Lipitor (Atorvastatin) News and Research

RSS
Atorvastatin (INN) (Lipitor, Pfizer), is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Atorvastatin inhibits HMG-CoA reductase, the rate-determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the synthesis of cholesterol and other mevalonate derivatives. This lowers the amount of cholesterol produced which in turn lowers the total amount of LDL cholesterol. Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer). With 2006 sales of US$12.9 billion, Lipitor is the largest-selling drug in the world.
Low blood pressure may increase risk of heart attack and stroke

Low blood pressure may increase risk of heart attack and stroke

Statins for the prevention of dementia

Statins for the prevention of dementia

Rockefeller University Hospital opens clinical trial into statin-associated muscle complaints

Rockefeller University Hospital opens clinical trial into statin-associated muscle complaints

New alternative to biopsy detects subtle changes in cancer cells

New alternative to biopsy detects subtle changes in cancer cells

House subcommittee to conduct hearing to discuss strategies to end agreements between brand-name, generic drugmakers, limit number of plans

House subcommittee to conduct hearing to discuss strategies to end agreements between brand-name, generic drugmakers, limit number of plans

NTRILIPIX (fenofibric acid) in combo with Rosuvastatin calcium shows improvement on key lipids for cholesterol management

NTRILIPIX (fenofibric acid) in combo with Rosuvastatin calcium shows improvement on key lipids for cholesterol management

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Statins may treat cerebral cavernous malformation

Statins may treat cerebral cavernous malformation

Framingham and National Cholesterol Education Program tools do not accurately predict coronary heart disease

Framingham and National Cholesterol Education Program tools do not accurately predict coronary heart disease

Seniors warned about mixing OTC and prescription drugs

Seniors warned about mixing OTC and prescription drugs

Statins do not interfere with Rituximab treatment for lymphomas

Statins do not interfere with Rituximab treatment for lymphomas

Good advice to cut prescription drug costs

Good advice to cut prescription drug costs

Metabolex announces positive results from phase 2 trial of MBX-8025

Metabolex announces positive results from phase 2 trial of MBX-8025

Do statins cause muscle problems?

Do statins cause muscle problems?

Experts say thousands at risk for heart disease go unchecked

Experts say thousands at risk for heart disease go unchecked

Cholesterol lowering drugs may protect against dementia

Cholesterol lowering drugs may protect against dementia

Ranbaxy and Pfizer settle on Lipitor patent litigation

Ranbaxy and Pfizer settle on Lipitor patent litigation

Hearing to focus on direct-to-consumer ads for prescription drugs

Hearing to focus on direct-to-consumer ads for prescription drugs

Lipitor and Celebrex combined may halt prostate cancer

Lipitor and Celebrex combined may halt prostate cancer

Cancer prevention

Cancer prevention