Large Intestine News and Research

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Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

Takeda Pharmaceutical Company Limited today announced results from the phase 3 VISIBLE 1 clinical trial evaluating the efficacy and safety of an investigational subcutaneous formulation of the gut-selective biologic vedolizumab for maintenance therapy in adult patients with moderately to severely active ulcerative colitis who achieved clinical response* at week 6 following two doses of open-label vedolizumab intravenous induction therapy.

22 Oct 2018

Fiber strengthens intestinal barrier and counteracts gastrointestinal problems

Similar to patients with Crohn's disease, elderly people with stomach problems have a intestinal barrier that is not functioning optimally.

7 Sep 2018

Researchers develop new way of testing bacterial resistance to antibiotics

A new method to analyze a commonly understood route for antibiotic resistance could lead to earlier detection of antibiotic resistant bacteria.

14 Aug 2018

Probiotic use could result in disorienting brain fogginess and rapid belly bloating

Probiotic use can result in a significant accumulation of bacteria in the small intestine that can result in disorienting brain fogginess as well as rapid, significant belly bloating, investigators report.

6 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease.

27 Jun 2018

Study: Long-term estrogen therapy alters microbial composition and activity in the gut

Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found.

20 Jun 2018

Researchers find identity of stem-cell niche of the colon

Researchers at the University of Zurich have discovered the identity of the stem-cell niche of the colon. The niche comprises special cells that activate the stem cells of the adjacent intestinal epithelium and are responsible for its continuous renewal.

7 Jun 2018

Researchers manipulate bacterial species in the gut using diet

Scientists from Stanford University School of Medicine have shown that by manipulating diet in a mouse model, it is possible to favor the engraftment of a specific bacterial strain over others.

10 May 2018

Changing metabolic states of intestinal bacteria have an effect on MAIT defense cells

A little-explored group of immune cells plays an important role in the regulation of intestinal bacteria.

9 May 2018

Western diets promote bacterial growth in the small intestine, increase fat digestion and absorption

A researcher at Midwestern University led a new study showing that Western diets, high in fat and simple sugar, promote the growth of bacteria in the small intestine that increase fat digestion and absorption.

27 Apr 2018

'Gut-on-a-chip' model recreates intestinal matrix critical for nutrient absorption

The difficulties of conducting research on the human gut are substantial: the presence of trillions of bacterial cells interacting with human cells and each other, constant environmental changes every time food is consumed and zero chance of conducting trials that control for all those moving parts.

18 Apr 2018

Specific small-bowel microbes regulate digestion and absorption of fats, study shows

Although the vast majority of research on the gut microbiome has focused on bacteria in the large intestine, a new study-;one of a few to concentrate on microbes in the upper gastrointestinal tract-;shows how the typical calorie-dense western diet can induce expansion of microbes that promote the digestion and absorption of high-fat foods.

11 Apr 2018

Routine screenings and early detection can help protect from colorectal cancer

Having a colonoscopy to screen for colorectal cancer is not on anyone's list of favorite activities. However, with colorectal cancer ranking as the second leading cause of cancer death in the United States, undergoing the outpatient procedure as per the Centers for Disease Control's (CDC) guidelines may be one of the smartest things you can do for your overall health.

9 Mar 2018

Refusing surgery decreases chance of beating esophageal cancer, study finds

Patients with esophageal cancer who refuse surgery when it is recommended are less likely to survive long term than similar groups of patients who undergo an operation, according to research presented today at the 54th Annual Meeting of The Society of Thoracic Surgeons.

30 Jan 2018

Fusobacterium may play role in colon cancer growth, study finds

Like nomads who carry tokens of home on their travels, colorectal cancer cells that spread to other parts of the body appear to bring several of the species of bacteria that were their companions in the colon, Dana-Farber Cancer Institute scientists report in a new study in the journal Science.

7 Dec 2017

Capsule research could transform treatment for C. difficile infections

An Alberta-led clinical trial has shown Fecal Microbiota Transplant (FMT) is as effective in treating clostridium difficile (C. difficile) infections whether delivered by colonoscopy or by swallowing capsules.

28 Nov 2017

Intestinal barrier of IBS patients allows bacteria to pass more freely than in healthy people

The intestinal barrier of patients with the gastrointestinal disease IBS allows bacteria to pass more freely than in healthy people, according to a study led by researchers at Linköping University in Sweden. The study, published in the scientific journal Gastroenterology, is the first to investigate IBS using living bacteria.

5 Sep 2017

Blood test using infrared spectroscopy could provide cheaper, quicker alternative for colitis screening

A fast, simple blood test for ulcerative colitis using infrared spectroscopy could provide a cheaper, less invasive alternative for screening compared to colonoscopy, which is now the predominant test, according to a study between the Department of Physics and Astronomy and the Institute for Biomedical Sciences at Georgia State University.

23 Aug 2017

Human colon organoids fill gap in effectively modeling common GI diseases

Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell.

22 Jun 2017