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Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

The potential variations in sperm quality of infertile patients during the COVID-19 pandemic

A recent study investigated how SARS-CoV-2 infection affected the semen quality of infertile men in Tunisia.

10 May 2023

Can intermittent fasting tackle obesity-related inflammation?

Research reviews the effects of two forms of intermittent fasting, time-restricted eating (TRE) and alternate-day fasting (ADF), on body weight and key circulating inflammatory markers (CRP, TNF-alpha, and IL-6) in adults with obesity. The results suggest that intermittent fasting has little or no effect on key inflammatory markers, but more research is needed to confirm these findings.

8 May 2023

Study suggests SARS-CoV-2 vaccination in pregnancy induces diverging maternal and infant cord antibody functions

Researchers explored the differences in infant and maternal cord antibody functions between SARS-CoV-2 infection and vaccination during pregnancy.

4 May 2023

Can smoking cigarettes alter your bone structure?

Researchers aimed to understand how exposure to cigarette smoke causes alterations in bone structure.

2 May 2023

Study identifies immune signature to predict severe COVID-19 in cardiovascular patients

Research investigates whether the severity of SARS-CoV-2 infection can be predicted by analyzing the immunophenotype in the blood of cardiovascular disease (CVD) patients.

1 May 2023

Study sheds light on immune factors responsible for contrasting SARS-CoV-2 outcomes in humans and white-tailed deer

Researchers explored the response of respiratory epithelial cells in deers to SARS-CoV-2.

27 Apr 2023

Research identifies Th1 memory CD4+ T cells as key to protect against emerging poxvirus skin infections

Researchers demonstrate that T helper 1 effector memory cluster of differentiation 4 T cells provide immunity against poxviruses

27 Apr 2023

Neutrophils found to play a key role in fibromyalgia pain

Targeting neutrophil activity and interactions with sensory neurons may be a potential approach for treating fibromyalgia pain.

25 Apr 2023

Is there a correlation between acute and chronic red wine intake and health?

Researchers examined the correlations between acute and chronic red wine (RW) intake and health.

18 Apr 2023

Edible mushrooms: the role of antioxidant compounds as potential candidates for neurodegenerative disease prevention and treatment

Researchers evaluated whether edible mushrooms aid in preventing neurodegenerative diseases.

18 Apr 2023

How does e-cigarette vapor alter the gut microbiome, body weight, and systemic inflammation levels?

Researchers examine the effects of electronic cigarette (e-cigarette) vapor on gut microbiome, body weight, and systemic inflammation levels.

11 Apr 2023

Antioxidant-rich phenolic compounds: A key to disease prevention, gut health, and brain homeostasis

Researchers report on the benefits of consuming dietary phenols and their relationship with the intestinal microbiome.

10 Apr 2023

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Study reviews the diagnosis and treatment of acute myocarditis

Scientists have recently reviewed and summarized the evidence regarding diagnosing and treating acute myocarditis.

6 Apr 2023

Can metabolic phenotyping of pregnant women, beyond pre-pregnancy obesity or gestational diabetes status, improve the assessment of adiposity risk in offspring?

Researchers assessed whether metabolic phenotyping during pregnancy increases the risk of adiposity risk in the offspring.

6 Apr 2023

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Researchers analyzed data on the association between intestinal microbiome dysbiosis and rheumatoid arthritis.

6 Apr 2023

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Researchers assessed the extent of SARS-CoV-2 Omicron VOC BA.5 sub-VOC infection-associated brain infection and death.

5 Apr 2023

Scientists unearth some of the biological mechanisms behind ferroptosis

A team of researchers at Tohoku University has unearthed some of the biological mechanisms of ferroptosis, a recently discovered type of regulated cell death that is triggered by iron and the accumulation of lipid peroxidation - lipids that have undergone oxidative degeneration.

5 Apr 2023

Necrosis News and Research

Genetic insights unveil promising therapeutic targets for critical COVID-19

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

The potential variations in sperm quality of infertile patients during the COVID-19 pandemic

Can intermittent fasting tackle obesity-related inflammation?

Study suggests SARS-CoV-2 vaccination in pregnancy induces diverging maternal and infant cord antibody functions

Can smoking cigarettes alter your bone structure?

Study identifies immune signature to predict severe COVID-19 in cardiovascular patients

Study sheds light on immune factors responsible for contrasting SARS-CoV-2 outcomes in humans and white-tailed deer

Research identifies Th1 memory CD4+ T cells as key to protect against emerging poxvirus skin infections

Neutrophils found to play a key role in fibromyalgia pain

Is there a correlation between acute and chronic red wine intake and health?

Edible mushrooms: the role of antioxidant compounds as potential candidates for neurodegenerative disease prevention and treatment

How does e-cigarette vapor alter the gut microbiome, body weight, and systemic inflammation levels?

Antioxidant-rich phenolic compounds: A key to disease prevention, gut health, and brain homeostasis

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

Study reviews the diagnosis and treatment of acute myocarditis

Can metabolic phenotyping of pregnant women, beyond pre-pregnancy obesity or gestational diabetes status, improve the assessment of adiposity risk in offspring?

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Scientists unearth some of the biological mechanisms behind ferroptosis

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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