Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.
Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

Basigin does not facilitate SARS-CoV-2 entry, say researchers

Basigin does not facilitate SARS-CoV-2 entry, say researchers

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

Current monoclonal antibodies less potent against SARS-CoV-2 variants

Current monoclonal antibodies less potent against SARS-CoV-2 variants

FDA issues guidance for medical product developers to address the emergence of SARS-CoV-2 variants

FDA issues guidance for medical product developers to address the emergence of SARS-CoV-2 variants

Llama-derived nanobodies show neutralizing activity against SARS-CoV-2 variants of concern in vitro

Llama-derived nanobodies show neutralizing activity against SARS-CoV-2 variants of concern in vitro

Rural hospital remains entrenched in Covid ‘war’ even amid vaccine rollout

Rural hospital remains entrenched in Covid ‘war’ even amid vaccine rollout

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

UCI Health creates new system to deliver monoclonal antibodies in COVID-19 patients

UCI Health creates new system to deliver monoclonal antibodies in COVID-19 patients

Bioengineered ankyrin compounds show high in vitro activity against SARS-CoV-2 mutants

Bioengineered ankyrin compounds show high in vitro activity against SARS-CoV-2 mutants

SARS-CoV-2 escape mutations identified against monoclonal antibodies and polyclonal immune sera

SARS-CoV-2 escape mutations identified against monoclonal antibodies and polyclonal immune sera

COVID-19 pandemic and nanotechnology

COVID-19 pandemic and nanotechnology

Pfizer vaccine and Eli Lilly monoclonal antibodies successfully neutralize SARS-CoV-2 UK variant, finds study

Pfizer vaccine and Eli Lilly monoclonal antibodies successfully neutralize SARS-CoV-2 UK variant, finds study

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

LCMC3 trial: Neoadjuvant atezolizumab prior to lung cancer surgery meets primary endpoint

LCMC3 trial: Neoadjuvant atezolizumab prior to lung cancer surgery meets primary endpoint

Study finds protective genetic associations with mild COVID-19

Study finds protective genetic associations with mild COVID-19