Liver News and Research

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Sirtuins help fight off obesity-linked diseases

A protein that slows aging in mice and other animals also protects against the ravages of a high-fat diet, including diabetes, according to a new MIT study.

9 Aug 2012

Theranostic imaging targets and tracks potent drug therapies to prostate cancer cells

Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones.

9 Aug 2012

Prostate cancer cells can be killed by theranostic imaging without harming healthy cells

Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones.

8 Aug 2012

WSU researchers to test novel hypothesis that cardiolipin deficiency leads to disruption of TCA cycle

Barth Syndrome (BTHS) is a rare and serious genetic disorder that primarily affects males and is passed from mother to son; women who are carriers do not show symptoms of the disorder. Fifty percent of children born to a mother who is a carrier will inherit the defective gene, and all daughters born to an affected man will be carriers. BTHS is caused by a mutation in the tafazzin gene that results in decreased production of cardiolipin, an essential lipid for energy metabolism.

8 Aug 2012

Study reports new potential NOX inhibitor therapy for liver fibrosis

A study published in the online journal Hepatology reports a potential new NADPH oxidase (NOX) inhibitor therapy for liver fibrosis, a scarring process associated with chronic liver disease that can lead to loss of liver function.

8 Aug 2012

New research hopes to uncover mystery behind breast cancer metastasis

If detected early, most cases of breast cancer are curable. But if the tumour has metastasized - or spread to a site outside of the breast - cure rates decline. A team of researchers from Lawson Health Research Institute and Western University have received $449,733 from the Canadian Breast Cancer Foundation - Ontario Region to study a rare subpopulation of tumour cells called cancer stem cells (CSCs) in hopes of uncovering the mystery behind metastasis.

8 Aug 2012

Geisel professor concerned about steroid abuse by adolescents

Leslie Henderson is concerned about steroid abuse, not necessarily by sports luminaries like Barry Bonds and Mark McGwire, but rather by adolescents.

7 Aug 2012

Novartis’ pasireotide offers symptom relief for patients with advanced neuroendocrine tumors

A researcher at Moffitt Cancer Center and his international team of colleagues have reported study results on a novel multireceptor-targeted somatostatin analogue called pasireotide (SOM230) manufactured by Novartis Pharma AG.

7 Aug 2012

Creatine may fight major depression in women

Women battling stubborn major depression may have a surprising new ally in their fight—the muscle-building dietary supplement creatine.

7 Aug 2012

Assumptions about liver transplant wait-list mortality challenged

The majority of liver patients who die on, or are removed from, the transplant wait-list have declined an offer of transplant, show the findings of an American study.

6 Aug 2012

Novel multireceptor-targeted somatostatin analogue found effective against neuroendocrine tumors

6 Aug 2012

Neutrophils play an unexpected role in mediating insulin resistance

Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance - the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans.

6 Aug 2012

TAT-ARC fusion protein helps treat acute liver failure

Acute liver failure is a life-threatening disease, characterized by a sudden, massive death of liver cells. Unfortunately, few treatment options exist, especially for advanced-stage liver failure. As a last resort a liver transplant may be the only remaining option.

3 Aug 2012

Mechanism provides beneficial characteristics of energy-burning brown fat to white fat

Columbia University Medical Center (CUMC) researchers have identified a mechanism that can give energy-storing white fat some of the beneficial characteristics of energy-burning brown fat. The findings, based on studies of mice and of human fat tissue, could lead to new strategies for treating obesity and type 2 diabetes.

3 Aug 2012

Hint of tafamidis benefit in rare polyneuropathy

The results of a randomized trial suggest that tafamidis treatment may slow the progression of early-stage V30M transthyretin familial amyloid polyneuropathy.

2 Aug 2012

MLK3 protein critical driver of breast cancer cell migration and invasion

By identifying a key protein that tells certain breast cancer cells when and how to move, researchers at Michigan State University hope to better understand the process by which breast cancer spreads, or metastasizes.

2 Aug 2012

Pediatric liver transplant recipients have increased risk of death when from obese donors

Children undergoing liver transplantation are at greater risk of graft loss and death from adult organ donors who are severely obese according to research published in the August issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases. The study, funded in part by a grant from the National Institutes of Health (NIH), found that pediatric donor body mass index (BMI) did not increase mortality risk in this pediatric population.

1 Aug 2012

Liver News and Research

Sirtuins help fight off obesity-linked diseases

Theranostic imaging targets and tracks potent drug therapies to prostate cancer cells

Prostate cancer cells can be killed by theranostic imaging without harming healthy cells

WSU researchers to test novel hypothesis that cardiolipin deficiency leads to disruption of TCA cycle

Study reports new potential NOX inhibitor therapy for liver fibrosis

New research hopes to uncover mystery behind breast cancer metastasis

Geisel professor concerned about steroid abuse by adolescents

Novartis’ pasireotide offers symptom relief for patients with advanced neuroendocrine tumors

Creatine may fight major depression in women

Assumptions about liver transplant wait-list mortality challenged

Novel multireceptor-targeted somatostatin analogue found effective against neuroendocrine tumors

Neutrophils play an unexpected role in mediating insulin resistance

TAT-ARC fusion protein helps treat acute liver failure

Mechanism provides beneficial characteristics of energy-burning brown fat to white fat

Hint of tafamidis benefit in rare polyneuropathy

MLK3 protein critical driver of breast cancer cell migration and invasion

Pediatric liver transplant recipients have increased risk of death when from obese donors

Childhood obesity could be related to growing problems with infertility

Researchers discover new approach to treat two lethal metastatic cancers

Biomimetic bioartificial livers and cell toxicity assays: an interview with Dr. Joris Braspenning, CEO Medicyte

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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