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Mipomersen Phase 3 trial in heFH meets primary, secondary and tertiary endpoints

Genzyme Corp. and Isis Pharmaceuticals Inc. announced that data from the phase 3 study of mipomersen in patients with heterozygous familial hypercholesterolemia (heFH) were presented today at the European Society of Cardiology's Congress 2010 in Stockholm, Sweden. The study met its primary endpoint with a 28 percent reduction in LDL-cholesterol, compared with an increase of 5 percent for placebo (p<0.001). The trial also met all of its secondary and tertiary endpoints.

2 Sep 2010

Pfizer enters agreement to acquire FoldRx Pharmaceuticals

Pfizer Inc. and FoldRx Pharmaceuticals, Inc., a privately held drug discovery and clinical development company, today announced that they have entered into an agreement under which Pfizer will acquire FoldRx.

2 Sep 2010

Beaumont Hospital expands new multi-organ transplant program

Beaumont Hospital, Royal Oak became Michigan's third liver transplant center on Aug. 31. A 59-year-old man from Royal Oak was the first patient to receive a liver transplant through Beaumont's new multi-organ transplant program.

2 Sep 2010

Leon-Berard Cancer Center to install CyberKnife VSI System

Accuray Incorporated, a global leader in the field of radiosurgery, today announced that the first CyberKnife VSI System to be installed in Europe was placed at the Leon-Berard Cancer Multidisciplinary Center in Lyon, France. The CyberKnife VSI System is the newest addition to the CyberKnife product family.

2 Sep 2010

Abbott RealTime HBV assay receives marketing approval from FDA

Abbott announced today it has received approval from the U.S. Food and Drug Administration to market the Abbott RealTime HBV assay for measuring viral load or the amount of hepatitis B virus in a patient's blood. It is the first and only approved test capable of automating HBV viral load testing from sample extraction to final results.

2 Sep 2010

Non-kidney transplant patients likely to undergo kidney transplant prior to dialysis: Study

Kidney failure may accompany or complicate transplantation of the liver, heart, or lung. Because increasing numbers of individuals are receiving non-kidney transplants, researchers have wondered whether more of such patients are being listed for kidney transplants.

2 Sep 2010

Phase 3 EINSTEIN-DVT clinical trial data can transform deep vein thrombosis treatment

Johnson & Johnson Pharmaceutical Research & Development, announced today that the investigational, oral anticoagulant rivaroxaban successfully demonstrated non-inferiority compared to the standard of care for the prevention of recurrent venous thromboembolism (VTE) in patients with acute symptomatic deep vein thrombosis (DVT), with a comparable safety profile.

31 Aug 2010

Cognizant Communication launches 'Cell Medicine' open access journal

A new and unique journal on cell transplantation aimed at helping translate laboratory findings into clinical applications is being launched by Cognizant Communication Corporation as a companion journal to Cell Transplantation. Cell Medicine, an online-only, open access journal, publishes research papers that promise to have direct clinical relevance. The journal is freely accessible at: http://www.ingentaconnect.com/content/cog/cm.

30 Aug 2010

23rd ECNP Press conference on impact of circadian rhythms on human brain

All humans are synchronised to the rhythmic light-dark changes that occur on a daily basis. Rhythms in physiological and biochemical processes and behavioural patterns persist in the absence of all external 24-hour signals from the physical environment, with a period that is close to 24 hours

30 Aug 2010

Researcher develops new plaque brachytherapy technique to treat eye cancer

Rare but devastating, eye cancer can strike anyone at any time and treating it often requires radiation that leaves half of all patients partially blind.But a new technique developed by Scott Oliver, MD, assistant professor at the University of Colorado School of Medicine, may change all that.

30 Aug 2010

Edwards uses his hands after double hand transplant at Jewish Hospital Hand Care Center

Dr. Richard "Rich" Edwards got a look at his new hands for the first time today when all the bandages were removed so doctors could evaluate how the hands are doing. A team of surgeons from Kleinert Kutz and Associates and the University of Louisville performed a double hand transplant on the Oklahoma resident during a 17 ½ hour surgical procedure beginning August 24 at the Jewish Hospital Hand Care Center.

30 Aug 2010

Study finds BMI, thrombogenic factor increases cardiovascular risk

Although having a high body mass index (BMI) is a known risk factor for cardiovascular disease, researchers are only beginning to understand how BMI affects the physiological processes involved in the development of the disease. Now, a study of a subset of women in the Kronos Early Estrogen Prevention Study (KEEPS), suggests that as BMI increases, so do platelet reactivity and thrombogenic microvesicles and activated protein C in the blood-all of which contribute to the formation of atherothrombosis and associated cardiovascular events.

