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Creative new therapies for atherosclerotic disease

Patients with a build-up of plaque in arteries in the heart, brain and leg face a high risk of major cardiovascular complications.

14 Mar 2006

Faxing alerts to physicians not enough to improve antidepressant adherence

"Our findings confirm that patient-specific alerts using faxes to physicians are not effective at improving patient adherence to antidepressant therapy in the absence of other complementary, coordinated interventions," said Bambauer.

14 Mar 2006

Valproic acid may help slow the progression of dementia

Researchers have found that a common anticonvulsant drug improved cognitive function and appeared to restore nerve cells in the brains of patients with HIV-related dementia. The results of the Phase I clinical trial are published in the March issue of the scientific journal Neurology.

14 Mar 2006

New device for fixing holes in hearts of young stroke patients

As many as one in four adults is walking around with a "hole" between the upper chambers of the heart. Most of them will never know it.

14 Mar 2006

Diabetics overestimate healthy body weight

Heavier patients with diabetes are more likely to overestimate their "healthiest" body weight compared to those of normal weight, according to a study published in the current issue of Diabetes Care.

14 Mar 2006

Yale researchers identifiy a gene that protects the body against kidney stones

The research identifies a transporter, encoded by the gene, as a potential target for drugs to boost oxalate secretion in the gut and help prevent kidney stones, said Peter Aronson, M.D., professor of internal medicine and physiology and senior author of the research.

14 Mar 2006

Single dose of oral antibiotic azithromycin taken after trichiasis eye surgery prevents recurrence of inturned eyelashes

A Johns Hopkins Medicine study finds that a single dose of the oral antibiotic azithromycin taken after trichiasis eye surgery can reduce the frequency with which eyelashes turn back in and abrade the eye.

14 Mar 2006

Antiretroviral therapy (ART) drugs unlikely to stop HIV spread

Researchers believe antiretroviral therapy (ART) will not be effective in stopping HIV epidemics even if it is made universally available in poorer countries, and that widespread use could even lead to an increase in the numbers infected with HIV.

14 Mar 2006

Intensive cholesterol lowering with a statins can partially reverse the buildup of plaque in the coronary arteries

A study presented at the American College of Cardiology's 55th Annual Scientific Session demonstrates, for the first time, that very intensive cholesterol lowering with a statin drug can regress (partially reverse) the buildup of plaque in the coronary arteries.

14 Mar 2006

Hormone C-type natriuretic peptide protects the heart muscle from thickening abnormally

When the heart is weakened, it tries to compensate for its impaired pumping function through an enlargement of the heart muscle cells. Physicians speak in this case of cardiac hypertrophy, abnormal enlargement of the heart.

13 Mar 2006

Best seller Lipitor shown to improve kidney function

According to drug maker Pfizer it's top selling product worldwide, the cholesterol lowering medication Lipitor (Atorvastatin) has been shown to improve kidney function in patients with heart disease.

13 Mar 2006

Aspirin still the best for reducing the heart attack risk

New research has revealed that the addition of the blood-thinning drug Plavix to a daily dose of aspirin does not lower the risk of death, heart attack or stroke in high-risk patients.

13 Mar 2006

Study reveals mechanisms behind Thiazolidinediones used to treat type 2 diabetes

Thiazolidinediones (TZD's) are drugs commonly prescribed to patients with type 2 diabetes, the most common form of diabetes. Current U.S. Food and Drug Administration-approved agents are known as Actos (pioglitazone) and Avandia (rosiglitazone).

13 Mar 2006

Emergency departments score poorly in child-saving drills

A mock-drill study conducted in a third of North Carolina's hospital emergency departments (EDs) revealed that nearly all failed to properly stabilize seriously injured children during trauma simulations, according to a team of researchers at the Johns Hopkins Children's Center and Duke University Medical Center.

13 Mar 2006

Scientists exploit novel route to reverse enlarged hearts in obese mice

Working on genetically engineered obese mice with seriously thickened hearts, a condition call cardiac hypertrophy, scientists at Johns Hopkins have used a nerve protection and growth factor on the heart to mimic the activity of the brain hormone leptin, dramatically reducing the size of the heart muscle.

13 Mar 2006

Quality medical care should include a patient-centered approach

A study of Mayo Clinic patients has found seven behaviors define the 'ideal' physician and supports an Institute of Medicine recommendation that quality medical care should include a patient-centered approach.

13 Mar 2006

High levels of a salivary protein IL-1-beta associated with increased bone loss

Researchers at the University at Buffalo have identified two components of saliva that may serve as the basis for novel tests to determine the risk for future loss of the bone that holds teeth in place.

13 Mar 2006

Exposure to toxins from hazardous waste sites may be a significant risk factor for developing primary biliary cirrhosis

Published in the March 2006 issue of Hepatology, researchers found significant clusters of the disease near Superfund toxic waste sites (SFS) and that the majority of patients in New York City who need liver transplants because of PBC, reside near SFS.

13 Mar 2006

Elderly people should not be afraid to exercise

Older people generally have to work harder than younger people to walk as fast or do other exercise, but some of the difference may be due to reduced exercise efficiency, which can be reversed with training.

13 Mar 2006

Photodynamic therapy may be an effective treatment for infections of the oral cavity

Researchers found that the bacteria S. mutans, as well as fungal organisms of the genus Candida, cultured from HIV patients, were highly susceptible to killing with minimal doses of PDT, both in laboratory dishes and on biofilms grown on denture material.

13 Mar 2006