Mouse Model News and Research

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Long-term muscle improvements shown in gene therapy study in mice

Injecting a gene responsible for making a specific protein into a mouse that's used as a model for muscular dystrophy can lead to long-term improvements in the animal's muscle size and strength, a new study shows.

14 Mar 2008

Cause of prolonged penile erection

Priapism (prolonged penile erection in the absence of sexual interest) is common in male individuals with sickle cell disease (SCD), a blood disorder characterized by abnormally shaped red blood cells.

14 Mar 2008

New mouse model of bipolar disorder

Bipolar Disorder (BPD or manic-depressive illness) is one of the most serious of all mental disorders, affecting millions of individuals worldwide.

13 Mar 2008

Specialized natural killer cells in human tonsils help protect against Epstein Barr virus

Tonsils are a source of sore throats and an excuse for ice cream. But they also provide an important protective service, their immune-cell-rich tissue acting as the body's first defense against the germs about to be swallowed or inhaled.

12 Mar 2008

Mouse model for human malignant mesothelioma

Scientists have established a mouse model for human malignant mesothelioma (MM) that will provide valuable insight into cancer development and progression along with new directions for design of therapeutic strategies.

11 Mar 2008

Long-term muscle improvements shown in gene therapy study in mice

11 Mar 2008

New potential drug target for atherosclerosis

A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone to developing the harmful plaques, according to new research by scientists at the Salk Institute for Biological Studies and the Harvard School of Public Health.

6 Mar 2008

Prader-Willi syndrome - new genetic clues

A new mouse model for a genetic cause of obesity has been developed by scientists at the Stanford University School of Medicine and Lucile Packard Children's Hospital.

6 Mar 2008

Bardet-Biedl syndrome provides clues on obesity, blood pressure

University of Iowa researchers have found a clue about how resistance to the hormone leptin might disrupt the brain signals that tell the body when to stop eating.

4 Mar 2008

Fluorescent nanoparticles image tumor marker in animals

Since 2004 the U.S. Food and Drug Administration has approved three new-generation anticancer therapies that target epidermal growth factor receptor (EGFR), a protein that is greatly overexpressed on certain types of tumors, including some forms of colorectal and lung cancer.

3 Mar 2008

Kidney stones in men

Kidney stones are very common - and painful - in men. About 3 in 20 men (1 in 20 women) in developed countries develop them at some stage.

3 Mar 2008

Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt

Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at Washington University School of Medicine in St. Louis decided to try to fine-tune the animal models used to test new drugs.

3 Mar 2008

Discovery of family of genes linked to the development of liver cancer

An interdisciplinary team of researchers at Stony Brook University Medical Center has identified a family of genes linked to the development of liver cancer.

28 Feb 2008

Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma

A gene crucial for embryonic development can quickly become a potent cancer promoter in adult mice after a genetic misalignment, according to researchers from Fox Chase Cancer Center, causing white blood cells to become cancerous spontaneously.

28 Feb 2008

Protein that stimulates blood vessel growth worsens ovarian cancer

A protein that stimulates blood vessel growth worsens ovarian cancer, but its production can be stifled by a tiny bit of RNA wrapped in a fatty nanoparticle, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Journal of the National Cancer Institute.

27 Feb 2008