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New partnership to provide access to contraceptives for more than 27M women

A new partnership announced today at the United Nations will make a safe, effective, long-acting, reversible method of contraception available to more than 27 million women in the world's poorest nations.

28 Sep 2012

Elevated c-Myc expression amplifies gene activity in tumor cells of multiple cancer types

For a cancer patient, over-expression of the MYC oncogene is a bad omen. Scientists have long known that in tumor cells, elevated levels of MYC's protein product, c-Myc, are associated with poor clinical outcomes, including increased rates of metastasis, recurrence, and mortality. Yet decades of research producing thousands of scientific papers on the subject have failed to consistently explain precisely how c-Myc exerts its effects across a broad range of cancer types. Until now, that is.

28 Sep 2012

Researchers identify genetic origins in 10% of aortic valve malformations

Researchers at the Sainte-Justine University Hospital Center and University of Montreal have identified genetic origins in 10% of an important form of congenital heart diseases by studying the genetic variability within families.

28 Sep 2012

Incarcerated patients with chronic HCV likely to achieve sustained viral response

Incarcerated patients with chronic hepatitis C virus (HCV) infection are just as likely to respond to treatment for the disease as patients in the community, according to findings published in the October issue of Hepatology, a peer-reviewed journal of the American Association for the Study of Liver Diseases.

28 Sep 2012

Global Strategy for Women's and Children's Health receives $20 billion in new money

The Global Strategy for Women's and Children's Health has received about $20 billion in new money, according to a new report from The Partnership for Maternal, Newborn & Child Health (PMNCH).

28 Sep 2012

U.N. presents plan to improve access to contraception, releases report on maternal, child health

The U.N. on Wednesday "presented a plan to make life-saving health supplies more accessible, while a new report found that, despite impressive reductions in maternal and child mortality in the past decade in some countries, millions of women and children still die every year from preventable causes," the U.N. News Centre reports.

28 Sep 2012

Novel oral anticoagulant bleeding risk offsets clinical benefit

The use of orally activated Xa antagonist and direct thrombin inhibitors is associated with a significant increase in major bleeding events in acute coronary syndrome patients, a study shows.

27 Sep 2012

Postsurgery mortality rates vary across Europe

Europe-wide data suggest that mortality rates after noncardiac surgery are higher than expected, and vary substantially by country, reports an international research team in The Lancet.

27 Sep 2012

Warfarin therapy should not be stopped completely after GI bleeding

The decision to not resume warfarin therapy following a gastrointestinal bleeding event is linked to an increased risk for thrombosis and mortality, researchers suggest.

27 Sep 2012

Enrollment complete in Boehringer Ingelheim’s nintedanib phase III studies for IPF

Boehringer Ingelheim Pharmaceuticals, Inc. announced that clinical trial enrollment has completed for two phase III studies evaluating the safety and efficacy of nintedanib (BIBF 1120), an investigational compound, in patients with idiopathic pulmonary fibrosis (IPF), being studied at a twice-daily oral dose.

27 Sep 2012

Short-course amphotericin is cost-effective for cryptococcal meningitis

The treatment of cryptococcal meningitis in resource-limited settings is most effective with a short 1-week course of amphotericin induction therapy coupled with high-dose fluconazole for at least 2 weeks, a Ugandan study suggests.

26 Sep 2012

Developing world lagging in anesthesia safety

Mortality after general anesthesia has declined over the past 50 years, but the greatest gains have been in developed countries, shows a systematic review in The Lancet.

26 Sep 2012

Women's eNews examines maternal health in Morocco

"Morocco has made great strides in improving maternal health in recent years, decreasing its maternal mortality ratio by over 60 percent since 1990," but "a wide maternal health gap" exists between women in urban and rural areas, where deliveries generally are attended by an experienced yet untrained family member, Women's eNews reports.

26 Sep 2012

PsiOxus initiates ColoAd1 phase I/II trial in metastatic solid tumours

PsiOxus Therapeutics, Ltd. has treated the first patient in its phase I/II clinical trial of ColoAd1for the treatment of metastatic solid tumours.

26 Sep 2012

High concentrations of inhaled oxygen during and after cancer surgery may increase risk of death

Patients given high concentrations of inhaled oxygen during and after cancer surgery may be at higher long-term risk of death, according to a report in the October issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

26 Sep 2012

Flow cytometry isolates stem cells from brain tumors

A new video protocol in Journal of Visualized Experiments (JoVE) details an assay to identify brain tumor initiating stem cells from primary brain tumors. Through flow cytometry, scientists separate stem cells from the rest of the tumor, allowing quick and efficient analysis of target cells. This approach has been effectively used to identify similar stem cells in leukemia patients.

26 Sep 2012

Differences in viral illness patterns play a role in asthma development in urban, suburban children

Children living in low-income urban areas appear especially prone to developing asthma, possibly related to infections they acquire early in life. In a new study in The Journal of Infectious Diseases, available online, researchers from the University of Wisconsin in Madison investigated viral respiratory illnesses and their possible role in the development of asthma in urban versus suburban babies.

26 Sep 2012

Regular mammography screening can help narrow racial gaps in breast cancer outcomes

Regular mammography screening can help narrow the breast cancer gap between black and white women, according to a retrospective study published in Breast Cancer Research and Treatment in August.

26 Sep 2012

Kidney disease linked with risk of death and ESRD even in patients without hypertension or diabetes

Two new studies from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that the presence of chronic kidney disease itself can be a strong indicator of the risk of death and end-stage renal disease (ESRD) even in patients without hypertension or diabetes.

26 Sep 2012

Warfarin therapy should not be stopped completely after GI bleeding

The decision to not resume warfarin therapy following a gastrointestinal bleeding event is linked to an increased risk for thrombosis and mortality, researchers suggest.

25 Sep 2012

Mortality News and Research

New partnership to provide access to contraceptives for more than 27M women

Elevated c-Myc expression amplifies gene activity in tumor cells of multiple cancer types

Researchers identify genetic origins in 10% of aortic valve malformations

Incarcerated patients with chronic HCV likely to achieve sustained viral response

Global Strategy for Women's and Children's Health receives $20 billion in new money

U.N. presents plan to improve access to contraception, releases report on maternal, child health

Novel oral anticoagulant bleeding risk offsets clinical benefit

Postsurgery mortality rates vary across Europe

Warfarin therapy should not be stopped completely after GI bleeding

Enrollment complete in Boehringer Ingelheim’s nintedanib phase III studies for IPF

Short-course amphotericin is cost-effective for cryptococcal meningitis

Developing world lagging in anesthesia safety

Women's eNews examines maternal health in Morocco

PsiOxus initiates ColoAd1 phase I/II trial in metastatic solid tumours

High concentrations of inhaled oxygen during and after cancer surgery may increase risk of death

Flow cytometry isolates stem cells from brain tumors

Differences in viral illness patterns play a role in asthma development in urban, suburban children

Regular mammography screening can help narrow racial gaps in breast cancer outcomes

Kidney disease linked with risk of death and ESRD even in patients without hypertension or diabetes

Warfarin therapy should not be stopped completely after GI bleeding

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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