Metabolites News and Research

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Genetic variation in metabolism identified

Metabolic diseases - in particular the increasingly prevalent type 2 diabetes - are caused by a complex interaction between genetic disposition and unfavorable lifestyle, above all unbalanced diet and too little physical exercise.

30 Nov 2008

Study identifies genetic variants giving rise to differences in metabolism

Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a paper published November 28 in the open-access journal PLoS Genetics.

28 Nov 2008

Researchers discover that a lipid produced in the gut rises after eating fatty foods

As you gorge on food this holiday season, you might not want to think about the fat content of all the goodies you've indulged in.

26 Nov 2008

Wide variability in rheumatoid arthritis drug Methotrexate suggests alternative dosing should be considered

Methotrexate (MTX) is commonly used to treat rheumatoid arthritis (RA) and is suggested as the "anchor" drug in treating the disease.

5 Nov 2008

Fatty acids may be the culprit in Alzheimer's

According to new research from the U.S. controlling the level of a fatty acid in the brain could help treat Alzheimer's disease (AD).

21 Oct 2008

Birth control has long term effect on hormone exposure

Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life.

20 Oct 2008

New technique in blood analysis may speed diagnosis of heart attacks

Someday doctors may be able to use a blood test to confirm within minutes, instead of hours, if a patient is having a heart attack, allowing more rapid treatment that could limit damage to heart muscle.

9 Sep 2008

A fitness test for DNA

Unusually high levels of physical exertion do cause oxidative stress, but this does not result in any long-term damage to DNA. This is just one of the many outcomes revealed by an extraordinary research project funded by the Austrian Science Fund FWF that are now published. As part of this project, 42 male athletes took part both in a triathlon and an extensive biomedical study, which examined numerous physiological values parameters during the period from two days before to 19 days after the triathlon.

21 Aug 2008

Researchers uncover attack mechanism of illness-inducing bacterium found in shellfish

An infectious ocean-dwelling bacterium found in oysters and other shellfish kills its host's cells by causing them to burst, providing the invader with a nutrient-rich meal, researchers at UT Southwestern Medical Center have found.

18 Aug 2008

Human brains pay a price for being big

Metabolic changes responsible for the evolution of our unique cognitive abilities indicate that the brain may have been pushed to the limit of its capabilities. Research published today in BioMed Central's open access journal Genome Biology adds weight to the theory that schizophrenia is a costly by-product of human brain evolution.

4 Aug 2008

Experimental drug turns lab mice into long-distance runners

Trying to reap the health benefits of exercise? Forget treadmills and spin classes, researchers at the Salk Institute for Biological Studies may have found a way around the sweat and pain. They identified two signaling pathways that are activated in response to exercise and converge to dramatically increase endurance.

31 Jul 2008

Exposure to PCBs decreases likelihood of giving birth to boys

Women exposed to high levels of PCBs (polychlorinated biphenyls - a group of banned environmental pollutants) are less likely to give birth to male children.

15 Jul 2008

Carbohydrate and caffeine following exhaustive exercise helps muscles refuel

Recipe to recover more quickly from exercise: Finish workout, eat pasta, and wash down with five or six cups of strong coffee.

1 Jul 2008

Novel approach for treating mitochondrial disorders wins Kaye prize

A novel concept for the treatment of mitochondrial disorders using directed enzyme replacement therapy (DERT) has won for a Hebrew University of Jerusalem doctoral candidate one of this year's Kaye Innovation Awards. The awards were presented at this year's 71st meeting of the Hebrew University Board of Governors.

30 Jun 2008

Computer predicts anti-cancer molecules

A new computer-based method of analyzing cellular activity has correctly predicted the anti-tumour activity of several molecules.

16 Jun 2008

Hypertension all about what you eat and drink

Scientific research on human metabolism based on people from around the world has revealed compounds in urine indicate surprising differences affecting blood pressure.

20 Apr 2008

What we eat and drink affects our risk of cancer

A healthy diet and lifestyle protect against a wide range of diseases, and new research presented at the American Association for Cancer Research 2008 Annual Meeting, April 12-16, shows that cancer is no exception.

13 Apr 2008

Biomarkers may reduce the need for biopsies and personalize transplant patient care

Data presented at the 28th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) suggest the potential of a significant impact of using biomarkers to reduce the need for biopsies and personalize transplant patient care.

11 Apr 2008

Rare genetic syndrome may hold key to cure for heat stroke

A genetic disorder that can cause a fatal rise in body temperature in some patients undergoing general anesthesia may hold the key to a cure for heat stroke, according to research published in the April 4 edition of the journal Cell.

4 Apr 2008

Researcher discovers pathway plants use to fight back against pathogens

Plants are not only smart, but they also wage a good fight, according to a University of Missouri biochemist. Previous studies have shown that plants can sense attacks by pathogens and activate their defenses.

1 Apr 2008