Kinase News and Research

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Sunitinib malate shows promise against advanced form of lung cancer

Results of a multi-center clinical study of a drug currently approved for treatment of kidney cancer indicate that it may also be effective for people with recurrent and advanced lung cancer.

5 Jun 2006

New data show Enzastaurin's activity across multiple cancer cell lines

Eli Lilly and Company's enzastaurin, an investigational, multi-targeted therapy that is currently the focus of two global Phase III clinical trials, one for the treatment of glioblastoma and one in non-Hodgkin's lymphoma

5 Jun 2006

Cause of neurodegeneration in Huntington's disease discovered

The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.

1 Jun 2006

New study may advance treatments to prevent type 2 diabetes and metabolic syndrome

Insulin uses two distinct mechanisms to control glucose and the metabolism of blood fats (lipids) in the liver, a new Joslin Diabetes Center-led study has discovered.

23 May 2006

Novel animal model of lung adenocarcinoma

Drs. Katerina Politi, Harold Varmus and colleagues at the Memorial Sloan Kettering Cancer Center in New York have developed a novel animal model of lung adenocarcinoma that will be of great use in testing the efficacy of targeted therapies against human lung cancer.

17 May 2006

Sulforaphane shown to inhibit the occurrence of hereditary colon cancer

Need another reason to eat vegetables? A new study at Rutgers shows that certain vegetables - broccoli and cauliflower, in particular - have natural ingredients that may reduce the risk of developing hereditary cancers.

17 May 2006

New compound shows unique potency against cancer cell proliferation

By determining how a class of compounds blocks signaling in cells, University of California, San Francisco (UCSF) scientists have identified what is perhaps the most potent drug candidate yet against a highly lethal kind of brain tumor.

16 May 2006

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo.

16 May 2006

Mental activity leads to mental agility

Scientists have long known that brains need neural activity to mature and that sensory input is most important during a specific window of time called the "critical period" when the brain is primed for aggressive learning.

10 May 2006

New treatment for chronic eosinophilic leukemia

Leukemia - or cancer of the bone marrow - strikes some 700 Belgians each year. Chronic Eosinophilic Leukemia (CEL), a specific form of leukemia, is currently treated with Glivec.

10 May 2006

New understanding of chromosomal glue

Researchers have a new understanding of the process cells use to ensure that sperm and eggs begin life with exactly one copy of each chromosome - a process that must be exquisitely regulated to prevent problems such as miscarriages and mental retardation.

8 May 2006

Inhibiting cell process may give cancer drug a boost

A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug, according to findings appearing in the May 3 issue of the European Journal of Cancer.

3 May 2006

Three-dimensional breast cell cultures reveal clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting.

3 May 2006

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Researchers believe they have found a way to change the action of 60 percent of currently available medications, in some cases making them many times more effective, according to an article published in the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseases including heart disease, cancer, diabetes, depression and arthritis. The study describes a new way to manipulate perhaps the most important signaling mechanism in human cells: G-protein coupled receptors (GPCRs).

28 Apr 2006

New research links metabolism and appetite suppression, opening door to obesity treatments

A team led by a Canadian researcher has discovered a process by which a small protein acts directly within muscles to increase the body's metabolism to burn fat while simultaneously suppressing appetite.

19 Apr 2006

Researchers identify novel agent that protects neurons involved in Parkinson's disease from being destroyed by rotenone

Researchers at the University at Buffalo affiliated with the New York State Center of Excellence in Bioinformatics and Life Sciences have identified a novel agent that can protect neurons involved in Parkinson's disease from being destroyed by the pesticide rotenone.

18 Apr 2006

Genetic switch that links animal growth and cancer

Laboratory discoveries by scientists at two universities may lead to new directions in cancer therapy drugs. The researchers have discovered that a genetic switch involved in growth and development of an animal is the same one used to prevent normal cells from becoming cancerous.

18 Apr 2006

Lack of response to herceptin may be reversed with PI3K inhibiting agents

Breast cancer patients with HER2-positive tumors who don't respond to Herceptin (trastuzumab) may benefit from cocktail therapy that includes Herceptin along with one or more PI3K inhibiting agents, say researchers at the University of Texas M. D. Anderson Cancer Center.

11 Apr 2006

Whole genome analysis of the protein kinases from Dictyostelium

The journal PLoS Genetics has published the findings of a team of scientists at the nonprofit Boston Biomedical Research Institute that provides a whole genome analysis of the protein kinases from a scientifically valuable model organism known as Dictyostelium.

10 Apr 2006