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New cortex organoids more accurately represent the human brain

Essential features of the cortex, an important part of the human brain and its development, are more accurately captured in organoids generated by researchers of the Princess Máxima Center for pediatric oncology and the Hubrecht Institute.

28 Nov 2023

RNA-based therapy shows promise for treating leukemia in animal models

Each year, about 13,000 people in Deutschland are diagnosed with leukemia, an umbrella term that encompasses various forms of blood cancer.

27 Nov 2023

JMU Würzburg professor wins ERC Consolidator Grant to advance research on ferroptosis

With the coveted Consolidator Grants totalling two million euros, the European Research Council (ERC) supports outstanding scientists whose work promises further top achievements. José Pedro Friedmann Angeli, Professor of Translational Cell Biology at Rudolf Virchow Centre - Centre for Integrative and Translational Bioimaging at Julius-Maximilians-Universität (JMU) Würzburg, now belongs to this group.

23 Nov 2023

Breakthrough AI tool PANDA shows promise in early detection of pancreatic cancer using non-contrast CT

A deep learning-based approach to use non-contrast computed tomography (CT) scans for high-accuracy detection and classification of pancreatic lesions.

23 Nov 2023

Genetic vulnerability of leukemia cells uncovered

Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action.

22 Nov 2023

Gene splicing determines CD20 levels and response to monoclonal antibody therapy

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated.

16 Nov 2023

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

Study demonstrates the use of cellulose nanofiber sheets for spatial analysis of extracellular vesicles, revealing their geographical heterogeneity in the human body, which could advance the understanding and treatment of diseases.

14 Nov 2023

Study shows linear associations between body mass index and site-specific tumors in young males

The associations between body mass index (BMI) among young males and new-onset site-specific tumors.

8 Nov 2023

CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus

New research at ACR Convergence 2023, the American College of Rheumatology's annual meeting, demonstrates that CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus while maintaining a robust response to vaccines.

7 Nov 2023

High BMI in late teens linked to higher risk of 17 different cancers later in life

Men who are overweight or obese at age 18 have a higher risk of 17 different cancers later in life. This has been shown in a study at the University of Gothenburg.

6 Nov 2023

Atlas of cancer's hidden rules: Unveiling the transcriptomic and epigenetic secrets across 11 tumors

Researchers have mapped the complex epigenetic and transcriptomic landscape of cancer, revealing key regulatory elements across 11 tumor types that could unlock new insights into cancer progression and metastasis.

5 Nov 2023

Using ripretinib and surgery to manage recurrent gastrointestinal stromal tumor

A new case report was published in Oncoscience (Volume 10) on September 20, 2023, entitled, "Multi-disciplinary management of recurrent gastrointestinal stromal tumor harboring KIT exon 11 mutation with the switch-control kinase inhibitor ripretinib and surgery."

3 Nov 2023

Cancer neuroscience: A new frontier in cancer treatment

Cancer cells hijack normal biological processes, allowing them to multiply. For example, tumors spur construction of new blood vessels, building themselves "highways" to supply nutrients.

1 Nov 2023

New drug shows promise in killing cancer cells with genetic vulnerability

Imagine the body's cells are well-behaved students in the classroom. The "teachers" are tumor suppressor genes, and they make sure cells follow the rules. But when tumor suppressor genes are away, cells may go astray.

1 Nov 2023

Study uncovers interplay of lifestyle choices and DNA methylation in gastric neoplasia risk

A new paper in The Lancet eBioMedicine explores whether these changes predict the future risk of stomach tumors and how epigenetic changes interact with environmental and lifestyle factors in this process.

30 Oct 2023

Rise in skin cancer cases underscores importance of early detection using machine learning

Image-processing techniques in machine learning (ML) for skin cancer detection using clinical images.

30 Oct 2023

In acute myocardial infarction patients, does adding a traditional Chinese medicine compound to standard treatments improve outcomes?

Researchers investigated whether Tongxinluo, a Chinese medicinal compound, could improve clinical outcomes among ST-segment elevation myocardial infarction patients.

26 Oct 2023

Could the microbiome hold the key to diagnosing and treating biliary tract cancer?

A recent study in "Microorganisms" delves into the relationship between the microbiome and biliary tract cancer, revealing distinct microbial compositions in patients compared to healthy individuals. This research highlights potential diagnostic biomarkers and suggests that altering gut microbial composition might enhance responses to cancer immunotherapy.

24 Oct 2023

AI-assisted smartphone app performs well in skin cancer diagnosis

Artificial intelligence (AI) is already widely used in medical diagnostics. An Austrian-Australian research team led by dermatologist Harald Kittler from MedUni Vienna investigated the extent to which diagnosis and therapy of pigmented skin lesions benefit from it in a realistic clinical scenario.