Liver News and Research

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Report on unexplained liver haemorrhage after metastasis radiofrequency ablation published

Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation.

19 Nov 2009

Reduction of serum bilirubin, the hallmark of successful biliary drainage

Biliary drainage is performed as a palliative treatment of hilar cholangiocarcinoma. The reduction of serum bilirubin is usually the hallmark of successful biliary drainage. However, some patients may have persistent jaundice or scanty bile output after biliary drainage.

19 Nov 2009

FDA: Plavix-Prilosec combination may reduce anti-clotting effect

Patients should avoid using the stomach acid reducer Prilosec/Prilosec OTC (omeprazole) with the anti-clotting drug Plavix (clopidogrel), the U.S. Food and Drug Administration warned on Nov. 17.

19 Nov 2009

Chronic hepatitis B seems to progress faster in men, report scientists

Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication.

19 Nov 2009

Green tea prevents the development of hepatic fibrosis in rat model of DMN-induced liver fibrosis

Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied.

18 Nov 2009

Lee's Pharmaceutical granted exclusive license to Jennerex' lead product for HCC

Jennerex, Inc., a clinical-stage biotherapeutics company developing a proprietary breakthrough class of targeted oncolytic virus therapeutics, today announced in conjunction with Lee's Pharmaceutical Holdings, the execution of a collaboration and license agreement for Jennerex's lead product candidate, JX-594, in certain Asian territories.

18 Nov 2009

New pre-clinical data from Alnylam Pharmaceuticals' ALN-VSP program presented

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, today announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass.

18 Nov 2009

Press conference highlights emerging treatments in pancreatic cancer

As part of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Thompson will moderate a press conference on emerging treatments in pancreatic cancer on Tuesday, Nov. 17, 2009, in Room 202 of the Hynes Convention Center in Boston, Mass., from 1:00 p.m. to 2:00 p.m. ET.

18 Nov 2009

Maternal blood biomarkers may help predict pregnancy-induced hypertension

A new study that examines the value of maternal blood biomarkers will help identify and monitor patients at risk of developing preeclampsia and is set to change the way expectant mothers are cared for in prenatal clinics around the world.

18 Nov 2009

Almost half of the women in the UK suffer from lack of vitamin A, find scientists

Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found.

18 Nov 2009

Bayer's NEXAVAR approved in over 70 countries for the treatment of liver cancer

Bayer Inc. announced today that its international trial known as SHARP (Sorafenib HCC Assessment Randomized Protocol), led by Study Manager and Bayer Canada employee Tom Giannaris, has been selected as the winner in the 'Best International Trial' category for the Global Clinical Practice Journal Awards.

17 Nov 2009

Upsher-Smith Laboratories publishes results of SLIM Study

Results of the SLIM Study ("Slo-Niacin® and Atorvastatin Treatment of Lipoproteins and Inflammatory Markers in Combined Hyperlipidemia") were recently published in the Journal of Clinical Lipidology.

17 Nov 2009

GE Healthcare announces results from ongoing evaluation of Gemstone Spectral Imaging

GE Healthcare today announced results from its ongoing customer evaluation of Gemstone Spectral Imaging, a technology aiming to enhance CT’s diagnostic capability. Gemstone Spectral Imaging is an available option for Discovery CT750HD systems and is being delivered to customers worldwide.

17 Nov 2009

Additional data from Aegerion Pharmaceuticals' ongoing lomitapide Phase III trial

Aegerion Pharmaceuticals, Inc., a biopharmaceutical company focused on the treatment of cardiovascular and metabolic disease, today announced additional data from its ongoing Phase III trial involving its lead cholesterol management compound, lomitapide (AEGR-733), which is a microsomal triglyceride transfer protein (MTP) inhibitor small molecule drug.

16 Nov 2009

4SC raises funds for further development of its current product pipeline

4SC AG, a drug discovery and development company, today announced the successful completion of a capital increase, after the Management Board, with the approval of the Supervisory Board, passed a resolution to authorise an increase of share capital on 23 October, 2009.

16 Nov 2009

RXi Pharmaceuticals announces financial results for the quarter ended September 30, 2009

RXi Pharmaceuticals Corporation, a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today reported its financial results for the quarter ended September 30, 2009.

16 Nov 2009

Tips to ensure adequate vitamin D levels

Thousands of independent studies in the past three years have revealed a strong connection between vitamin D deficiency and increased risk for a variety of serious illnesses including as many as 22 forms of cancer, heart disease, diabetes, osteoporosis and multiple sclerosis, as well as common colds and flus.

16 Nov 2009

Source of arsenic contamination of drinking water in Bangladesh found by MIT researchers

Researchers in MIT's Department of Civil and Environmental Engineering believe they have pinpointed a pathway by which arsenic may be contaminating the drinking water in Bangladesh, a phenomenon that has puzzled scientists, world health agencies and the Bangladeshi government for nearly 30 years. The research suggests that human alteration to the landscape, the construction of villages with ponds, and the adoption of irrigated agriculture are responsible for the current pattern of arsenic concentration underground.

16 Nov 2009

Decreased heart functions associated with fat collection in different body locations: Study

Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions. The study, which appears on-line in Obesity, also found that measuring a person's body mass index (BMI) does not reliably predict the amount of undesired fat in and around these vital organs.

13 Nov 2009

Amorfix Life Sciences reports operating results for the three months ended September 30, 2009

Amorfix Life Sciences, a company focused on misfolded protein diseases, today reported its second quarter operating results and provided an update on the Company's diagnostic and therapeutic programs.

13 Nov 2009

Liver News and Research

Report on unexplained liver haemorrhage after metastasis radiofrequency ablation published

Reduction of serum bilirubin, the hallmark of successful biliary drainage

FDA: Plavix-Prilosec combination may reduce anti-clotting effect

Chronic hepatitis B seems to progress faster in men, report scientists

Green tea prevents the development of hepatic fibrosis in rat model of DMN-induced liver fibrosis

Lee's Pharmaceutical granted exclusive license to Jennerex' lead product for HCC

New pre-clinical data from Alnylam Pharmaceuticals' ALN-VSP program presented

Press conference highlights emerging treatments in pancreatic cancer

Maternal blood biomarkers may help predict pregnancy-induced hypertension

Almost half of the women in the UK suffer from lack of vitamin A, find scientists

Bayer's NEXAVAR approved in over 70 countries for the treatment of liver cancer

Upsher-Smith Laboratories publishes results of SLIM Study

GE Healthcare announces results from ongoing evaluation of Gemstone Spectral Imaging

Additional data from Aegerion Pharmaceuticals' ongoing lomitapide Phase III trial

4SC raises funds for further development of its current product pipeline

RXi Pharmaceuticals announces financial results for the quarter ended September 30, 2009

Tips to ensure adequate vitamin D levels

Source of arsenic contamination of drinking water in Bangladesh found by MIT researchers

Decreased heart functions associated with fat collection in different body locations: Study

Amorfix Life Sciences reports operating results for the three months ended September 30, 2009

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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