30 Aug 2010

Coke employees protest cancellation of employee health benefits without prior notification

Striking Coke employees and supporters will converge on the Sounders game at Qwest field on Saturday to inform fans about Coke's attack on employee health care. Coke cancelled health care for 500 of its employees without prior notification, after employees went on strike over the Company's refusal to bargain in good faith.

27 Aug 2010

David Mosser to discuss primary duty of macrophages at American Physiological Society conference

The term "macrophage" conjures images of a hungry white blood cell gobbling invading bacteria. However, macrophages do much more than that. Not only do they act as antimicrobial warriors, they also play critical roles in immune regulation and wound-healing. They can respond to a variety of cellular signals and change their physiology in response to local cues.

27 Aug 2010

Second-hand smoke triggers complex inflammatory response

Second-hand smoke is associated with a number of diseases and conditions, including cancer, heart disease, and emphysema. It is an irritant to lung tissue and blood vessels, but the processes through which the body reacts to second-hand smoke comprise a mystery scientists are only beginning to unravel. Researchers at the University of Colorado-Denver are currently studying how second-hand smoke affects the lungs of rats, and so far it appears that second-hand smoke triggers a complex inflammatory response.

27 Aug 2010

JVIR supplement to review thermal ablation usage in treating cancer

The unprecedented growth and promise of using thermal ablation to target and kill cancer is the subject of the Journal of Vascular and Interventional Radiology's August supplement, "Thermal Ablation 2010 At the Crossroads of Past Success, Current Goals and Future Technology."

27 Aug 2010

Disulfiram drug effective in treating cocaine addiction: Research

Doctors have used the drug disulfiram to help patients stay sober for several decades. It interferes with the body's ability to metabolize alcohol, giving a fierce hangover to someone who consumes even a small amount of alcohol.More recently, disulfiram was shown to be effective in treating cocaine addiction as well, even though alcohol and cocaine affect the nervous system in different ways.

27 Aug 2010

FDA denies accelerated approval of Genentech's trastuzumab-DM1 (T-DM1) BLA for metastatic breast cancer

In its review of the BLA, the FDA stated the T-DM1 trials did not meet the standard for accelerated approval because all available treatment choices approved for metastatic breast cancer, regardless of HER2 status, had not been exhausted in the study population.

27 Aug 2010

China PharmaHub signs distribution agreement for radioactive glass sphere treatment for liver cancer

China PharmaHub Corp. ("PharmaHub"), which has recently merged with World Wide Relics which has changed its name to China PharmaHub Corp, and is in the process of obtaining approval from FINRA to trade under its new name with a new symbol, announced today that it has signed an Exclusive Distribution Agreement ("Agreement") with a world leader in precision glass technology which can be utilized to manufacture high precision radioactive glass spheres that emit alpha, beta or gamma radiation, either individually or in combination, for the treatment of malignant tumors of the liver.

26 Aug 2010

Amneal Pharmaceuticals receives FDA approval for Spironolactone HCl tablets

Amneal Pharmaceuticals, LLC is pleased to announce that it has received U.S. FDA approval to manufacture Spironolactone HCl tablets in 25 mg, 50 mg and 100 mg strengths effective July 2, 2010.

26 Aug 2010

Liver News and Research

Mipomersen Phase 3 trial in heFH meets primary, secondary and tertiary endpoints

Pfizer enters agreement to acquire FoldRx Pharmaceuticals

Beaumont Hospital expands new multi-organ transplant program

Leon-Berard Cancer Center to install CyberKnife VSI System

Abbott RealTime HBV assay receives marketing approval from FDA

Non-kidney transplant patients likely to undergo kidney transplant prior to dialysis: Study

Phase 3 EINSTEIN-DVT clinical trial data can transform deep vein thrombosis treatment

Cognizant Communication launches 'Cell Medicine' open access journal

23rd ECNP Press conference on impact of circadian rhythms on human brain

Researcher develops new plaque brachytherapy technique to treat eye cancer

Edwards uses his hands after double hand transplant at Jewish Hospital Hand Care Center

Study finds BMI, thrombogenic factor increases cardiovascular risk

Coke employees protest cancellation of employee health benefits without prior notification

David Mosser to discuss primary duty of macrophages at American Physiological Society conference

Second-hand smoke triggers complex inflammatory response

JVIR supplement to review thermal ablation usage in treating cancer

Disulfiram drug effective in treating cocaine addiction: Research

FDA denies accelerated approval of Genentech's trastuzumab-DM1 (T-DM1) BLA for metastatic breast cancer

China PharmaHub signs distribution agreement for radioactive glass sphere treatment for liver cancer

Amneal Pharmaceuticals receives FDA approval for Spironolactone HCl tablets

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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