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Discovery of TRPC5 gene's role in obesity and postnatal depression offers hope for new treatments

Scientists have identified a gene which, when missing or impaired, can cause obesity, behavioral problems and, in mothers, postnatal depression. The discovery, reported today in Cell, may have wider implications for the treatment of postnatal depression, with a study in mice suggesting that oxytocin may alleviate symptoms.

8 Jul 2024

Neuromuscular training reduces chemotherapy-induced neuropathy and improves patient outcomes

Researchers found that neuromuscular training significantly reduces the incidence and severity of chemotherapy-induced peripheral neuropathy, improving patient quality of life and treatment outcomes.

7 Jul 2024

Innovative research sheds light on migraine mechanisms and potential therapies

New research describes for the first time how a spreading wave of disruption and the flow of fluid in the brain triggers headaches, detailing the connection between the neurological symptoms associated with aura and the migraine that follows.

4 Jul 2024

New signaling pathway identified in aural migraine headaches

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to a new mouse study.

4 Jul 2024

New insights into brain energy metabolism may lead to neurodegenerative disease therapies

A key mechanism which detects when the brain needs an additional energy boost to support its activity has been identified in a study in mice and cells led by UCL scientists.

3 Jul 2024

Gene discovery points to oxytocin for depression

While investigating two boys from different families with severe obesity, anxiety, autism, and behavioural problems triggered by sounds or smells, a team led by scientists at the University of Cambridge, UK, and Baylor College of Medicine, Houston, USA, discovered that the boys were missing a single gene, known as TRPC5, which sits on the X chromosome.

3 Jul 2024

Simple exercises can prevent nerve damage during cancer treatments

Cancer treatments often cause nerve damage that can lead to long-lasting symptoms. Medication has proven ineffective in these cases.

1 Jul 2024

Neanderthal child with Down syndrome reveals ancient caregiving practices

Research reveals that Neanderthals provided extensive caregiving, allowing a child with Down syndrome and congenital ear pathology to survive for at least six years, highlighting their complex social structures.

1 Jul 2024

Loss of salt, body fluid can stimulate kidney regeneration and repair in mice

A loss of salt and body fluid can stimulate kidney regeneration and repair in mice, according to a NIH-funded study led by USC Stem Cell scientist Janos Peti-Peterdi and published in The Journal of Clinical Investigation.

28 Jun 2024

Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder

When Michael Pirovolakis received an individualized gene therapy in a single-patient clinical trial at The Hospital for Sick Children (SickKids) in March 2022, the course of his condition was dramatically altered.

28 Jun 2024

Study shows prognostic value of tissue bridges in cervical spinal cord injury

The prognosis for recovery from a spinal cord injury (SCI) is of great importance for those directly affected and those around them.

28 Jun 2024

New study links COVID-19 to lasting neuropsychiatric issues, highlights vaccination benefits

COVID-19 survivors face significantly higher risks of developing neuropsychiatric conditions, but vaccination reduces these risks over time.

27 Jun 2024

Moderate physical activity may be linked to reduced risk of ALS later in life

Moderate levels of physical activity and fitness may be linked to a reduced risk of amyotrophic lateral sclerosis (ALS) later in life, according to a new study published in the June 26, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology.

26 Jun 2024

Comparative study on preventative SMA therapies shows mixed outcomes

In a first-of-its-kind study, researchers compared the efficacy of preventative therapy for spinal muscular atrophy (SMA) between two well-matched study groups, using either gene therapy (onasemnogene abeparvovec) alone or in combination with risdiplam (oral medication) or nusinersen (intrathecal injection) administered before apparent signs of disease emerged.

25 Jun 2024

Researchers characterize thalamic and cortical neurons that respond to stimulation of the ocular surface

Nerve fibers on the eye surface are involved in many relevant physiological processes, from detecting and transmitting external stimuli to maintaining the integrity of the cornea.

25 Jun 2024

MRI connectome predicts gray matter atrophy progression in early Parkinson's disease

The structural and functional organization of the brain as shown on MRI can predict the progression of brain atrophy in patients with early-stage, mild Parkinson's disease, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA).

25 Jun 2024

Nerve News and Research

Discovery of TRPC5 gene's role in obesity and postnatal depression offers hope for new treatments

Neuromuscular training reduces chemotherapy-induced neuropathy and improves patient outcomes

Innovative research sheds light on migraine mechanisms and potential therapies

New signaling pathway identified in aural migraine headaches

New insights into brain energy metabolism may lead to neurodegenerative disease therapies

Gene discovery points to oxytocin for depression

Simple exercises can prevent nerve damage during cancer treatments

Neanderthal child with Down syndrome reveals ancient caregiving practices

Loss of salt, body fluid can stimulate kidney regeneration and repair in mice

Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder

Study shows prognostic value of tissue bridges in cervical spinal cord injury

New study links COVID-19 to lasting neuropsychiatric issues, highlights vaccination benefits

Moderate physical activity may be linked to reduced risk of ALS later in life

Comparative study on preventative SMA therapies shows mixed outcomes

Researchers characterize thalamic and cortical neurons that respond to stimulation of the ocular surface

MRI connectome predicts gray matter atrophy progression in early Parkinson's disease

New MDMA variants could be promising alternatives for safe psychotherapeutic applications

Mouse studies suggest gestational CBD exposure alters offspring behavior and brain function

UCL research reveals anxiety as a major risk factor for Parkinson's

New ketamine slow-release tablet shows promise in treating severe depression

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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