction therapies

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Nanogen issued patent relating to biological screening device

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Raf Kinase Inhibitor Protein plays a role in controlling the active movement of cells

Study clarifies insulin's role in blocking release of energy in patients with type II diabetes

Possible new target for treating obesity and diabetes

Tarceva should be tested as front-line therapy for older lung cancer patients

Scientists have discovered a new and potent anti-cancer compound in beans

First genetic evidence that protein synthesis is critical for the regulation of memory formation

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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