Mutation News and Research

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Caspase-12: MUHC researcher finds new defense mechanism against intestinal inflammation

The body's first line of defence against pathogenic bacteria that we ingest may not be the immune system but rather the cells that line the intestine.

13 Mar 2008

New genetic finding on Rett syndrome

The first comprehensive analysis of the clinical effects of genetic mutations involved in Rett syndrome will enable affected families to receive a more accurate indication of their child's prognosis.

12 Mar 2008

Novel brain cancer drug HhAntag for children may damage bones

A novel drug that fully eliminated brain tumors from mice in a dramatic 2004 study has shown a darker side - causing permanent bone damage in younger mice.

11 Mar 2008

Mouse model for human malignant mesothelioma

Scientists have established a mouse model for human malignant mesothelioma (MM) that will provide valuable insight into cancer development and progression along with new directions for design of therapeutic strategies.

11 Mar 2008

Pesticides and nerve agents explain health problems in Persian Gulf war veterans

A study by researchers at the University of California, San Diego School of Medicine shows there is increasing evidence that high rates of illness in Persian Gulf War Veterans can be explained, in part, by exposure to certain chemicals, including pesticides and nerve agents.

11 Mar 2008

Tackling antimicrobial resistance

Drug resistance is making many diseases increasingly difficult and sometimes impossible to treat, according to Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

11 Mar 2008

Advanced-stage ovarian cancer patients with BRCA live longer, may respond better to treatment

Two abstracts underscoring the importance of testing for BRCA1/2 mutations in women with ovarian cancer were presented at this week's Society of Gynecologic Oncologists 39th Annual Meeting on Women's Cancers, by researchers from The University of Texas M. D. Anderson Cancer Center.

11 Mar 2008

Japanese find way to make flu vaccine effective for multiple strains

Japanese scientists say they are well on the way to developing influenza vaccines which are effective for multiple strains of the disease, including strains of the bird flu virus.

11 Mar 2008

The brain's melanocortin system points to new treatments for obesity and anorexia

The discovery of the brain's so-called melanocortin system and its central role in controlling appetite has paved the way for entirely new possibilities for treating obesity and anorexia.

10 Mar 2008

Genetic research unveils common origins for distinct clinical diagnoses

Researchers at Johns Hopkins have discovered that two clinically different inherited syndromes are in fact variations of the same disorder.

10 Mar 2008

Another wild bird in Hong Kong tests positive for H5N1

Authorities in Hong Kong say a wild oriental magpie robin found dead ten days ago has tested positive for the deadly H5N1 strain of the bird flu virus.

9 Mar 2008

Research helps explain why some flu strains cause major pandemics and others lead to seasonal epidemics

The exchange of genetic material between two closely related strains of the influenza A virus may have caused the 1947 and 1951 human flu epidemics, according to biologists.

6 Mar 2008

Integrin beta3 protein yields clues to autism

Many children with autism have elevated blood levels of serotonin - a chemical with strong links to mood and anxiety.

6 Mar 2008

New malaria drug also treats toxoplasmosis

A new drug that will soon enter clinical trials for treatment of malaria also appears to be 10 times more effective than the key medicine in the current gold-standard treatment for toxoplasmosis, a disease caused by a related parasite that infects nearly one-third of all humans—more than two billion people worldwide.

6 Mar 2008

Alcohol may increase blood pressure to a much greater extent than previously thought

Previous observational studies have reported that heavy alcohol intake is a risk factor for hypertension but such studies may be confounded by factors such as diet, smoking, exercise levels and socio-economic position.

6 Mar 2008

Genetic mutations involved in IGF-I signaling pathway influence life span

Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found.

6 Mar 2008

New genetic marker of risk for breast cancer discovered

An international group of investigators led by scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) and the National Cancer Institute has identified a new genetic marker of risk for breast cancer.

4 Mar 2008

How variants of a specific gene, CAPON or NOS1AP, can disrupt normal heart rhythm

A research team from the Cedars-Sinai Heart Institute, Johns Hopkins University and China Medical University and Hospital in Taiwan have described for the first time the mechanisms by which variants of a specific gene, CAPON or NOS1AP, can disrupt normal heart rhythm.

4 Mar 2008

Guidelines for von Willebrand disease diagnosis and management

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health today issued the first clinical guidelines in the United States for the diagnosis and management of von Willebrand Disease (VWD), the most common inherited bleeding disorder.

4 Mar 2008

Discovery of key molecular mechanism associated with cystic fibrosis

Researchers from the University of North Carolina at Chapel Hill have identified a key molecular mechanism that may account for the development of cystic fibrosis.

4 Mar 2008