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Genentech submits vismodegib NDA to FDA for treatment of advanced basal cell carcinoma

Genentech, a member of the Roche Group, today announced that the company has submitted a New Drug Application for vismodegib to the U.S. Food and Drug Administration (FDA) for the treatment of people with advanced basal cell carcinoma (BCC) for whom surgery is considered inappropriate.

12 Sep 2011

ASTMH annual meeting to explore latest research on infectious diseases

The 60th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH) -- the largest of its kind in the world -- will bring together in one place global experts who are battling a wide range of bacteria, viruses, parasites and other pathogens that each year kill or sicken hundreds of millions of people.

12 Sep 2011

Specialists propose changes to allocation and distribution of organs for liver transplants

Transplantation specialists have proposed changes to the allocation and distribution of organs used for liver transplants. The recommended policy modifications take into account the scarcity of available organs, ensuring rapid allocation and delivery of the organ to those most in need in order to reduce mortality for waitlisted patients.

12 Sep 2011

UMSOM to receive FDA approval for whole parasite malaria vaccine clinical trials

For the first time, a malaria vaccine that uses the entire malaria parasite has proven safe and shown promise to produce a strong immune response in a clinical trial, according to a new study co-authored by researchers at the University of Maryland School of Medicine Center for Vaccine Development.

12 Sep 2011

Autophagy also mobilizes and exports cholesterol from cells

Researchers at the University of Ottawa Heart Institute (UOHI) have discovered that an ancient pathway called autophagy also mobilizes and exports cholesterol from cells.

9 Sep 2011

Landmark discovery in rapid spread of PRL-3 oncoprotein associated aggressive cancers

Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have made a landmark discovery in the battle against the rapid spread of aggressive cancers associated with PRL-3 oncoprotein.

9 Sep 2011

Longer looks: Unknowns in sports medicine; shackling pregnant prisoners

Medical experts say that multiple futile treatments is all too familiar and points to growing problems in sports medicine, a medical subspecialty that has been experiencing explosive growth. now researchers are questioning many of the procedures, including new ones that often have no rigorous studies to back them up. "Patients come in and say, 'I want the same thing that Tiger Woods had,' " said Dr. McDevitt, the sports medicine orthopedist in Maryland.

9 Sep 2011

UOHI team identifies that autophagy also mobilizes and exports cholesterol from cells

Researchers at the University of Ottawa Heart Institute (UOHI) have discovered that an ancient pathway called autophagy also mobilizes and exports cholesterol from cells.

9 Sep 2011

Positive results from Sanaria PfSPZ Vaccine initial Phase 1 trial on malaria

Positive results from the initial Phase 1 clinical trial in 80 healthy volunteers and complementary pre-clinical studies of the Sanaria PfSPZ Vaccine are published today in the online issue of Science.

9 Sep 2011

Inhibition of Sab protein protects liver from acetaminophen toxicity

New research from the Keck School of Medicine of the University of Southern California (USC) may help prevent damage to the liver caused by drugs like acetaminophen and other stressors.

8 Sep 2011

New surprising discovery on division of mitochondria within cells

A surprising new discovery by the University of Colorado Boulder and the University of California, Davis regarding the division of tiny "power plants" within cells known as mitochondria has implications for better understanding a wide variety of human diseases and conditions due to mitochondrial defects.

8 Sep 2011

Loss of estrogen receptor alpha protein may lead to metabolic syndrome

UCLA researchers demonstrated that loss of a key protein that regulates estrogen and immune activity in the body could lead to aspects of metabolic syndrome, a combination of conditions that can cause Type 2 diabetes, atherosclerosis and cancer. Called estrogen receptor alpha, this protein is critical in regulating immune system activity such as helping cells suppress inflammation and gobble-up debris.

7 Sep 2011

SFDA approves MedWaves' AveCure microwave coagulation-ablation system for cancer

MedWaves' AveCure microwave coagulation-ablation (MWA) system uses microwave energy to volumetrically coagulate-ablate (destroy) soft-tissue lesions safely, effectively, precisely and with repeatability.

