Necrosis News and Research

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Male circumcision a 'staggeringly under-utilized tool'

"PrePex, the new nonsurgical circumcision tool experts believe could revolutionize the prevention of HIV and AIDS in sub-Saharan Africa, is easier to assemble than a toy you might find in a Happy Meal," freelance journalist Patrick Adams writes in the New York Times' "Opinionator" blog.

22 Mar 2013

New study may help develop targeted therapies for controlling tissue destruction

Stroke, heart attacks and numerous other common disorders result in a massive destruction of cells and tissues called necrosis. It's a violent event: As each cell dies, its membrane ruptures, releasing substances that trigger inflammation, which in turn can cause more cellular necrosis.

19 Mar 2013

Cytomegalovirus employs a novel trick to hide from immune detection

A virus that most people have probably never heard of, yet most of us carry, is the number 1 infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb.

17 Mar 2013

Research finding aids efforts toward cytomegalovirus vaccine

A virus most people probably have never heard of, but that the majority of us carry, is the No. 1 infectious cause of congenital birth defects in the U.S. today. Because of cytomegalovirus (CMV) infection during in utero development, 1 in 750 children are born with or develop permanent disabilities such as hearing loss or brain damage.

14 Mar 2013

Medication use and doctor visits drive up jaw necrosis-related costs

Long-term medication use and follow-up visits are the main drivers affecting costs associated with cancer-related bisphosphonate-associated osteonecrosis of the jaw, report researchers in Oral Diseases.

8 Mar 2013

Inflammatory marker for schizophrenia treatment resistance, severity

Levels of the inflammatory marker soluble tumor necrosis factor receptor 1 may be associated with severity of symptoms and treatment resistance in schizophrenia, say Brazilian scientists.

8 Mar 2013

RA patients who initiate anti-TNF therapies do not have higher risk of shingles: Study

Although patients with rheumatoid arthritis have a disproportionately higher incidence of herpes zoster (shingles), an analysis that included nearly 60,000 patients with RA and other inflammatory diseases found that those who initiated anti-tumor necrosis factor therapies were not at higher risk of herpes zoster compared with patients who initiated nonbiologic treatment regimens, according to a study appearing in the March 6 issue of JAMA.

7 Mar 2013

Eye-rubbing may provoke, aggravate keratoconus

Rubbing the eyes leads to an increase in protease activity and levels of protease and inflammatory mediators, a clinical study shows.

1 Mar 2013

Gene mutation findings classify renal cell carcinoma

Researchers have identified mutation-defined subtypes of clear cell renal cell carcinoma that have distinct clinical outcomes.

20 Feb 2013

Interleukin-10 levels predict otitis media culprit

Research shows that high serum levels of interleukin-10 indicate that the likely cause of acute otitis media is infection with Streptococcus pneumoniae, as opposed to Haemophilus influenzae or Moraxella catarrhalis.

18 Feb 2013

Combination of Methotrexat and Tofacitinib shows promise against rheumatoid arthritis

Together with colleagues from the international rheumatic diseases research community, scientists of the Charité - Universitätsmedizin Berlin have presented a new therapy approach for the treatment of rheumatoid arthritis (RA), a chronic form of joint inflammation.

14 Feb 2013

Biomarkers could be antidote to overdose overtreatment

Researchers have identified several biomarkers that can accurately predict acute liver injury after acetaminophen overdose.

11 Feb 2013

Etanercept no better than prednisone for COPD exacerbations

Results from a randomized, double-blind, controlled trial suggest that the tumor necrosis factor α antagonist etanercept is no more effective than standard therapy with prednisone for the treatment of acute exacerbations in patients with chronic obstructive pulmonary disease.

8 Feb 2013

Tumor necrosis factor receptor 2 involved in renal decline in diabetes

Researchers have found that circulating levels of tumor necrosis factor receptor 2 are independently associated with the development of chronic kidney disease in nonobese Japanese patients with Type 2 diabetes.

8 Feb 2013

Oral eosinophilic ulcers ‘a self-limiting, reactive condition’

A review of patients with oral eosinophilic ulcers suggests that the lesions should be considered a reactive, local condition rather than a CD30+ lymphoproliferative disorder.

8 Feb 2013

Regular exercise reduces development of painful diabetic neuropathy in animals

Regular exercise reduces the development of painful diabetic neuropathy in animals—apparently related to increased expression of a protective substance called "heat shock protein" 72 (Hsp72), reports an experimental study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

5 Feb 2013

Delayed hematuria common after prostate brachytherapy

A significant proportion of patients with prostate cancer who are treated with brachytherapy develop gross hematuria years later, report researchers.

4 Feb 2013

NSAIDs pose kidney risk in some children

A small but significant percentage of children develop acute kidney injury after taking nonsteroidal anti-inflammatory drugs such as ibuprofen, show study findings published in the Journal of Pediatrics.

29 Jan 2013

Five genes hold key to meningioma make up

Research published in Science shows that mutations in five genes characterize most meningiomas.

28 Jan 2013

IRHOM2-targeted drugs can effectively treat patients with rheumatoid arthritis

Researchers at Hospital for Special Surgery have identified a potential new target for drugs to treat patients with rheumatoid arthritis (RA), a protein known as IRHOM2. The finding could provide an effective and potentially less toxic alternative therapy to tumor necrosis factor-alpha blockers (TNF-blockers), the mainstay of treatment for rheumatoid arthritis, and could help patients who do not respond to this treatment. Efforts to develop drugs that hone in on this new target are underway.

28 Jan 2013