Mitochondria News and Research

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Potential biomarker could help prevent pre-diabetic individuals from developing Type II diabetes

Virginia Tech researchers have identified a biomarker in pre-diabetic individuals that could help prevent them from developing Type II diabetes.

21 Aug 2015

Energy-burning 'good' fat helps reduce weight gain, lower blood glucose levels in mice

Scientists at the University of California, Berkeley, have developed a novel way to engineer the growth and expansion of energy-burning "good" fat, and then found that this fat helped reduce weight gain and lower blood glucose levels in mice.

20 Aug 2015

Study suggests potential target for treating familial form of ALS

A healthy motor neuron needs to transport its damaged components from the nerve-muscle connection all the way back to the cell body in the spinal cord. If it cannot, the defective components pile up and the cell becomes sick and dies. Researchers at the NIH's National Institute of Neurological Disorders and Stroke have learned how a mutation in the gene for superoxide dismutase 1 (SOD1), which causes ALS, leads cells to accumulate damaged materials.

13 Aug 2015

Scientists develop biosensor to measure abnormal activity of cell 'fuel' carrier

To be able to function, cell mitochondria import "fuel" using a carrier, the Mitochondrial Pyruvate Carrier (MPC). In order to determine whether the MPC is still functional in malignant cells, the team of Professor Jean-Claude Martinou, at the University of Geneva, Switzerland, has just developed a biosensor to measure its live activity.

7 Aug 2015

Animal study shows children exposed to famine grow smaller, become susceptible to metabolic diseases

Starvation early in life can alter an organism for generations to come, according to a new study in roundworms. The effects are what Duke University biologist Ryan Baugh terms a "bet-hedging strategy."

3 Aug 2015

Balancing cellular aging and cancer risk through biotechnology

In a way, trying to repair age-related heart damage and trying to fight cancer are opposite problems. Your heart cells' ability to regenerate themselves and proliferate into new, young cells degrades as you get older.

30 Jul 2015

New approach holds great promise for developing effective treatments for human mitochondrial diseases

Using existing drugs, such as lithium, to restore basic biological processes in human cells and animal models, researchers may have broken a long-standing logjam in devising effective treatments for human mitochondrial diseases.

21 Jul 2015

New research offers potential for early intervention to prevent neurodegenerative diseases

New research led by investigators at Beth Israel Deaconess Medical Center provides the first direct evidence linking traumatic brain injury to Alzheimer's disease and chronic traumatic encephalopathy (CTE) -- and offers the potential for early intervention to prevent the development of these debilitating neurodegenerative diseases.

16 Jul 2015

Research breakthrough opens door to a world of regenerative medicine for treating mitochondrial disease

A study led by Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy at Oregon Health & Science University and the Oregon National Primate Research Center has revealed the first critical step in developing novel gene and stem cell therapy treatments for patients with mitochondrial disease.

16 Jul 2015

Salk researchers move one step closer to making cures for genetic diseases a reality

Healthy brain, muscle, eye and heart cells would improve the lives of tens of thousands of people around the world with debilitating mitochondrial diseases. Now, researchers at the Salk Institute have gotten one step closer to making such cures a reality: they've turned cells from patients into healthy, mutation-free stem cells that can then become any cell type.

16 Jul 2015

UM researchers discover new gene behind neurodegenerative conditions

Researchers at the University of Miami have discovered and characterized a previously unknown disease gene linked to the degeneration of optic and peripheral nerve fibers. The study titled "Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder" is published in the journal Nature Genetics.

14 Jul 2015

Defects in mitochondria play key role in transition of normal cells to cancerous cells

Cancer cells defy the rules by which normal cells abide. They can divide without cease, invade distant tissues and consume glucose at abnormal rates.

