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Mathematical model predicts lifespan of stem cells

When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed when a patient is low on red blood cells, as in anemia, or white blood cells, which can be caused by cancer or even cancer treatments such as irradiation or chemotherapy. The problem is that a bone marrow transplant might not succeed because the transplanted stem cells don't live long enough or because they proliferate too well, leading to leukemia.

2 Mar 2011

Scientists discover signaling pathway in brain to induce cellular leptin resistance

Researchers at UT Southwestern Medical Center have identified a signaling pathway in the brain that's sufficient to induce cellular leptin resistance, a problem that decreases the body's ability to "hear" that it is full and should stop eating.

2 Mar 2011

Physician administered preventive dental program reduces tooth decay treatment among young children

A preventive dental program targeting preschoolers under age 4 administered by physicians instead of dentists effectively reduces the need for tooth decay-related treatment among young children, a University of North Carolina at Chapel Hill study shows.

2 Mar 2011

Scientists at retrovirus conference present findings on microbicide gel, Truvada, male circumcision, ART care by nurses

At the annual Conference on Retroviruses and Opportunistic Infections (CROI) in Boston on Monday, researchers "suggested the potential" of a gel containing the antiretroviral drug tenofovir to reduce the risk of anal HIV transmission, TIME's "Healthland" blog reports.

2 Mar 2011

Research: Tanning bed exposure can lead to serious skin problems

Tanning bed exposure can produce more than some tanners may bargain for, especially when they self-diagnose and use the radiation to treat skin eruptions, according to research conducted by the Indiana University School of Medicine Department of Dermatology.

2 Mar 2011

Vaccine-induced cellular immune responses against HIV-1 infection exert selective pressure on the virus

An AIDS vaccine tested in people, but found to be ineffective, influenced the genetic makeup of the virus that slipped past. The findings suggest new ideas for developing HIV vaccines.

2 Mar 2011

Sleep loss have negative impact on neurobehavioral functioning in children with ADHD

A new study in the March 1 issue of the journal Sleep indicates that the ability of children with attention deficit hyperactivity disorder to remain vigilant and attentive deteriorated significantly after losing less than one hour of nightly sleep for a week.

2 Mar 2011

Genetic switch increases blood vessels in skeletal muscle of non-exercising mice

Many people suffer from a devastating condition known as critical limb ischemia (CLI) that can lead to muscle wasting and even amputation. The disease is linked to the blockage of blood flow to the skeletal muscle and current treatment options include rehabilitative exercise and surgical bypass of blood vessels. New preclinical research suggests there may be a way to restore blood supply in skeletal muscle without traditional intervention.

2 Mar 2011

Experimental drug may help preserve neurological function in survivors of sudden cardiac arrest

An experimental drug that targets a brain system that controls inflammation might help preserve neurological function in people who survive sudden cardiac arrest, new research suggests.

2 Mar 2011

Government Department of BIS awards £28.5 million to UK-wide study of babies and young children

The largest ever UK-wide study of babies and young children today received a landmark £28.5 million commitment from the Government Department of Business Innovation and Skills.

2 Mar 2011

Bone marrow stem cell transplantation feasible, safe treatment for children with severe traumatic brain injury

For children with severe traumatic brain injury (TBI), transplantation of stem cells derived from the patients' own bone marrow is a "logistically feasible and safe" treatment procedure, reports the March issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

2 Mar 2011

NCI sponsors multi-center phase 2 study of entinostat-anastrozole combination in triple negative breast cancer

Syndax Pharmaceuticals, a clinical-stage epigenetics oncology company, announced the National Cancer Institute (NCI) will sponsor a multi-center phase 2 study of Syndax's lead product entinostat, a novel inhibitor of histone deacetylases (HDAC), and anastrozole, an aromatase inhibitor, in postmenopausal women with operable triple negative breast cancer to evaluate biomarkers and surrogates for response.

