Necroptosis News and Research

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Researchers identify key mechanisms to address future treatments for hereditary blindness

There are still many enigmas about the mechanism of action of the CERKL gene, which causes retinitis pigmentosa and other hereditary vision diseases.

18 Sep 2023

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

Dendritic cells found to kill CD47-deficient T cells

Researchers at Kobe University discovered an entirely new and unexpected mechanism by which the immune system can get rid of cells lacking molecules that identify them as part of the self in mice.

8 Aug 2023

The role of airway epithelium: insights into asthma and COPD pathogenesis

Study discussed how injury and abnormal repair of the airway epithelium drive chronic obstructive pulmonary disease (COPD) and asthma.

17 Jul 2023

Pyroptosis: A potential therapeutic target for lung cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

28 Jun 2023

Investigating the alveolar type II reparative response in COVID-19 pneumonia

Researchers investigated the alveolar type II reparative response in COVID-19 pneumonia.

9 Jun 2023

Novel optical imaging approach provides four-dimensional view of cell secretions

Cell secretions like proteins, antibodies, and neurotransmitters play an essential role in immune response, metabolism, and communication between cells.

11 Apr 2023

Pneumolysin toxin holds promise for developing therapies against Streptococcus pneumoniae

In a recent study published in the journal PLoS ONE, researchers in Spain performed a systematic review of pneumolysin (PLY) toxin as a molecular target to develop novel therapeutics against Streptococcus pneumoniae.

27 Mar 2023

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

Researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.

20 Feb 2023

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points.

9 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

New insights into the dynamic inner world of the human immune system

As researchers glean new insights into the dynamic inner world of the human immune system, it has become increasingly clear that mitochondria are critical regulators of how our bodies respond to disease.

3 Nov 2022

Novel member of a class of anti-diabetes drugs could help treat muscle wasting disease

Inflammatory myopathies can be challenging to treat, but a new study reports encouraging findings for patients with these debilitating conditions. Researchers from Japan have found that a novel member of a class of anti-diabetes drugs could be the key to treating patients with muscle wasting disease.

18 Aug 2022

Scientists unlock a new approach to kill hard-to-treat cancers

In a paper appearing in Nature today, an international group of scientists have unlocked a new way to kill hard to treat cancers. These tumors resist current immunotherapies, including those using Nobel Prize winning check-point blocking antibodies.

26 May 2022

Study reveals how ZBP1 could lead to a cytokine storm during COVID-19

Scientists from St. Jude Children's Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell death pathway, PANoptosis, are major contributors to the negative effects of interferon treatment and high interferon levels in some COVID-19 patients.

20 May 2022

Targeting necroptosis using a necroptosis inhibitor lessens myositis-induced muscle weakness

A new study has suggested that treatment to target necroptosis in muscle fibers using a necroptosis inhibitor lessens myositis-induced muscle weakness as well as muscle cell death and inflammation in the muscles. This has been shown to be a promising strategy for treating polymyositis.

2 Mar 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Relationship between SARS-CoV-2 neurotropism and Alzheimer's disease

In a new study, researchers evaluated the neurotropism of SARS-CoV-2 and its impact on COVID-19 patients with and without neurological disorders like Alzheimer's disease.

3 Feb 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022