Mouse Model News and Research

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Scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

Like tuning a violin to produce strong, elegant notes, researchers at The Wistar Institute have found multiple receptors on the outside of the body's killer immune system cells which they believe can be selectively targeted to keep the cells in superb infection- and disease-fighting condition.

30 Nov 2008

Discovery of mechanism linking serotonin with regulation of food intake

Genetic mouse models have provided surprising insight into mechanisms linking serotoninergic compounds with the regulation of feeding behavior and body weight.

26 Nov 2008

Mouse model of prion disease mimics diverse symptoms of human disorder

A comprehensive mouse model of inherited prion disease exhibits cognitive, motor, and neurophysiological deficits that bear a striking resemblance to the symptoms experienced by patients with the human version of "mad cow disease," Creutzfeldt-Jakob disease (CJD).

26 Nov 2008

Researchers find clue to safer obesity drugs

Once hailed as a miracle weight-loss drug, Fen-phen was removed from the market more than a decade ago for inducing life-threatening side effects, including heart valve lesions. Scientists at UT Southwestern Medical Center are trying to understand how Fen-phen behaves in the brain in order to develop safer anti-obesity drugs with fewer side effects.

25 Nov 2008

Scientists develop unlimited pure insulin-producing cells from mouse embryonic stem cells

These pure insulin-producing cells, which according to electron microscopy studies, have the same sub-cellular structures as the insulin-producing cells naturally found in the pancreas, were highly effective in treating diabetes in the mouse model.

20 Nov 2008

Reduced-calories and exercise can modify a postmenopausal woman's risk of breast cancer

Scientists at the University of Texas at Austin have identified pathways by which a reduced-calorie diet and exercise can modify a postmenopausal woman's risk of breast cancer.

18 Nov 2008

Two common cancer drugs prevent, reverse type 1 diabetes

Two common cancer drugs have been shown to both prevent and reverse type 1 diabetes in a mouse model of the disease, according to research conducted at the University of California, San Francisco.

18 Nov 2008

Discovery of unique approach for delivering drugs to the brain - potential for Alzheimer's and stroke

Saint Louis University researchers have identified a novel way of getting a potential treatment for Alzheimer's disease and stroke into the brain where it can do its work.

12 Nov 2008

Hydrogen sulfide could be used to treat humans with heart failure

At low concentrations, the toxic gas hydrogen sulfide protects the hearts of mice from heart failure, scientists at Emory University School of Medicine have found.

12 Nov 2008

Scientists map steps to block enzyme phosphodiesterase 5's action in heart failure

Taking a cue from the way drugs like Viagra put the biological brakes on a key enzyme involved in heart failure, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking the enzyme.

12 Nov 2008

Researchers discover genetic basis for some common congenital birth defects

10 Nov 2008

Absence of ERK2 gene linked to birth defects

A multidisciplinary research team at Case Western Reserve University led by Gary Landreth, Ph.D., a professor in the School of Medicine's Department of Neurosciences, has uncovered a common genetic pathway for a number of birth defects that affect the development of the heart and head. Abnormal development of the jaw, palate, brain and heart are relatively common congenital defects and frequently arise due to genetic errors that affect a key developmental pathway.

10 Nov 2008

Santaris Pharma releases positive data on LNA-based survivin inhibitor

Santaris Pharma announced today that SPC3042, a RNA-based antisense oligonucleotide developed using the company's proprietary Locked Nucleic Acid (LNA) technology, potently blocks survivin, a key survival protein in cancer cells, in both in vitro and in vivo models of prostate cancer. Importantly, SPC3042 works synergistically with the anticancer drug paclitaxel (Taxol) in both model systems.

10 Nov 2008

Gene research sheds light on T-cell production

New research, just published by researchers from the University of Georgia, provides the first evidence that a key gene may be crucial to maintaining the production of the thymus and its disease-fighting T-cells after an animal's birth.

7 Nov 2008

Targeting epigenetic changes helps tackle MLL-AF4 leukemias

A very difficult-to-treat child leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer - but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on.

4 Nov 2008

Adding protein sarcospan to muscle cells might help Duchenne muscular dystrophy

The overlooked and undervalued protein, sarcospan, just got its moment in the spotlight.

4 Nov 2008

Potential therapeutic target for acute leukemia types

Research using a new mouse model has led to the identification of a potential therapeutic target for a type of leukemia commonly associated with an unfavorable prognosis.

4 Nov 2008

Discovery of mechanism and possible drug treatment for growth of nerve tumors in neurofibromatosis

Researchers studying neurofibromatosis type 1 - a rare disease in which tumors grow within nerves - have found that the tumors are triggered by crosstalk between cells in the nerves and cells in the blood.

30 Oct 2008

Cancer requires support from immune system to develop, researchers report

Tumors that grow around nerves in a rare genetic disease need cooperation from cells from the immune system in order to grow, reports a team of scientists, including researchers from UT Southwestern Medical Center.

30 Oct 2008

Near-infrared nanoparticles shine a bright light on cancer

A new nanoparticle-enabled imaging method for breast cancer has been developed by a team of scientists from Penn State. Their research, utilizing encapsulated fluorescent molecules in calcium phosphate nanoparticles and nontoxic near infrared (NIR) imaging, appears in the journal ACS Nano.

27 Oct 2008