2 Mar 2011

OneWorld Health receives FDA clearance for iOWH032 phase 1 trials to treat secretory diarrhea

The Institute for OneWorld Health (iOWH) announced a major milestone in the fight against cholera. The Food and Drug Administration (FDA) granted iOWH permission to begin phase 1 trials for iOWH032, a drug to treat secretory diarrhea. This is the first submission of an Investigational New Drug application for a completely new chemical entity by a non-profit of this size to receive such rapid FDA clearance, and it could be the first synthetic drug of its kind for diarrheal diseases.

2 Mar 2011

Researchers discover three genes that contribute to abnormal growth

By working with Canadians of French ancestry who suffer a rare genetic disease, researchers have discovered how three genes contribute to abnormal growth, making a breakthrough that will improve our understanding of many disorders such as foetal and childhood growth retardation, abnormal development of body parts and cancer.

2 Mar 2011

Regular exercise cuts risk of bowel cancer

People with an active lifestyle are up to three times less likely to develop large or advanced polyps in the bowel - which can develop into bowel cancer - according to a new analysis published in the British Journal of Cancer today (Wednesday).

1 Mar 2011

New CPR method improves long-term survival rates in patients with cardiac arrest by 50%

A five-year clinical trial led by University of Minnesota Medical School researchers has led to a new method of cardiopulmonary resuscitation that improves long-term survival rates with good brain function by 50 percent.

1 Mar 2011

New study: Enzyme that metabolizes vitamin D can predict lung cancer survival

Recent research suggests vitamin D may be able to stop or prevent cancer. Now, a new study finds an enzyme that plays a role in metabolizing vitamin D can predict lung cancer survival.

1 Mar 2011

High blood pressure medications useful even in those without hypertension: Study

Researchers have studied existing evidence to suggest that people who have had a stroke or a heart attack might benefit from taking blood pressure medications, even if they do not have high blood. They noted that for every 1,000 people taking the drugs in clinical trials, on average 15 fewer died from heart disease than when the patients got dummy treatment. The study however could not explain the cause for this benefit. The study, which was funded by Tulane University and the National Institutes of Health, was published in the March 2 issue of the Journal of the American Medical Association.

1 Mar 2011

Think positive for a healthy heart: Study

Researchers suggest that heart disease patients are more likely to survive if they have a positive outlook. The study was published Feb. 28 in the journal Archives of Internal Medicine.

1 Mar 2011

$1 million USDA grant aims to reduce obesity in preschoolers

The preschool years are a critical period for addressing weight-related behaviors among at-risk groups, say researchers at the University of Illinois at Chicago. Among young children, obesity has tripled since 1980, and the prevalence is highest among black and Hispanic children.

1 Mar 2011

Medicine News and Research

Mathematical model predicts lifespan of stem cells

Scientists discover signaling pathway in brain to induce cellular leptin resistance

Physician administered preventive dental program reduces tooth decay treatment among young children

Scientists at retrovirus conference present findings on microbicide gel, Truvada, male circumcision, ART care by nurses

Research: Tanning bed exposure can lead to serious skin problems

Vaccine-induced cellular immune responses against HIV-1 infection exert selective pressure on the virus

Sleep loss have negative impact on neurobehavioral functioning in children with ADHD

Genetic switch increases blood vessels in skeletal muscle of non-exercising mice

Experimental drug may help preserve neurological function in survivors of sudden cardiac arrest

Government Department of BIS awards £28.5 million to UK-wide study of babies and young children

Bone marrow stem cell transplantation feasible, safe treatment for children with severe traumatic brain injury

NCI sponsors multi-center phase 2 study of entinostat-anastrozole combination in triple negative breast cancer

OneWorld Health receives FDA clearance for iOWH032 phase 1 trials to treat secretory diarrhea

Researchers discover three genes that contribute to abnormal growth

Regular exercise cuts risk of bowel cancer

New CPR method improves long-term survival rates in patients with cardiac arrest by 50%

New study: Enzyme that metabolizes vitamin D can predict lung cancer survival

High blood pressure medications useful even in those without hypertension: Study

Think positive for a healthy heart: Study

$1 million USDA grant aims to reduce obesity in preschoolers

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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