Knockout Mouse News and Research

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New understanding of role hyaluronic acid in skeletal growth

Investigators at Burnham Institute for Medical Research (Burnham) and the University of Connecticut Health Center (U.C.H.C.) have gained new understanding of the role hyaluronic acid (HA) plays in skeletal growth, chondrocyte maturation and joint formation in developing limbs.

12 Aug 2009

Discovery of a protein link to wound healing

Diabetes and eczema may appear to be two completely unrelated diseases.

24 Mar 2009

New understanding of blinding degenerative eye conditions

Though based on mouse studies, the research bolsters the idea that humans suffering from these and other eye conditions may be able to help preserve function by adding antioxidants to their diet, and explains why this would work.

8 Feb 2009

New research may lead to new pharmacologic approaches to treating obesity

Scientists at the University of North Carolina at Chapel Hill School of Medicine have discovered a gene that when mutated causes obesity by dampening the body's ability to burn energy while leaving appetite unaffected.

5 Feb 2009

How short RNAs influence many proteins

During the last decade, microRNAs have emerged somewhat surprisingly as key players in the way genes are regulated. These short snippets of RNA do their work by interacting with messenger RNAs, which act as blueprints for protein creation.

6 Aug 2008

An inflamed response

Paul Martin, Professor of Cell Biology in the University of Bristol Departments of Physiology and Pharmacology, and Biochemistry, talked to Cherry Lewis about the discovery made in his lab that speeds up wound healing and reduces the size of the wound scar. She was interested not only in the discovery itself, but also in the processes and years of research that led up to it.

15 Jul 2008

Two-way cell talk provides clues about neuromuscular disease

It's a scientific given that neurons tell other cells what to do, but new evidence suggests that, like with any good relationship, these target cells also have much to contribute, scientists say.

17 Feb 2008

How asthma and allergy symptoms are triggered

In demonstrating that a group of calcium ion channels play a crucial role in triggering inflammatory responses, researchers at Beth Israel Deaconess Medical Center (BIDMC) have not only solved a longstanding molecular mystery regarding the onset of asthma and allergy symptoms, but have also provided a fundamental discovery regarding the functioning of mast cells.

15 Jan 2008

6,000 genes help determine body weight

Reporting in the online journal BMC Genetics, researchers from the Monell Center have for the first time attempted to count the number of genes that contribute to obesity and body weight.

15 Jan 2008

Inflammation causes insulin resistance not obesity

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes.

6 Nov 2007

How the brain produces fever responses during infections

With the finding that fever is produced by the action of a hormone on a specific site in the brain, scientists have answered a key question as to how this adaptive function helps to protect the body during bacterial infection and other types of illness.

6 Aug 2007

Check and balance for neuron activity provides insight into schizophrenia, seizures

Two genes important for human development and implicated in cancer and schizophrenia also help keep a healthy balance between excitation and inhibition of brain cells, researchers say.

24 May 2007

World's first microRNA knockout mouse

A role for a microRNA in the immune system has been shown by study of one of the world's first microRNA knockout mouse, reported in Science.

27 Apr 2007

Scientists spot mechanism behind promising new sleep drug

An experimental drug called gaboxadol may soon help millions of bleary-eyed insomniacs get to sleep, and a multi-center team of U.S. scientists believes they've pinpointed just how the drug works.

1 Nov 2006

NIH launches "Knockout Mouse Project"

The National Institutes of Health (NIH) today awarded a set of cooperative agreements, totaling up to $52 million over five years, to launch the Knockout Mouse Project.

7 Sep 2006

Kidney treatments may be improved with new understanding of cell death mechanism

Finding how two proteins conspire to get kidney cells to self-destruct when oxygen supplies are low may one day improve dismal mortality rates for ischemic renal failure, researchers say.

23 Apr 2006

New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease.

13 Mar 2006

Cellular signal may determine life or death for damaged brain cells

Scientists at the Universities of Heidelberg and Ulm and a unit of the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have discovered that a specific signal within brain cells may determine whether they live or die after a stroke.

13 Nov 2005

Mouse model of Rett Syndrome displays reduced cortical activity

Sacha Nelson of Brandeis University in Waltham, MA and Rudolf Jaenisch of the Whitehead Institute of Biomedical Research in Cambridge, MA and their colleagues report online in the Proceedings of the National Academy of Sciences Early Edition that spontaneous neuronal activity is reduced in the cortex of a knockout mouse model for the childhood neurodevelopmental disorder, Rett Syndrome.

23 Aug 2005

Nutrition gene key in regulating immune system

A gene that signals a yeast cell to make bread rise and mice to eat a better diet also helps selectively silence the immune system, researchers have found.

18 May 2005