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Young mental health patients at risk from drug interactions

A new study reveals that young patients treated with psychiatric medications receive potentially dangerous combinations with concerning frequency.

6 Sep 2024

Aficamten improves exercise tolerance in patients with HOCM

Exercise intolerance is often severe among patients with cardiovascular disease and can impose significant limitations on their physical abilities and quality of life. Medications known as cardiac myosin inhibitors (CMIs) are being developed to help patients with hypertrophic obstructive cardiomyopathy (HOCM), a disease in which the heart muscle becomes thickened leading to reduced blood flow out of the heart.

5 Sep 2024

Promising new strategy to combat fungal infections

A group of Brazilian researchers has found a potential target for novel therapeutic strategies to combat fungal infections – more specifically, those caused by Aspergillus fumigatus. An article reporting the discovery is published in the journal Communications Biology.

5 Sep 2024

Obesity identified as a significant risk factor for COVID-19 infection

A new study by investigators from Mass General Brigham has found that obesity may be an important risk factor for infection from the virus that causes COVID-19.

4 Sep 2024

Rising injury-related mortality rates among U.S. children and adolescents

Injury-related mortality rates, including firearm-related deaths, among children and adolescents increased in almost every state between 2018-2022, according to findings from the University of Michigan.

4 Sep 2024

Study reassures patients about semaglutide safety

Taking the weight loss medication semaglutide did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior in persons without known major mental health disorders, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania published this week in JAMA Internal Medicine.

4 Sep 2024

Inaccurate data stalls pediatric equity initiatives

Leaders at three Michigan hospitals aiming to address equity issues for pediatric patients wanted to start with inspecting data key to identifying potential inequities.

3 Sep 2024

Maternal fish consumption linked to lower likelihood of autism diagnosis, study finds

Eating any amount of fish during pregnancy was associated with about a 20% lower likelihood of autism spectrum disorder (ASD) diagnosis, particularly in females, and a slight reduction in autism-related traits in offspring, according to a new study funded by the Environmental influences on Child Health Outcomes (ECHO) Program at the National Institutes of Health.

3 Sep 2024

RNA Therapeutics Core launches at Mass General Brigham to boost circular RNA research

The Mass General Brigham Gene and Cell Therapy Institute (GCTI) today announced it has launched the RNA Therapeutics Core, a first-of-its-kind, state-of-the-art facility and resource to advance the use of RNA technologies within and beyond the Mass General Brigham research ecosystem.

3 Sep 2024

Pooled analysis shows finerenone reduces all-cause mortality but not cardiovascular death

A pooled analysis of three large trials failed to demonstrate significant reductions in cardiovascular death with finerenone, but significantly lower all-cause mortality, cardiovascular events and kidney outcomes were observed, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

Study reveals key genetic markers for early onset bicuspid aortic valve complications

Genetic variants linked to a rare form of bicuspid aortic valve disease that affects young adults and can lead to dangerous and potentially life-threatening aortic complications have been identified by researchers at UTHealth Houston.

2 Sep 2024

$Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction$

Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction

Finerenone reduced the composite of total first and recurrent heart failure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial led by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system.

2 Sep 2024

New study confirms safety of SGLT2 inhibitors after acute myocardial infarction

The SGLT2 inhibitor empagliflozin confers kidney-protective benefits and can therefore be given safely and effectively to patients when they are hospitalized for acute myocardial infarction (MI), a Mount Sinai-led global team of researchers has shown.

1 Sep 2024

Semaglutide cuts death rates from cardiovascular disease and COVID-19

Patients taking semaglutide injections are less likely to die of any cause, including from cardiovascular disease and infections like COVID-19, an international study led by researchers from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, finds.

30 Aug 2024

Medicare Advantage enrollment does not affect frailty trajectories

Enrollment in Medicare Advantage (MA) plans is not associated with altered frailty trajectories compared with enrollment in Traditional Medicare (TM), according to research published today in JAMA Network Open.

30 Aug 2024

New ESC guidelines highlight broader approach to managing chronic coronary syndromes

The 2024 ESC Guidelines on the management of chronic coronary syndromes (CCS) include a focus on both larger and smaller blood vessels of the heart; new models to estimate chances of blocked large arteries (so-called obstructive coronary artery disease); optimal selection and sequence of tests; drugs and interventions to prevent disease complications and improve symptoms, and the fundamental role of patient involvement.

30 Aug 2024

Semaglutide lowers COVID-19-related deaths in cardiovascular patients with obesity

Semaglutide, the popular anti-obesity drug, reduced the rates of COVID-19-related adverse events, including death, in those who had overweight or obesity and established cardiovascular disease without diabetes, according to a new study published in JACC, the flagship journal of the American College of Cardiology.

30 Aug 2024

Medical School News and Research

Young mental health patients at risk from drug interactions

Aficamten improves exercise tolerance in patients with HOCM

Promising new strategy to combat fungal infections

Obesity identified as a significant risk factor for COVID-19 infection

Rising injury-related mortality rates among U.S. children and adolescents

Study reassures patients about semaglutide safety

Inaccurate data stalls pediatric equity initiatives

Maternal fish consumption linked to lower likelihood of autism diagnosis, study finds

RNA Therapeutics Core launches at Mass General Brigham to boost circular RNA research

Pooled analysis shows finerenone reduces all-cause mortality but not cardiovascular death

Study reveals key genetic markers for early onset bicuspid aortic valve complications

Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction

New study confirms safety of SGLT2 inhibitors after acute myocardial infarction

Semaglutide cuts death rates from cardiovascular disease and COVID-19

Medicare Advantage enrollment does not affect frailty trajectories

New ESC guidelines highlight broader approach to managing chronic coronary syndromes

Semaglutide lowers COVID-19-related deaths in cardiovascular patients with obesity

UTHealth Houston and Baylor partner to establish Texas's first Injury Control Research Center

Introducing a blood-based test for minimally invasive detection of IDH1 mutant gliomas

New consensus on assessing carcinogenic risks of gene therapies

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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