9 Jul 2015

Cognizin citicoline shows promise in patients with bipolar disorder and cocaine dependence

The results of a randomized, double-blind, placebo-controlled clinical trial showed that Cognizin citicoline (Jarrow Formulas) was effective at reducing cocaine use, based on urine drug screens, in patients with bipolar disorder and cocaine dependence. The study, published in the American Journal of Psychiatry in Advance, included a total of 130 outpatients with bipolar I disorder and cocaine dependence, who received either Cognizin citicoline or placebo add-on therapy for 12 weeks.

7 Jul 2015

Tests reveal that FY26 cancer drug is 49 times more potent than Cisplatin drug

Tests have shown that a new cancer drug, FY26, is 49 times more potent than the clinically used treatment Cisplatin.

7 Jul 2015

New research suggests that Bcl-Rambo protein can protect against heart failure

A protein dubbed 'Bcl-Rambo' can protect against heart failure, suggests new research from King's College London and funded by the British Heart Foundation.

7 Jul 2015

Dietary fat intake could potentially ease mitochondrial disease, shows research

Mice that have a genetic version of mitochondrial disease can easily be mistaken for much older animals by the time they are nine months old: they have thinning grey hair, osteoporosis, poor hearing, infertility, heart problems and have lost weight. Despite having this disease at birth, these mice have a "secret weapon" in their youth that staves off signs of aging for a time.

1 Jul 2015

Wistar Institute study shows that PI3K inhibitors may make a patient's cancer even worse

The enzyme phosphatidylinositol-3 kinase (PI3K) appears to be exploited in almost every type of human cancer, making it the focus of considerable interest as a therapeutic target, with many PI3K-inhibiting drugs currently in various stages of clinical development. However, PI3K inhibitors have only shown modest clinical activity with patients who receive these drugs experiencing very little improvement in survival.

30 Jun 2015

Retina contains microtubule "roadway" that provides energy required for visual processing

Researchers have discovered a thick band of microtubules in certain neurons in the retina that they believe acts as a transport road for mitochondria that help provide energy required for visual processing.

30 Jun 2015

NGS technology helps identify new mitochondrial disease gene

Next Generation Sequencing (NGS) technology offers an incredible opportunity for the rapid and relatively low-cost characterization of individual genomes, giving us a chance to make a substantial leap ahead in the molecular dissection of all mitochondrial disorders in humans.

27 Jun 2015

Newcastle University scientists document action spectrum of ultraviolet damage in skin cells

Scientists at Newcastle University have documented for the first time the DNA damage which can occur to skin across the full range of ultraviolet radiation from the sun providing an invaluable tool for sun-protection and the manufacturers of sunscreen.

27 Jun 2015

Mitochondria News and Research

Potential biomarker could help prevent pre-diabetic individuals from developing Type II diabetes

Energy-burning 'good' fat helps reduce weight gain, lower blood glucose levels in mice

Study suggests potential target for treating familial form of ALS

Scientists develop biosensor to measure abnormal activity of cell 'fuel' carrier

Animal study shows children exposed to famine grow smaller, become susceptible to metabolic diseases

Balancing cellular aging and cancer risk through biotechnology

New approach holds great promise for developing effective treatments for human mitochondrial diseases

New research offers potential for early intervention to prevent neurodegenerative diseases

Research breakthrough opens door to a world of regenerative medicine for treating mitochondrial disease

Salk researchers move one step closer to making cures for genetic diseases a reality

UM researchers discover new gene behind neurodegenerative conditions

Defects in mitochondria play key role in transition of normal cells to cancerous cells

Cognizin citicoline shows promise in patients with bipolar disorder and cocaine dependence

Tests reveal that FY26 cancer drug is 49 times more potent than Cisplatin drug

New research suggests that Bcl-Rambo protein can protect against heart failure

Dietary fat intake could potentially ease mitochondrial disease, shows research

Wistar Institute study shows that PI3K inhibitors may make a patient's cancer even worse

Retina contains microtubule "roadway" that provides energy required for visual processing

NGS technology helps identify new mitochondrial disease gene

Newcastle University scientists document action spectrum of ultraviolet damage in skin cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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