Mouse Model News and Research

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Kidney cancer drug attacks a major type of acute myeloid leukemia

A drug used to treat kidney cancer also targets a genetic mutation active in about one third of patients with acute myeloid leukemia (AML), the most common and lethal form of adult leukemia, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan. 29 edition of the Journal of the National Cancer Institute.

30 Jan 2008

Deafness and seizures result when glutamate protein deleted in mice

Scientists have discovered that mice genetically engineered to lack a particular protein in the brain have profound deafness and seizures.

25 Jan 2008

Brain molecule from endothelial cells may be a new target for treatment of multiple sclerosis

In the February issue of Nature Immunology, the team provides fresh answers concerning the role of novel adhesion molecules in the pathogenesis of MS, a chronic autoimmune disease of the nervous system that affects approximately 55,000 young adults in Canada.

23 Jan 2008

Altering brain's lipid metabolism reduces Alzheimer's plaques in mice

Increasing levels of a protein that helps the brain use cholesterol may slow the development of Alzheimer's disease changes in the brain, according to researchers studying a mouse model of the disease at Washington University School of Medicine in St. Louis.

18 Jan 2008

Mouse model shows potential efficacy of HIV prevention strategy

A new kind of laboratory mouse can be used to test the efficacy of much-needed methods to prevent transmission of HIV, the virus that causes AIDS, according to research by J. Victor Garcia and colleagues at the University of Texas Southwestern Medical Center in Dallas.

15 Jan 2008

Anti-retrovirals given daily before and after exposure to HIV prevent vaginal transmission AIDS virus

Prescription drugs now used to treat human immunodeficiency virus infection in adults may prevent the vaginal transmission of HIV, researchers at UT Southwestern Medical Center have found.

15 Jan 2008

Life savers in the gut

Researchers from the European Molecular Biology Laboratory (EMBL) have discovered that proteins that regulate the body's iron household play a vital role in making sure enough nutrients and water are absorbed in the intestine.

10 Jan 2008

Researchers trigger insulin production in diabetic mice

If the human body were a stage, then proteins would rank among the lead actors in the play we call "Life."

9 Jan 2008

Freeze-dried tendon grafts loaded with gene therapy may provide repair injured tendons

According to study data published today in the journal Molecular Therapy, a new graft technique may provide the first effective framework around which flexor tendon tissue can reorganize as it heals.

9 Jan 2008

Scientists restore walking after spinal cord injury

Spinal cord damage blocks the routes that the brain uses to send messages to the nerve cells that control walking.

7 Jan 2008

Novel mechanism for long-term learning identified

Practice makes perfect - or at least that's what we're told as we struggle through endless rounds of multiplication tables, goal kicks and piano scales - and it seems, based on the personal experience of many, to be true.

4 Jan 2008

Down syndrome points to a new way of repressing cancer growth

Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model. Publishing in the Jan. 3 issue of Nature, the research team describes how trisomy 21, or Down syndrome in humans, can repress tumor growth.

4 Jan 2008

Il-22 gene delivers the goods and decreases intestinal inflammation

There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC).

3 Jan 2008

Epilepsy and brain pathology linked together by the protein ADK

The brain of individuals who suffer from epilepsy is characterized by astrogliosis, a brain pathology evidenced by a complex series of changes in the morphology and function of brain cells known as astrocytes.

3 Jan 2008

Rituximab may be promising treatment for diabetes

An antibody used to treat certain cancers and rheumatoid arthritis appears to greatly delay type 1 diabetes in mice, Yale School of Medicine researchers report in the Journal of Clinical Investigation.

20 Dec 2007

Surprising findings related to myotonic muscular dystrophy and heart protein

New research from the University of Virginia Health System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does several surprising things.

18 Dec 2007

New findings on myotonic muscular dystrophy

New research from the University of Virginia Health System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does several surprising things. DM1 is the most common form of muscular dystrophy in adults and affects approximately 40,000 adults and children in the U.S.

18 Dec 2007

Intracellular bacterial communities in cystitis; rifapentine cures TB in mouse model; and more

A study published this week in the open access journal PLoS Medicine presents convincing evidence that intracellular bacterial communities (IBCs) commonly exist in women with bladder infections and may contribute to the recurrence of these infections.

18 Dec 2007

Reprogrammed human adult stem cells rescue diseased muscle in mice

Scientists report that adult stem cells isolated from humans with muscular dystrophy can be genetically corrected and used to induce functional improvement when transplanted into a mouse model of the disease.

13 Dec 2007

Discovery of key mechanism underlying idiopathic pulmonary fibrosis

A study led by Massachusetts General Hospital (MGH) researchers may have found a key mechanism underlying idiopathic pulmonary fibrosis (IPF), a usually fatal lung disease for which transplantation is the only successful treatment.

13 Dec 2007