7 Sep 2011

London scientist hopes to improve diagnosis for Jeune syndrome

A London scientist is hoping a new study funded by children's charity Action Medical Research, will help to improve diagnosis and work towards new treatments for a rare, incurable genetic disorder called Jeune syndrome.

7 Sep 2011

Robert Gordon University scientists to develop new treatment for cystinosis

A team of researchers at Robert Gordon University has secured a six figure sum from Sparks, a leading children’s medical research charity, to develop a revolutionary treatment for a rare genetic disorder.

6 Sep 2011

Pharmasset reports SVR results from PSI-7977 phase 2b combination study on HCV genotype 1

Pharmasset, Inc., announced today sustained virologic response (SVR) results from its phase 2b PROTON study with PSI-7977 400 mg dosed once daily in combination with peginterferon alfa 2a and ribavirin (Peg-IFN/RBV) in subjects with hepatitis C virus (HCV) genotype 1 who have not been treated previously. 43 out of 44 (98%) evaluable subjects achieved an SVR12, defined as HCV RNA below the limit of detection (<15 IU/mL) 12 weeks after the completion of treatment.

6 Sep 2011

AMT, NIH enter exclusive license agreement for use of AAV5-based gene therapy vectors

Amsterdam Molecular Therapeutics, a leader in the field of human gene therapy, today announced that it has entered into an exclusive license agreement with the US National Institutes of Health (NIH) for use of adeno-associated virus serotype 5 (AAV5)-based gene therapy vectors for liver and brain indications.

6 Sep 2011

BioAlliance Pharma announces oral communication of Livatag Phase II trial results on liver cancer

BioAlliance Pharma SA, a company dedicated to specialty and orphan oncology products, today announces oral communication of the Phase II clinical trial results of its orphan product Livatag at the annual congress of ILCA, the only international organization devoted exclusively to liver cancer research with participation of worldwide best specialists.

6 Sep 2011

Inflammation boosts activity of two proteins that can normalize blood sugar in diabetics

Increased low-grade inflammation in the body resulting from obesity is widely viewed as contributing to type 2 diabetes. Going against this long-held belief, researchers from Children's Hospital Boston report that two proteins activated by inflammation are actually crucial for maintaining good blood sugar levels - and that boosting the activity of these proteins can normalize blood sugar in severely obese and diabetic mice.

5 Sep 2011

First report of alternative lengthening of telomeres in human cancer subtypes

The first report of the presence of alternative lengthening of telomeres (ALT) in cancers arising from the bladder, cervix, endometrium, esophagus, gallbladder, liver, and lung was published today in The American Journal of Pathology. The presence of ALT in carcinomas can be used as a diagnostic marker and has implications for the development of anti-cancer drug therapies.

3 Sep 2011

Liver News and Research

Genentech submits vismodegib NDA to FDA for treatment of advanced basal cell carcinoma

ASTMH annual meeting to explore latest research on infectious diseases

Specialists propose changes to allocation and distribution of organs for liver transplants

UMSOM to receive FDA approval for whole parasite malaria vaccine clinical trials

Autophagy also mobilizes and exports cholesterol from cells

Landmark discovery in rapid spread of PRL-3 oncoprotein associated aggressive cancers

Longer looks: Unknowns in sports medicine; shackling pregnant prisoners

UOHI team identifies that autophagy also mobilizes and exports cholesterol from cells

Positive results from Sanaria PfSPZ Vaccine initial Phase 1 trial on malaria

Inhibition of Sab protein protects liver from acetaminophen toxicity

New surprising discovery on division of mitochondria within cells

Loss of estrogen receptor alpha protein may lead to metabolic syndrome

SFDA approves MedWaves' AveCure microwave coagulation-ablation system for cancer

London scientist hopes to improve diagnosis for Jeune syndrome

Robert Gordon University scientists to develop new treatment for cystinosis

Pharmasset reports SVR results from PSI-7977 phase 2b combination study on HCV genotype 1

AMT, NIH enter exclusive license agreement for use of AAV5-based gene therapy vectors

BioAlliance Pharma announces oral communication of Livatag Phase II trial results on liver cancer

Inflammation boosts activity of two proteins that can normalize blood sugar in diabetics

First report of alternative lengthening of telomeres in human cancer subtypes

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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