Nanoparticle News and Research

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In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: in terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers.

Nanoparticles from crab shells show promise for drug delivery

Nanoparticles made of chitosan, a naturally occuring polymer isolated from crab and shrimp shells, have shown promise as carriers of anticancer drugs, antitumor genes, and other novel therapeutic agents.

22 Jan 2007

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Iron oxide nanoparticles have shown promise as agents for detecting tumors using magnetic resonance imaging (MRI), but such efforts have been limited by the relatively weak magnetic signal generated by these nanoparticles.

22 Jan 2007

Nanoparticles yield delivery tools for therapeutic nucleic acids

Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.

16 Jan 2007

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles

Researchers at Montana State University have used an engineered form of ferritin, a cage-like iron storage protein, to both synthesize and deliver iron oxide nanoparticles to tumors.

16 Jan 2007

Biomimetic amplification of nanoparticle homing to tumors

A collaborative, multidisciplinary team of researchers has created nanoparticles that act much like a developing clot to target tumors.

16 Jan 2007

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Glioblastoma multiforme is among the most aggressive and difficult cancers to treat. Now, researchers at Penn State University have shown that a lipid-based nanoparticle, designed to bind to a specific receptor found on malignant brain cells but not healthy ones, improves the potency of a common anticancer drug and slows significantly the growth of glioblastoma in mice.

8 Jan 2007

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

By combining a quantum dot with a novel carrier of the magnetic resonance imaging (MRI) agent gadolinium, a team of investigators at the University of Maastricht, in The Netherlands, has developed a nanoparticle that can spot apoptosis, or programmed cell death, using both MRI and fluorescence imaging.

8 Jan 2007

NanoMed Pharmaceuticals issued new U.S. nanoparticle patent

NanoMed Pharmaceuticals has announced that founders Russell J. Mumper, Ph.D. and Michael Jay, Ph.D. have been issued U.S. Patent 7,153,525 entitled "Microemulsions As Precursors To Solid Nanoparticles."

3 Jan 2007

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

In an attempt to determine what factors make one nanoparticle better than another at targeting tumors, a team of investigators in Korea have conducted a systematic tumor-targeting study of a variety of self-assembling nanoparticles.

18 Dec 2006

Better magnetic nanoparticles

Using a polymer coating designed to resemble the outer surface of a cell membrane, a team of investigators led by Steve Armes, Ph.D., of the University of Sheffield in the United Kingdom, has created a highly stable, biocompatible magnetic nanoparticle expected to improve the sensitivity of magnetic resonance imaging (MRI).

18 Dec 2006

New X-ray microscope shows nanomaterials in 3D

Using a new x-ray microscope that can look at nanomaterials in three dimensions, an international research team has produced the first detailed atomic structure of a core-shell nanoparticle.

18 Dec 2006

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Though gene therapies hold great promise for treating cancer, it has proven difficult to deliver therapeutic genes efficiently into cancer cells.

18 Dec 2006

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

In the first experiments of their kind, researchers have determined that carbon nanotubes injected directly into the bloodstream of research lab animals cause no immediate adverse health effects and circulate for more than one hour before they are removed by the liver.

18 Dec 2006

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

Nanoscale, inorganic fluorescent imaging agents such as quantum dots have become an important tool for researchers studying key biomolecules involved in cancer.

18 Dec 2006

FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents

Alloys of iron and cobalt generate powerful magnetic signals that could be useful in nanoparticles designed to detect tumors using magnetic resonance imaging (MRI).

18 Dec 2006

Vascular targeted nanoparticles for imaging and treatment of brain tumors

Combining two promising approaches to diagnosing and treating cancer, a multidisciplinary research team at the University of Michigan has created a targeted multifunctional polymer nanoparticle that successfully images and kills brain tumors in laboratory animals.

4 Dec 2006

Nanoparticle News and Research

Further Reading

Nanoparticles from crab shells show promise for drug delivery

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Nanoparticles yield delivery tools for therapeutic nucleic acids

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles

Biomimetic amplification of nanoparticle homing to tumors

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

NanoMed Pharmaceuticals issued new U.S. nanoparticle patent

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

Better magnetic nanoparticles

New X-ray microscope shows nanomaterials in 3D

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents

Vascular targeted nanoparticles for imaging and treatment of brain tumors

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

Cytogen issued new patent covering oral drug delivery agents

Nanotechnology continues to advance anticancer gene therapy

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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