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Muscular German boy sheds new light on muscle development and genetics

By studying the genetic make up of a German boy born with unusually well developed muscles, an international research team has discovered the first evidence that the gene whose loss makes "mighty mice" also controls muscle growth in people.

24 Jun 2004

Microchip to track genetic signature of cancer and normal tissue

MicroRNAs (miRNAs), tiny pieces of genetic material that can serve as stop signs for gene expression and protein synthesis, are thought to be important in the development of cancer.

23 Jun 2004

Cognitive decline can occur before chemotherapy treatment

In a series of studies in breast cancer patients, researchers at The University of Texas M. D. Anderson Cancer Center have confirmed the presence of “chemobrain” after chemotherapy treatment – but they also discovered that a significant portion of patients have cognitive declines even before chemotherapy.

21 Jun 2004

Bionomics and Nanogen reach milestone on the development of genetic tests for serious forms of childhood epilepsy

Bionomics Limited has announced that it had achieved a further milestone in its collaboration with Nanogen on the development of genetic tests for serious forms of childhood epilepsy

21 Jun 2004

New findings may help better understand how harmless viruses can cause severe disease among patients with weakened immune systems

When a major branch of the mouse immune system is disabled, a normally harmless virus can rapidly mutate into a lethal one, according to researchers at Washington University School of Medicine in St. Louis.

17 Jun 2004

More precise and less invasive procedure for prostate cancer detection

Work by a University of Queensland researcher will make the trip to the doctor for a prostate cancer check a lot more appealing for men.

17 Jun 2004

Simple genetic code might work to wire up the body from head to foot

The study found that when a development gene named Hoxb1 worked in a mouse’s brain but not in the developing facial tissues, nerves extended outward from the brain but failed to reach the facial muscles, leaving the mouse unable to blink its eyes, flatten its ears or make other facial movements.

15 Jun 2004

Body fat not always bad

With the threat of an obesity crisis looming, a study led by UCL researchers reveals today that fat tissue isn’t always the enemy. Reporting in the journal Science they show that a molecular signalling pathway in fat tissue is an important mediator in extending lifespan.

11 Jun 2004

Pathogens have the ability to cause late-onset sporadic Alzheimer's disease

The possibility of an infectious etiology of chronic diseases, including Alzheimer’s disease, has long been debated and is difficult to prove.

11 Jun 2004

Genetic link between hormones and migraine

Director of the Genomics Research Centre Professor Lyn Griffiths and her team of researchers at Griffith University have identified a genetic link between hormones and migraine.

9 Jun 2004

SU11248 proves effective in the treatment of gastrointestinal stromal tumors

A drug originally developed to block the formation of blood vessels in tumors has been shown to overcome resistance to treatment with Gleevec in patients with gastrointestinal stromal tumors (GIST).

9 Jun 2004

Gene mutation found in some women may decrease effectiveness of tamoxifen breast cancer drug

Researchers from the Johns Hopkins Kimmel Cancer Center, Indiana University and the University of Michigan have found that some women have a gene mutation that may decrease the effectiveness of tamoxifen, a commonly used breast cancer drug.

7 Jun 2004

Research may help treat muscular dystrophies and other muscle diseases caused by glycosylation defects

Expressing high levels of a sugar-adding protein known as LARGE in mice that lack the protein can prevent muscular dystrophy in these animals, according to studies by researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

7 Jun 2004

Crucial discovery may help better diagnose and treat children with Hirschsprung disease

Researchers at Fox Chase Cancer Center have made a crucial discovery that may help physicians better diagnose and treat children with Hirschsprung disease, a debilitating and sometimes life-threatening ailment that causes bowel obstruction and involves an array of genetic changes.

5 Jun 2004

High school student makes significant contribution to breast cancer research

A high school student from Albany, New York, has made a significant contribution toward understanding how mutations to a gene called BRCA-1 contributes to hereditary breast cancer.

5 Jun 2004

Computational design used to engineer and construct a protein that could sense the nerve agent soman

Duke University Medical Center biochemists have used computational design to engineer and construct a protein that could sense the nerve agent soman. They said their achievement constitutes a proof-of principle that such engineered proteins can be made to detect nerve agents such as sarin and other toxic substances.

5 Jun 2004