Large Intestine News and Research

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Preclinical safety data reports Natural S-equol has little effect on 2 reproductive hormones

Natural S-equol, a novel soy germ-based compound, is very likely the primary ingredient for reducing hot flushes in the dietary supplement SE5-OH, which is under development for reduction of menopause symptoms, according to pre-clinical efficacy data from studies using an animal model presented at the Experimental Biology 2010 annual meeting.

3 May 2010

Albireo to present study results of A3309 in patients with chronic constipation at 2010 DDW annual meeting

Albireo today announced that additional clinical data will be reported from a recent study assessing the safety, tolerability and efficacy of A3309 in patients with chronic constipation. A3309 is a first-in-class investigational compound for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic constipation (CC). The results will be presented during the 2010 Digestive Disease Week (DDW) annual meeting being held in New Orleans, US.

29 Apr 2010

SE5-OH with Natural S-equol supplement appears to be safe for pre- and post-menopausal women

Healthy pre-and post-menopausal Japanese women who took a supplement of SE5-OH containing Natural S-equol, a novel soy germ-based ingredient under development for the management of menopausal symptoms, had measures of reproductive hormones that stayed within normal limits throughout the study.

3 Apr 2010

Bile secretions in small intestine send signals to disease-causing gut bacteria

Bile secretions in the small intestine send signals to disease-causing gut bacteria allowing them to change their behavior to maximize their chances of surviving, Montana State University research associate Steve Hamner told the Society for General Microbiology during its spring meeting in Edinburgh, Scotland.

1 Apr 2010

T1D and IBD may respond to 2-way genetic switch: Study

Pediatric researchers analyzing DNA variations in type 1 diabetes and inflammatory bowel disease have found a complex interplay of genes. Some genes have opposing effects, raising the risk of one disease while protecting against the other. In other cases, a gene variant may act in the same direction, raising the risk for both diseases.

23 Mar 2010

Risk of hereditary form of bowel cancer: New preparation of omega-3 holds hope

A new preparation of an omega-3 polyunsaturated fatty acid found naturally in fish, offers hope for thousands of patients at risk of developing an inherited form of bowel cancer, a new study shows.

18 Mar 2010

Genes linked to ulcerative colitis identified

A study of the human genome led by Cedars-Sinai researchers has now identified genes linked to ulcerative colitis, offering clues as to what causes the condition and potential avenues for new therapies to treat the disease.

18 Mar 2010

M. D. Anderson Cancer Center recommends colonoscopy screening to reduce risk of colon cancer

M. D. Anderson Cancer Center are encouraging men and women to learn more about colon polyps and how they affect a person's risks for cancer.

11 Mar 2010

Combination of blueberries and probiotics protects against intestinal disorders

It is already known that blueberries are rich in antioxidants and vitamins. New research from the Lund University Faculty of Engineering in Sweden shows that blueberry fibre are important and can alleviate and protect against intestinal inflammations, such as ulcerative colitis.

9 Feb 2010

Preoperative CT may help reduce unnecessary surgeries in women with suspected acute appendicitis

Preoperative computed tomography (CT) may help reduce unnecessary surgeries in women of reproductive age with suspected acute appendicitis, according to a new study appearing in the February issue of the journal Radiology.

27 Jan 2010

Data may help identify severity of ulcerative colitis in high-risk patients

Ulcerative colitis (UC) is a chronic disease involving the large intestine which causes inflammation along with local and systemic symptoms. It affects individuals worldwide, with a higher prevalence in Canada. The course of this disease has long been unpredictable, with remission possible in some patients and frequent recurrence in others.

20 Jan 2010

TMZ and small molecule combination appears to lower tumor resistance

University of Florida researchers have found a way to use just a fraction of the normal dosage of a highly toxic, debilitating chemotherapy drug to achieve even better results against colon cancer cells.

