Nanoparticle News and Research

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In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: in terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers.

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Though researchers have made substantial progress in developing drug-ferrying nanoparticles that successfully target tumor cells in living animals, including humans, investigators have only now started the detailed work needed to identify formulation parameters that would optimize drug delivery to malignant cells.

6 Nov 2006

Detecting rare microRNAs with gold nanoparticles

Over the past three years, numerous studies have shown that short pieces of single-stranded RNA, known as microRNAs, play a central role in the development of at least some cancers.

30 Oct 2006

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Silica, the mineral of which sand is made, is generally inert in the body and can be modified easily using a variety of well-established chemical reactions.

30 Oct 2006

Self-assembling nanoparticle releases drug into cell cytoplasm

A growing body of research leaves no doubt that nanoparticles can transport drugs into cancer cells, but what is less clear is that the drug payload can exit the tiny endosomes that pull nanoparticles into cells.

30 Oct 2006

Multivalent effects of RGD peptides obtained by nanoparticle display

While a growing body of literature has shown that nanoparticle targeting can improve drug delivery and tumor imaging, there have been few systematic studies examining the net positive effect of nanoparticle targeting.

23 Oct 2006

Squalenoyl nanomedicines as potential therapeutics

Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

23 Oct 2006

New technique detects signature of metastasizing melanoma with as few as 10 cancer cells present in blood sample

Researchers at the University of Missouri-Columbia can now detect the spread of skin cancer cells through the blood by literally listening to their sound.

16 Oct 2006

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors.

16 Oct 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

One of the unusual properties of tumor cells is that their cell membranes are more fluid and less rigid than those of normal cells.

16 Oct 2006

Calls for FDA to pay more attention to products made with nanotechnology

At a meeting called by the U.S. Food and Drug Administration (FDA), consumer and environmental groups have called for the FDA to pay more attention to products made by using nanotechnology.

11 Oct 2006

Photochemistry creates drug-trapping nanoparticles

Many of the most potent anticancer agents are poorly soluble in water, presenting a challenge for medicinal chemists who must develop methods of delivering these drugs in the watery environment of the human body.

9 Oct 2006

Nanoparticle encapsulation improves bioavailability of leukemia drug

Busulfan, which belongs to a family of drugs known as alkylating agents, is used to treat hematological malignancies, including chronic myelogenous leukemia.

9 Oct 2006

Key parameters for encapsulating drugs in nanoparticles

One of the early, successful uses of nanoparticles has been to develop delivery vehicles capable of ferrying large amounts of water-insoluble drugs to tumors.

2 Oct 2006

Temperature-sensitive nanoparticle boosts drug antitumor activity

Using temperature-sensitive, lipid- and polymer-based nanoparticles with a polymer coating, researchers in Korea have created an anticancer drug delivery vehicle that may provide a significant boost to the therapeutic efficacy of anticancer agents, particularly when used in conjunction with hyperthermia.

2 Oct 2006

Smart nanoscale bioreactors for drug delivery

In a powerful demonstration of how to build a multifunctional, smart nanoscale drug delivery system, researchers at the University of Basel have created a drug-loaded nanocontainer that targets specific cells and releases its payload when receiving a specific physiological signal.

2 Oct 2006

Nanoparticle News and Research

Further Reading

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Detecting rare microRNAs with gold nanoparticles

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Self-assembling nanoparticle releases drug into cell cytoplasm

Multivalent effects of RGD peptides obtained by nanoparticle display

Squalenoyl nanomedicines as potential therapeutics

New technique detects signature of metastasizing melanoma with as few as 10 cancer cells present in blood sample

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

Calls for FDA to pay more attention to products made with nanotechnology

Photochemistry creates drug-trapping nanoparticles

Nanoparticle encapsulation improves bioavailability of leukemia drug

Key parameters for encapsulating drugs in nanoparticles

Temperature-sensitive nanoparticle boosts drug antitumor activity

Smart nanoscale bioreactors for drug delivery

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer

Detecting cancer with silica nanoparticles

Could quantum dots hold the cure to cancer?

MRI tracks survival of pancreatic islets after transplantation

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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