Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

Novel monoclonal antibody found to have substantial neutralizing capacity against SARS-CoV-2 Omicron variant

Researchers reported a new monoclonal antibody, P2G3, which significantly neutralized the SARS-CoV-2 Omicron variant.

23 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

Early treatment of COVID-19 in high-risk children and adolescents infected with the Omicron variant of SARS-CoV-2

Researchers discussed patient features, treatment-associated process measures, and outcomes associated with early monoclonal antibody and antiviral therapy in high-risk pediatric patients infected with the SARS-CoV-2 Omicron variant.

22 Mar 2022

Study reveals novel tumor biomarker of aggressive cancers with poor prognosis

A study published in The Journal of Pathology reveals that many cancers that carry a poor prognosis express an altered form of human telomerase reverse transcriptase (hTERT), an enzyme that regulates the expression of multiple genes.

22 Mar 2022

Study explores SARS-CoV-2 spike epitope with potent and broad neutralization

Researchers reported an epitope with high potency and breadth and demonstrated that a therapeutic antibody directed at this site neutralizes all SARS-CoV-2 variants.

18 Mar 2022

It was already hard to find Evusheld, a covid prevention therapy. Now it’s even harder.

As immunocompromised people across the country work to get Evusheld, a potentially lifesaving covid therapy, several hundred providers of the injections were removed from a federal dataset on Wednesday night, making the therapy even harder to locate.

17 Mar 2022

Study evaluates monoclonal antibody treatment for pregnant COVID-19 patients

Researchers evaluated COVID-19 monoclonal antibody treatment in pregnant and postpartum women.

16 Mar 2022

Do anti-nucleocapsid antibodies affect COVID-19 immune reactions?

Researchers have been investigating the potential for vaccines and treatments against the nucleocapsid protein of SARS-CoV-2.

15 Mar 2022

Sino Biological Invests Over 200M RMB to Establish New Subsidiaries in Taizhou and Suzhou, China.

Sino Biological is pleased to announce the formation of two new operationally-focused subsidiaries in China.

From Sino Biological Inc. 14 Mar 2022

Canadian scientist discusses about how society could better prepare for future pandemics

Aled Edwards is of two minds about medicine's response to COVID-19. On one hand, he notes, we had life-saving vaccines and therapies less than a year after the discovery of SARS-CoV-2. On the other, more than six million, and possibly as many as 18 million people have died, and global access to advances that can prevent and treat severe disease remains highly inequitable.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

The new drug nirsevimab showed 74.5 percent efficacy against medically attended lower respiratory tract infections caused by respiratory syncytial virus (RSV) in healthy infants, according to an international, randomized, placebo-controlled phase 3 clinical trial published in the New England Journal of Medicine.

9 Mar 2022

Effectiveness of mRNA vaccines, antibody treatment reduced by all three omicron subvariants

Only one currently authorized antibody treatment retains its activity against all Omicron subvariants, according to new research by scientists at Columbia University and the University of Hong Kong.

3 Mar 2022

Long-acting monoclonal antibody shows potential to offer RSV protection for all infants

Nirsevimab showed 74.5 percent efficacy against medically attended lower respiratory tract infections caused by respiratory syncytial virus (RSV) in healthy infants, according to an international, randomized, placebo-controlled Phase 3 clinical trial.

3 Mar 2022

Intensive treatment for patients with Crohn's disease found to be safe

Intensive treatment for patients with Crohn's disease showed no safety differences compared to the current standard of care, according to a trial published in the journal Gastroenterology.

1 Mar 2022

U of U Health researchers lead a $22-million nationwide clinical trial for rare brain disorder

University of Utah Health researchers are leading a five-year, $22-million nationwide clinical trial for NMDA receptor encephalitis––a type of autoimmune encephalitis that prompts the immune system to mistakenly attack the brain, causing confusion, memory loss, seizures, and symptoms similar to bipolar disorder and other psychiatric conditions.

1 Mar 2022

Study finds MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern in Syrian hamster COVID-19 model

Researchers found that an antiviral drug, was effective against SARS-CoV-2 variants, including the recently emerged Omicron variant, in Syrian hamsters.

1 Mar 2022

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Researchers demonstrated that decorating the capsid surface of adenovirus vaccine vectors with a newly discovered protein superglue, DogTag/DogCatcher generates potent SARS-CoV-2-specific humoral and cellular immunity.

24 Feb 2022

New approach for extensive screening of monoclonal antibody clones against multiple myeloma cells

Multiple myeloma (MM) is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, investigators from Japan have recently found that a common component of amino acid transporters, CD98 heavy chain, represents an effective monoclonal antibody target in treating MM.

22 Feb 2022

Monoclonal Antibody News and Research

Further Reading

Novel monoclonal antibody found to have substantial neutralizing capacity against SARS-CoV-2 Omicron variant

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Early treatment of COVID-19 in high-risk children and adolescents infected with the Omicron variant of SARS-CoV-2

Study reveals novel tumor biomarker of aggressive cancers with poor prognosis

Study explores SARS-CoV-2 spike epitope with potent and broad neutralization

It was already hard to find Evusheld, a covid prevention therapy. Now it’s even harder.

Study evaluates monoclonal antibody treatment for pregnant COVID-19 patients

Do anti-nucleocapsid antibodies affect COVID-19 immune reactions?

Sino Biological Invests Over 200M RMB to Establish New Subsidiaries in Taizhou and Suzhou, China.

Canadian scientist discusses about how society could better prepare for future pandemics

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

Effectiveness of mRNA vaccines, antibody treatment reduced by all three omicron subvariants

Long-acting monoclonal antibody shows potential to offer RSV protection for all infants

Intensive treatment for patients with Crohn's disease found to be safe

U of U Health researchers lead a $22-million nationwide clinical trial for rare brain disorder

Study finds MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern in Syrian hamster COVID-19 model

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

New approach for extensive screening of monoclonal antibody clones against multiple myeloma cells

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