9 Dec 2009

Additional data from ChemoCentryx' study of Traficet-EN in Crohn's disease patients

In addition to data released in late November, ChemoCentryx, Inc., announced today more data from the Company's PROTECT-1 (the Prospective Randomized Oral Therapy Evaluation in Crohn's disease Trial) of Traficet-EN(TM) (CCX282-B) in patients with moderate-to-severe Crohn's disease.

8 Dec 2009

Long-chain omega-3 fatty acids can prevent colorectal cancer

Long-chain omega-3 fatty acids, primarily found in fish and seafood, may have a role in colorectal cancer prevention, according to results presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference, held Dec. 6-9, 2009, in Houston.

8 Dec 2009

Selenium-based antioxidant compound reduces risk of colorectal cancer

Supplementation with a selenium-based antioxidant compound decreased the risk of developing new polyps of the large bowel — called colorectal metachronous adenomas — in people who previously had colorectal polyps removed.

8 Dec 2009

Research team identifies five new gene regions that raise the risk of childhood-onset IBD

In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.

16 Nov 2009

CCEC relocates to a new place

Central California Endoscopy Center is proud to announce it has moved into its new, larger facility. Central California Endoscopy Center (CCEC) is now located at 7055 N. Fresno Street, in Suite 100 Fresno, CA 93720. We began to serve patients November 5, 2009.

6 Nov 2009

Shortage of general surgeons may be linked to higher rate of perforated appendix in rural areas

People who live in rural areas may run a greater risk of having perforated appendix than those in suburban and urban areas, according to a new study out of Dartmouth Medical School, Lebanon, NH. Not having enough general surgeons in rural regions may explain the disparity, according to researchers who presented their findings at the 95th annual Clinical Congress of the American College of Surgeons.

15 Oct 2009

New soy germ-based ingredient improves menopausal symptoms

SE5-OH containing Natural S-equol, a novel soy germ-based ingredient in a supplement, improved menopausal symptoms, including significantly reducing hot flash frequency by nearly 59 percent, according to a peer-reviewed study in Japanese women.

9 Oct 2009

Drugs blocking the effects of ACh may prevent cancer

By seeing what substances and molecules affect the development of our diseases, we can develop drugs that prevent or cure diseases. In her dissertation at Kalmar University in Sweden, Ann Novotny has found that the signal molecule acetylcholine (ACh) is important for the progress of cancer of the large intestine and colon, knowledge that is important to factor in when developing drugs that block the effects of Ach on tumor cells.

23 Sep 2009

Large Intestine News and Research

Preclinical safety data reports Natural S-equol has little effect on 2 reproductive hormones

Albireo to present study results of A3309 in patients with chronic constipation at 2010 DDW annual meeting

SE5-OH with Natural S-equol supplement appears to be safe for pre- and post-menopausal women

Bile secretions in small intestine send signals to disease-causing gut bacteria

T1D and IBD may respond to 2-way genetic switch: Study

Risk of hereditary form of bowel cancer: New preparation of omega-3 holds hope

Genes linked to ulcerative colitis identified

M. D. Anderson Cancer Center recommends colonoscopy screening to reduce risk of colon cancer

Combination of blueberries and probiotics protects against intestinal disorders

Preoperative CT may help reduce unnecessary surgeries in women with suspected acute appendicitis

Data may help identify severity of ulcerative colitis in high-risk patients

TMZ and small molecule combination appears to lower tumor resistance

Additional data from ChemoCentryx' study of Traficet-EN in Crohn's disease patients

Long-chain omega-3 fatty acids can prevent colorectal cancer

Selenium-based antioxidant compound reduces risk of colorectal cancer

Research team identifies five new gene regions that raise the risk of childhood-onset IBD

CCEC relocates to a new place

Shortage of general surgeons may be linked to higher rate of perforated appendix in rural areas

New soy germ-based ingredient improves menopausal symptoms

Drugs blocking the effects of ACh may prevent cancer

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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