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Funding boost in fight against leukaemia

University of Manchester researchers have been awarded £1.6 million to study a group of genes identified as playing a key role in leukaemia.

From The University of Manchester 3 Jul 2008

Microchip-based device determines the genetic signature of lung tumors

Massachusetts General Hospital (MGH) investigators have shown that an MGH-developed, microchip-based device that detects and analyzes tumor cells in the bloodstream can be used to determine the genetic signature of lung tumors, allowing identification of those appropriate for targeted treatment and monitoring genetic changes that occur during therapy. A pilot study of the device called the CTC-chip will appear in the July 24 New England Journal of Medicine and is receiving early online release.

3 Jul 2008

New clues to the biological basis of migraines

Fifteen percent to 20 percent of people worldwide suffer from migraines - excruciating headaches often presaged by dramatic sensations, or "auras." By studying a rare, inherited form of migraine, researchers at Vanderbilt University Medical Center have found clues to the biological basis of the painful, debilitating disorder.

1 Jul 2008

Children's Brain Tumor Foundation's tissue bank consortium may solve dire problem in pediatric cancer research

In a major effort to speed treatment and cures for pediatric brain tumors and cancer, the Children's Brain Tumor Foundation (CBTF) today launched the initial phase of a tissue bank consortium designed to jump-start meaningful analyses that could lead to treatment and cures for these types of cancer, where survival rates are unacceptably low and neurocognitive and other damage is posed by today's treatment options.

1 Jul 2008

Electrostatic-based RNA assays technique could revolutionize medical diagnostics

The dream of personalized medicine - in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profile - may be on the verge of being expanded beyond the wealthiest of nations with state-of-the-art clinics.

30 Jun 2008

Neural stem cell development may be linked to Autism

In a breakthrough scientific study published today in the Proceedings of the National Academy of Sciences, scientists at the Burnham Institute for Medical Research have shown that neural stem cell development may be linked to Autism.

30 Jun 2008

Zinc finger technology brings personalized HIV therapy a step closer

Researchers at the University of Pennsylvania School of Medicine and collaborators are using minute, naturally occurring proteins called zinc fingers to engineer T cells to one day treat AIDS in humans.

30 Jun 2008

Novel approach for treating mitochondrial disorders wins Kaye prize

A novel concept for the treatment of mitochondrial disorders using directed enzyme replacement therapy (DERT) has won for a Hebrew University of Jerusalem doctoral candidate one of this year's Kaye Innovation Awards. The awards were presented at this year's 71st meeting of the Hebrew University Board of Governors.

30 Jun 2008

Growth-stimulating molecule called p110beta a promising cancer drug target in prostate tumors

Scientists at Dana-Farber Cancer Institute report they have blocked the development of prostate tumors in cancer-prone mice by knocking out a molecular unit they describe as a "powerhouse" that drives runaway cell growth.

27 Jun 2008

Aventix Pharma takes over key patents for innovative screening tool for treatments for cystic fibrosis

The rights to key patents for an innovative screening tool for treatments for cystic fibrosis were transferred today to Swiss biotech company Axentis Pharma AG.

26 Jun 2008

Discovery of second genetic risk factor for developing late-onset Alzheimer's disease

Researchers have discovered the second, strong genetic risk factor for developing late-onset Alzheimer's disease, according to a new report in the June 27th issue of the journal Cell, a Cell Press publication.

25 Jun 2008

Study uncovers a mechanism that explains calcium abnormalities in Alzheimer's brain

A new study uncovers a mechanism that directly links mutations that cause early onset Alzheimer's disease (AD) with aberrant calcium signaling. The research, published by Cell Press in the June 26th issue of the journal Neuron, provides exciting molecular insights into the pathology of AD and may lead to new treatment strategies.

25 Jun 2008

tRNA import occurs in humans - could lead to targeted therapies

Scientists have determined that human cells are able to shift important gene products into their own mitochondria, considered the power plants of cells. The finding could eventually lead to therapies for dozens of diseases.

24 Jun 2008

Genetic mutation and cat exposure at birth may increase a child's risk of developing eczema

A gene mutation and cat exposure at birth may increase a child's risk of developing eczema during their first year according to a study published in PLoS Medicine. Researchers led by Professor Hans Bisgaard (University Hospital Gentofte, Copenhagen, Denmark) studied the association between mutations in the filaggrin gene (FLG) and exposure to environmental factors with the development of eczema.

24 Jun 2008

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature Medicine publishes the findings in its online June 22 edition.

23 Jun 2008

Melanomas "run" in families - CDKN2A gene reveals why

When people know the results of genetic tests confirming they have inherited an increased risk of developing melanoma, they follow skin cancer screening recommendations more proactively-much like those who have already been diagnosed with the potentially deadly disease, according to results of a study completed at the University of Utah's Huntsman Cancer Institute. and published in the June issue of Cancer Epidemiology, Biomarkers & Prevention.

17 Jun 2008

Discovery of mechanisms that direct cholinergic synapse assembly between neurons in vivo

Rapid information processing in the nervous system requires synapses, specialized contact sites between nerve cells and their targets. One particular synapse type, cholinergic, uses the chemical transmitter acetylcholine to communicate between nerve cells. Cholinergic synapses are essential for normal learning and memory, arousal, attention, and all autonomic (involuntary) nervous system functions.

16 Jun 2008

Hong Kong battling with bird flu outbreak

An outbreak of the deadly H5N1 bird flu virus in poultry in Hong Kong food markets has led to the culling of live poultry across the city.

16 Jun 2008

Roche chlamydia test approved in Europe

Roche has announced that its new test for detection of Chlamydia trachomatis has received CE Mark certification, allowing it to be sold for clinical use in the European Union.

15 Jun 2008

Researchers identify biomarkers of early-stage pancreatic cancer in mice and man

A multicenter team of researchers has identified a panel of proteins linked to early development of pancreatic cancer in mice that applies also to early stages of the disease in humans - a breakthrough that brings scientists a significant step closer to developing a blood test to detect the disease early, when cure rates are highest.

10 Jun 2008

Mutation News and Research

Funding boost in fight against leukaemia

Microchip-based device determines the genetic signature of lung tumors

New clues to the biological basis of migraines

Children's Brain Tumor Foundation's tissue bank consortium may solve dire problem in pediatric cancer research

Electrostatic-based RNA assays technique could revolutionize medical diagnostics

Neural stem cell development may be linked to Autism

Zinc finger technology brings personalized HIV therapy a step closer

Novel approach for treating mitochondrial disorders wins Kaye prize

Growth-stimulating molecule called p110beta a promising cancer drug target in prostate tumors

Aventix Pharma takes over key patents for innovative screening tool for treatments for cystic fibrosis

Discovery of second genetic risk factor for developing late-onset Alzheimer's disease

Study uncovers a mechanism that explains calcium abnormalities in Alzheimer's brain

tRNA import occurs in humans - could lead to targeted therapies

Genetic mutation and cat exposure at birth may increase a child's risk of developing eczema

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

Melanomas "run" in families - CDKN2A gene reveals why

Discovery of mechanisms that direct cholinergic synapse assembly between neurons in vivo

Hong Kong battling with bird flu outbreak

Roche chlamydia test approved in Europe

Researchers identify biomarkers of early-stage pancreatic cancer in mice and man

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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