Necroptosis News and Research

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Scientists discover cell protein crucial in preventing viral replication

A research team has discovered a protein without which cells infected by viruses cannot trigger an immune response, leading to 100% mortality with even non-disease-producing strains. The discovery of the new Z-DNA binding protein, or ZBP1, was reported in the journal Frontiers in Microbiology. It could help develop new treatment methods for viruses that target the nervous system such as the Zika or West Nile Encephalitis virus.

6 Nov 2019

Researchers identify genetic mutation that causes idiopathic pulmonary fibrosis

Researchers in Japan have identified a genetic mutation that causes a severe lung disease called idiopathic pulmonary fibrosis by killing the cells lining the lung's airways.

10 Oct 2019

Study sheds light on complex caspase-1-induced cell death mechanisms

Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program.

5 Jul 2019

Researchers propose a new look at the role of ferroptosis in cancer development

Professor of Ghent University and Lead Researcher at the Institute of Biology and Biomedicine of the Lobachevsky University Dmitri Krysko together with scientists from Germany, Professor Marcus Conrad and Professor Jose Pedro Friedmann Angeli recently published an article in the journal Nature Reviews Cancer, one of the highest-rated journals that occupies the 2nd line in the oncology section among 223 journals in this category and has an impact factor of 42.78 according to WoS data.

7 Jun 2019

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo.

4 Jun 2019

Researchers identify new molecular mechanism causing rheumatoid arthritis

A collaborative study by research groups from the University of Cologne, VIB, Ghent University, the Βiomedical Sciences Research Center 'Alexander Fleming' in Athens and the University of Tokyo identified a new molecular mechanism causing rheumatoid arthritis.

14 May 2019

Researchers discover how an executioner mechanism is triggered to kill damaged cells

Researchers led by St. Jude Children's Research Hospital structural biologists have discovered how the cell switches on an executioner mechanism called necroptosis that induces damaged or infected cells to commit suicide to protect the body.

27 Apr 2019

Key proteins can block Listeria without triggering the death of host cells

New North Carolina State University research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells.

19 Apr 2019

Down syndrome may hold important clues to onset of Alzheimer's disease

At first glance, Down syndrome and Alzheimer's disease, two severe brain abnormalities, may seem to have little in common. Down syndrome is a hereditary disease, the source of which has long been recognized--a triplication of chromosome 21.

17 Oct 2018

Cellular environment affects type of tumor development

Liver cancer is the second leading cause of cancer death worldwide. Two different forms of primary liver cancer cover the majority of cases: About 10 to 20 percent of those affected develop a bile duct carcinoma within the liver (intrahepatic cholangiocellular carcinoma; ICC), the far higher proportion of liver cancers are hepatocellular carcinomas.

12 Sep 2018

New treatment destroys part of tumor and attacks persistent surviving cancer cells

Scientists at the VIB-UGent Center for Medical Biotechnology have taken important steps forward in the development of a cancer-targeting immunotherapy.

24 Aug 2018

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Most neurons in the human brain live out their lives, enduring the processes of aging before eventually dying. Some, however, choose a more violent route: suicide.

24 Aug 2018

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

Alcohol increases the mortality of young but not old mice infected with the tuberculosis-causing bacterium Mycobacterium tuberculosis, and this effect is mediated by the production of a protein called interferon-alpha.

3 Aug 2018

Study reveals how M. tuberculosis escapes death in macrophages

The bacteria that cause the devastating disease tuberculosis have the ability to escape destruction and grow after they are engulfed by lung macrophages, the immune cells that are supposed to destroy pathogens.

10 Jul 2018

Scientists discover the molecular trigger of necroptosis

Researchers have uncovered a trigger for an immune-related cell death pathway called necroptosis. The discovery could be used to develop new treatments for cancer and immune disorders.

21 Jun 2018

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases.

18 Jul 2017

Necroptosis News and Research

Scientists discover cell protein crucial in preventing viral replication

Researchers identify genetic mutation that causes idiopathic pulmonary fibrosis

Study sheds light on complex caspase-1-induced cell death mechanisms

Researchers propose a new look at the role of ferroptosis in cancer development

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

Researchers identify new molecular mechanism causing rheumatoid arthritis

Researchers discover how an executioner mechanism is triggered to kill damaged cells

Key proteins can block Listeria without triggering the death of host cells

Down syndrome may hold important clues to onset of Alzheimer's disease

Cellular environment affects type of tumor development

New treatment destroys part of tumor and attacks persistent surviving cancer cells

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

Study reveals how M. tuberculosis escapes death in macrophages

Scientists discover the molecular trigger of necroptosis

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Immunologists discover how rescue proteins delay ‘executioner’ machinery that kills damaged cells

Scientists discover potent trigger of inflammatory disease

Researchers unravel puzzle of necroptosis

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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